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Independent prognostic value of HIF‑1α expression in radiofrequency ablation of lung cancer

  • Authors:
    • Jun Wan
    • Xiean Ling
    • Zhanpeng Rao
    • Bin Peng
    • Guanggui Ding
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, The Shenzhen People's Hospital, The Second Clinical Medicine College of Jinan University, Shenzhen, Guangdong 518020, P.R. China
    Copyright: © Wan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 849-857
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    Published online on: November 21, 2019
       https://doi.org/10.3892/ol.2019.11130
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Abstract

Radiofrequency ablation (RFA) is widely used in the treatment of lung cancer. Hypoxia‑inducible factor‑1α (HIF‑1α) is a crucial transcription factor regulating oxygen homeostasis that is involved in tumor cell metastasis. The present study investigated the impact of HIF‑1α expression and other factors, such as postoperative blood CD4+/CD8+ ratio, on the prognosis of patients with lung cancer who had received RFA treatment. A total of 80 patients with lung cancer were recruited between January 2011 and October 2016 at The Shenzhen People's Hospital. Lung cancer was confirmed following pathological or histological examination. All patients underwent RFA treatment. Patients were followed up for 6‑66 months. HIF‑1α expression in lung cancer tissues was assessed by immunohistochemistry. Multivariate survival analysis was performed using Cox proportional hazards model. The results demonstrated that HIF‑1α level was low in 36 patients and overexpressed in 44 patients with lung cancer. Kaplan‑Meier (KM) curve analysis demonstrated that the overall survival time of patients with high HIF‑1α expression was significantly shorter compared with patients with low HIF‑1α expression (P<0.05). Furthermore, the results from the KM model and log‑rank test revealed that age, Union for International Cancer Control stage, primary or metastatic cancer, chemotherapy, postoperative blood CD4+/CD8+ ratio, Eastern Cooperative Oncology Group performance status and HIF‑1α expression had significant effects on overall survival of patients with lung cancer. The results from Cox analysis demonstrated that high HIF‑1α expression, advanced age, clinical staging and chemotherapy were independent risk factors for the prognosis of lung cancer following RFA treatment, and that high HIF‑1α expression was associated with the increased risk (5.91‑fold) of mortality. In conclusion, the present study demonstrated that HIF‑1α expression was increased in lung cancer tissues and was associated with the prognosis of patients with lung cancer who were treated with RFA. These findings suggest that HIF‑1α expression may be considered as a marker for evaluating the prognosis of these patients.
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Copy and paste a formatted citation
Spandidos Publications style
Wan J, Ling X, Rao Z, Peng B and Ding G: Independent prognostic value of HIF‑1α expression in radiofrequency ablation of lung cancer. Oncol Lett 19: 849-857, 2020.
APA
Wan, J., Ling, X., Rao, Z., Peng, B., & Ding, G. (2020). Independent prognostic value of HIF‑1α expression in radiofrequency ablation of lung cancer. Oncology Letters, 19, 849-857. https://doi.org/10.3892/ol.2019.11130
MLA
Wan, J., Ling, X., Rao, Z., Peng, B., Ding, G."Independent prognostic value of HIF‑1α expression in radiofrequency ablation of lung cancer". Oncology Letters 19.1 (2020): 849-857.
Chicago
Wan, J., Ling, X., Rao, Z., Peng, B., Ding, G."Independent prognostic value of HIF‑1α expression in radiofrequency ablation of lung cancer". Oncology Letters 19, no. 1 (2020): 849-857. https://doi.org/10.3892/ol.2019.11130
Copy and paste a formatted citation
x
Spandidos Publications style
Wan J, Ling X, Rao Z, Peng B and Ding G: Independent prognostic value of HIF‑1α expression in radiofrequency ablation of lung cancer. Oncol Lett 19: 849-857, 2020.
APA
Wan, J., Ling, X., Rao, Z., Peng, B., & Ding, G. (2020). Independent prognostic value of HIF‑1α expression in radiofrequency ablation of lung cancer. Oncology Letters, 19, 849-857. https://doi.org/10.3892/ol.2019.11130
MLA
Wan, J., Ling, X., Rao, Z., Peng, B., Ding, G."Independent prognostic value of HIF‑1α expression in radiofrequency ablation of lung cancer". Oncology Letters 19.1 (2020): 849-857.
Chicago
Wan, J., Ling, X., Rao, Z., Peng, B., Ding, G."Independent prognostic value of HIF‑1α expression in radiofrequency ablation of lung cancer". Oncology Letters 19, no. 1 (2020): 849-857. https://doi.org/10.3892/ol.2019.11130
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