circ‑FNTA accelerates proliferation and invasion of bladder cancer

Tian,Jianhai; Fan,Jiqiang; Xu,Jianping; Ren,Tong; Guo,Huaiyuan; Zhou,Lulian

doi:10.3892/ol.2019.11150

circ‑FNTA accelerates proliferation and invasion of bladder cancer

Authors:
- Jianhai Tian
- Jiqiang Fan
- Jianping Xu
- Tong Ren
- Huaiyuan Guo
- Lulian Zhou
View Affiliations

Affiliations: Department of Urology Surgery, Linyi Cancer Hospital, Linyi, Shandong 276000, P.R. China, Department of Emergency Surgery, The First People's Hospital of Tancheng, Linyi, Shandong 276199, P.R. China, Department of Head and Neck Thoracic Surgery, Linyi Cancer Hospital, Linyi, Shandong 276000, P.R. China
Published online on: November 27, 2019 https://doi.org/10.3892/ol.2019.11150
Pages: 1017-1023
Copyright: © Tian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Role of circ‑FNTA in the progression of bladder cancer (BCa) and its underlying mechanism were investigated. circ‑FNTA level in BCa tissues and cell lines was detected. The prognostic potential of circ‑FNTA was assessed by Kaplan‑Meier methods and the proliferative and invasive abilities of BCa influenced by circ‑FNTA were explored. Through dual‑luciferase reporter gene assay, miRNA‑451a, the target of circ‑FNTA and the target gene of miRNA‑451a, S1PR3 were determined. circ‑FNTA was upregulated in BCa, especially in invasive BCa. High level of circ‑FNTA indicated worse prognosis in BCa patients. Silence of circ‑FNTA attenuated the proliferative and invasive abilities of T24 and UM‑UC‑3 cells. miRNA‑451a was verified to be the target of circ‑FNTA, which was downregulated in BCa cells. circ‑FNTA negatively regulated the expression level of miRNA‑451a. Moreover, S1PR3 was the downstream gene of miRNA‑451a. Overexpression of miRNA‑451a downregulated S1PR3 level in BCa cells. circ‑FNTA accelerates the proliferative and invasive abilities of BCa through targeting miRNA‑451a/S1PR3 axis, and indicates a poor prognosis of BCa patients.

View Figures

View References

1	Siegel RL, Miller KD, Fedewa SA, Ahnen DJ, Meester RGS, Barzi A and Jemal A: Colorectal cancer statistics, 2017. CA Cancer J Clin. 67:177–193. 2017. View Article : Google Scholar : PubMed/NCBI
2	Soerjomataram I, Lortet-Tieulent J, Parkin DM, Ferlay J, Mathers C, Forman D and Bray F: Global burden of cancer in 2008: A systematic analysis of disability-adjusted life-years in 12 world regions. Lancet. 380:1840–1850. 2012. View Article : Google Scholar : PubMed/NCBI
3	Chen D, Li SG, Chen JY and Xiao M: miR-183 maintains canonical Wnt signaling activity and regulates growth and apoptosis in bladder cancer via targeting AXIN2. Eur Rev Med Pharmacol Sci. 22:4828–4836. 2018.PubMed/NCBI
4	Stone L: Bladder cancer: Mastering the immune microenvironment. Nat Rev Urol. 14:6392017. View Article : Google Scholar : PubMed/NCBI
5	Sargos P, Baumann BC, Eapen L, Christodouleas J, Bahl A, Murthy V, Efstathiou J, Fonteyne V, Ballas L, Zaghloul M, et al: Risk factors for loco-regional recurrence after radical cystectomy of muscle-invasive bladder cancer: A systematic-review and framework for adjuvant radiotherapy. Cancer Treat Rev. 70:88–97. 2018. View Article : Google Scholar : PubMed/NCBI
6	Grossman HB: Bladder cancer: Neoadjuvant is new again. Lancet Oncol. 12:830–831. 2011. View Article : Google Scholar : PubMed/NCBI
7	Morales-Barrera R, Suárez C, de Castro AM, Racca F, Valverde C, Maldonado X, Bastaros JM, Morote J and Carles J: Targeting fibroblast growth factor receptors and immune checkpoint inhibitors for the treatment of advanced bladder cancer: New direction and New Hope. Cancer Treat Rev. 50:208–216. 2016. View Article : Google Scholar : PubMed/NCBI
8	Liu X, Abraham JM, Cheng Y, Wang Z, Wang Z, Zhang G, Ashktorab H, Smoot DT, Cole RN, Boronina TN, et al: Synthetic circular RNA functions as a miR-21 sponge to suppress gastric carcinoma cell proliferation. Mol Ther Nucleic Acids. 13:312–321. 2018. View Article : Google Scholar : PubMed/NCBI
9	Hansen TB, Kjems J and Damgaard CK: Circular RNA and miR-7 in cancer. Cancer Res. 73:5609–5612. 2013. View Article : Google Scholar : PubMed/NCBI
10	Liu J, Liu T, Wang X and He A: Circles reshaping the RNA world: From waste to treasure. Mol Cancer. 16:582017. View Article : Google Scholar : PubMed/NCBI
11	Lasda E and Parker R: Circular RNAs: Diversity of form and function. RNA. 20:1829–1842. 2014. View Article : Google Scholar : PubMed/NCBI
12	Liu Y, Feng J, Sun M, Yang G, Yuan H, Wang Y, Bu Y, Zhao M, Zhang S and Zhang X: Long non-coding RNA HULC activates HBV by modulating HBx/STAT3/miR-539/APOBEC3B signaling in HBV-related hepatocellular carcinoma. Cancer Lett. 454:158–170. 2019. View Article : Google Scholar : PubMed/NCBI
13	Zhang B, Chen M, Jiang N, Shi K and Qian R: A regulatory circuit of circ-MTO1/miR-17/QKI-5 inhibits the proliferation of lung adenocarcinoma. Cancer Biol Ther. 20:1127–1135. 2019. View Article : Google Scholar : PubMed/NCBI
14	He J, Chen J, Ma B, Jiang L and Zhao G: CircLMTK2 acts as a novel tumor suppressor in gastric cancer. Biosci Rep. 39:392019. View Article : Google Scholar
15	Zhong Z, Lv M and Chen J: Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma. Sci Rep. 6:309192016. View Article : Google Scholar : PubMed/NCBI
16	Glažar P, Papavasileiou P and Rajewsky N: circBase: A database for circular RNAs. RNA. 20:1666–1670. 2014. View Article : Google Scholar : PubMed/NCBI
17	Sebti SM and Adjei AA: Farnesyltransferase inhibitors. Semin Oncol. 31 (Suppl 1):28–39. 2004. View Article : Google Scholar : PubMed/NCBI
18	Li JH, Liu S, Zhou H, Qu LH and Yang JH: starBase v2.0: Decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res. 42D:D92–D97. 2014. View Article : Google Scholar
19	Agarwal V, Bell GW, Nam JW and Bartel DP: Predicting effective microRNA target sites in mammalian mRNAs. eLife. 4:42015. View Article : Google Scholar
20	Matsushita R, Seki N, Chiyomaru T, Inoguchi S, Ishihara T, Goto Y, Nishikawa R, Mataki H, Tatarano S, Itesako T, et al: Tumour-suppressive microRNA-144-5p directly targets CCNE1/2 as potential prognostic markers in bladder cancer. Br J Cancer. 113:282–289. 2015. View Article : Google Scholar : PubMed/NCBI
21	Go H, Kim PJ, Jeon YK, Cho YM, Kim K, Park BH and Ku JY: Sphingosine-1-phosphate receptor 1 (S1PR1) expression in non-muscle invasive urothelial carcinoma: Association with poor clinical outcome and potential therapeutic target. Eur J Cancer. 51:1937–1945. 2015. View Article : Google Scholar : PubMed/NCBI
22	Feng J, Chen K, Dong X, Xu X, Jin Y, Zhang X, Chen W, Han Y, Shao L, Gao Y, et al: Genome-wide identification of cancer-specific alternative splicing in circRNA. Mol Cancer. 18:352019. View Article : Google Scholar : PubMed/NCBI
23	Su H, Tao T, Yang Z, Kang X, Zhang X, Kang D, Wu S and Li C: Circular RNA cTFRC acts as the sponge of microRNA-107 to promote bladder carcinoma progression. Mol Cancer. 18:272019. View Article : Google Scholar : PubMed/NCBI
24	Gu C, Zhou N, Wang Z, Li G, Kou Y, Yu S, Feng Y, Chen L, Yang J and Tian F: circGprc5a promoted bladder oncogenesis and metastasis through Gprc5a-targeting Peptide. Mol Ther Nucleic Acids. 13:633–641. 2018. View Article : Google Scholar : PubMed/NCBI
25	Chen X, Chen RX, Wei WS, Li YH, Feng ZH, Tan L, Chen JW, Yuan GJ, Chen SL, Guo SJ, et al: PRMT5 circular RNA promotes metastasis of urothelial carcinoma of the bladder through sponging miR-30c to induce epithelial-mesenchymal transition. Clin Cancer Res. 24:6319–6330. 2018. View Article : Google Scholar : PubMed/NCBI
26	Dangle PP, Zaharieva B, Jia H and Pohar KS: Ras-MAPK pathway as a therapeutic target in cancer - emphasis on bladder cancer. Recent Patents Anticancer Drug Discov. 4:125–136. 2009. View Article : Google Scholar
27	Chin K, DeVries S, Fridlyand J, Spellman PT, Roydasgupta R, Kuo WL, Lapuk A, Neve RM, Qian Z, Ryder T, et al: Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell. 10:529–541. 2006. View Article : Google Scholar : PubMed/NCBI
28	Qi X, Lin Y, Chen J and Shen B: Decoding competing endogenous RNA networks for cancer biomarker discovery. Brief Bioinform. Jan 30–2019.(Epub ahead of print). doi.org/10.1093/bib/bbz006. View Article : Google Scholar
29	Zhao J, Liu J, Lee JF, Zhang W, Kandouz M, VanHecke GC, Chen S, Ahn YH, Lonardo F and Lee MJ: TGF-β/SMAD3 pathway stimulates sphingosine-1 phosphate receptor 3 expression: Implication of sphingosine-1 phosphate receptor 3 in lung adenocarcinoma progression. J Biol Chem. 291:27343–27353. 2016. View Article : Google Scholar : PubMed/NCBI
30	Hirata N, Yamada S, Shoda T, Kurihara M, Sekino Y and Kanda Y: Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation. Nat Commun. 5:48062014. View Article : Google Scholar : PubMed/NCBI