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Review

Genome‑wide analysis reveals the emerging roles of long non‑coding RNAs in cancer (Review)

  • Authors:
    • Xiaoxia Ren
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    Affiliations: Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming, Yunnan 650500, P.R. China
  • Pages: 588-594
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    Published online on: November 22, 2019
       https://doi.org/10.3892/ol.2019.11141
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Abstract

Cancer is the most intractable human disease that is primarily caused by genetic alterations. Recently, the general application of microarrays and high‑throughput sequencing technology has revealed various important roles of long noncoding RNAs (lncRNAs) in cancer. This review summarizes the function, mechanism, diagnostic and treatment potential of lncRNAs identified through genome‑wide analysis in cancer. Cell‑, tissue‑ and development stage‑specific expression patterns are major characteristics of cancer‑associated lncRNAs, and various genetic alterations are also implicated. Microarray and sequencing analyses serve important roles in mechanistic studies of either nuclear or cytoplasmic lncRNAs. Collectively, genome‑wide analysis is the inexorable trend of future studies or clinical applications of lncRNAs and offers a novel perspective regarding the prognosis and treatment of cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Ren X: Genome‑wide analysis reveals the emerging roles of long non‑coding RNAs in cancer (Review). Oncol Lett 19: 588-594, 2020.
APA
Ren, X. (2020). Genome‑wide analysis reveals the emerging roles of long non‑coding RNAs in cancer (Review). Oncology Letters, 19, 588-594. https://doi.org/10.3892/ol.2019.11141
MLA
Ren, X."Genome‑wide analysis reveals the emerging roles of long non‑coding RNAs in cancer (Review)". Oncology Letters 19.1 (2020): 588-594.
Chicago
Ren, X."Genome‑wide analysis reveals the emerging roles of long non‑coding RNAs in cancer (Review)". Oncology Letters 19, no. 1 (2020): 588-594. https://doi.org/10.3892/ol.2019.11141
Copy and paste a formatted citation
x
Spandidos Publications style
Ren X: Genome‑wide analysis reveals the emerging roles of long non‑coding RNAs in cancer (Review). Oncol Lett 19: 588-594, 2020.
APA
Ren, X. (2020). Genome‑wide analysis reveals the emerging roles of long non‑coding RNAs in cancer (Review). Oncology Letters, 19, 588-594. https://doi.org/10.3892/ol.2019.11141
MLA
Ren, X."Genome‑wide analysis reveals the emerging roles of long non‑coding RNAs in cancer (Review)". Oncology Letters 19.1 (2020): 588-594.
Chicago
Ren, X."Genome‑wide analysis reveals the emerging roles of long non‑coding RNAs in cancer (Review)". Oncology Letters 19, no. 1 (2020): 588-594. https://doi.org/10.3892/ol.2019.11141
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