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Article Open Access

circ‑FNTA accelerates proliferation and invasion of bladder cancer

  • Authors:
    • Jianhai Tian
    • Jiqiang Fan
    • Jianping Xu
    • Tong Ren
    • Huaiyuan Guo
    • Lulian Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Urology Surgery, Linyi Cancer Hospital, Linyi, Shandong 276000, P.R. China, Department of Emergency Surgery, The First People's Hospital of Tancheng, Linyi, Shandong 276199, P.R. China, Department of Head and Neck Thoracic Surgery, Linyi Cancer Hospital, Linyi, Shandong 276000, P.R. China
    Copyright: © Tian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1017-1023
    |
    Published online on: November 27, 2019
       https://doi.org/10.3892/ol.2019.11150
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Abstract

Role of circ‑FNTA in the progression of bladder cancer (BCa) and its underlying mechanism were investigated. circ‑FNTA level in BCa tissues and cell lines was detected. The prognostic potential of circ‑FNTA was assessed by Kaplan‑Meier methods and the proliferative and invasive abilities of BCa influenced by circ‑FNTA were explored. Through dual‑luciferase reporter gene assay, miRNA‑451a, the target of circ‑FNTA and the target gene of miRNA‑451a, S1PR3 were determined. circ‑FNTA was upregulated in BCa, especially in invasive BCa. High level of circ‑FNTA indicated worse prognosis in BCa patients. Silence of circ‑FNTA attenuated the proliferative and invasive abilities of T24 and UM‑UC‑3 cells. miRNA‑451a was verified to be the target of circ‑FNTA, which was downregulated in BCa cells. circ‑FNTA negatively regulated the expression level of miRNA‑451a. Moreover, S1PR3 was the downstream gene of miRNA‑451a. Overexpression of miRNA‑451a downregulated S1PR3 level in BCa cells. circ‑FNTA accelerates the proliferative and invasive abilities of BCa through targeting miRNA‑451a/S1PR3 axis, and indicates a poor prognosis of BCa patients.
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Copy and paste a formatted citation
Spandidos Publications style
Tian J, Fan J, Xu J, Ren T, Guo H and Zhou L: circ‑FNTA accelerates proliferation and invasion of bladder cancer . Oncol Lett 19: 1017-1023, 2020.
APA
Tian, J., Fan, J., Xu, J., Ren, T., Guo, H., & Zhou, L. (2020). circ‑FNTA accelerates proliferation and invasion of bladder cancer . Oncology Letters, 19, 1017-1023. https://doi.org/10.3892/ol.2019.11150
MLA
Tian, J., Fan, J., Xu, J., Ren, T., Guo, H., Zhou, L."circ‑FNTA accelerates proliferation and invasion of bladder cancer ". Oncology Letters 19.1 (2020): 1017-1023.
Chicago
Tian, J., Fan, J., Xu, J., Ren, T., Guo, H., Zhou, L."circ‑FNTA accelerates proliferation and invasion of bladder cancer ". Oncology Letters 19, no. 1 (2020): 1017-1023. https://doi.org/10.3892/ol.2019.11150
Copy and paste a formatted citation
x
Spandidos Publications style
Tian J, Fan J, Xu J, Ren T, Guo H and Zhou L: circ‑FNTA accelerates proliferation and invasion of bladder cancer . Oncol Lett 19: 1017-1023, 2020.
APA
Tian, J., Fan, J., Xu, J., Ren, T., Guo, H., & Zhou, L. (2020). circ‑FNTA accelerates proliferation and invasion of bladder cancer . Oncology Letters, 19, 1017-1023. https://doi.org/10.3892/ol.2019.11150
MLA
Tian, J., Fan, J., Xu, J., Ren, T., Guo, H., Zhou, L."circ‑FNTA accelerates proliferation and invasion of bladder cancer ". Oncology Letters 19.1 (2020): 1017-1023.
Chicago
Tian, J., Fan, J., Xu, J., Ren, T., Guo, H., Zhou, L."circ‑FNTA accelerates proliferation and invasion of bladder cancer ". Oncology Letters 19, no. 1 (2020): 1017-1023. https://doi.org/10.3892/ol.2019.11150
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