Open Access

LINC00365‑SCGB2A1 axis inhibits the viability of breast cancer through targeting NF‑κB signaling

  • Authors:
    • Lichao Zhang
    • Xiaoyu Yan
    • Sihang Yu
    • Xinru Zhong
    • Rui Tian
    • Long Xu
    • Xuehai Bian
    • Jing Su
  • View Affiliations

  • Published online on: November 29, 2019     https://doi.org/10.3892/ol.2019.11166
  • Pages: 753-762
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Breast cancer is the most common high‑grade malignancy in women. The lack of therapeutic targets has limited the treatment of breast cancer. Recently, long noncoding RNAs (lncRNAs) have been demonstrated to be dysregulated in various types of cancer. However, the specific mechanisms by which lncRNAs influence breast cancer have remained largely unclear. To bridge this research gap, the present study focused on the lncRNA LINC00365, which is expressed at a low level in breast cancer. Secretoglobin family 2A member 1 (SCGB2A1) was identified as a potential target protein regulated by LINC00365. The results of the present study demonstrated that the overexpression of LINC00365 and SCGB2A1 inhibited cell viability and induced cell apoptosis through the inhibition of the NF‑κB signaling pathway in breast cancer cells. These findings indicated that LINC00365 may serve a crucial role in breast cancer and may be considered as a novel target for the clinical treatment of breast cancer.
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January-2020
Volume 19 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang L, Yan X, Yu S, Zhong X, Tian R, Xu L, Bian X and Su J: LINC00365‑SCGB2A1 axis inhibits the viability of breast cancer through targeting NF‑κB signaling. Oncol Lett 19: 753-762, 2020
APA
Zhang, L., Yan, X., Yu, S., Zhong, X., Tian, R., Xu, L. ... Su, J. (2020). LINC00365‑SCGB2A1 axis inhibits the viability of breast cancer through targeting NF‑κB signaling. Oncology Letters, 19, 753-762. https://doi.org/10.3892/ol.2019.11166
MLA
Zhang, L., Yan, X., Yu, S., Zhong, X., Tian, R., Xu, L., Bian, X., Su, J."LINC00365‑SCGB2A1 axis inhibits the viability of breast cancer through targeting NF‑κB signaling". Oncology Letters 19.1 (2020): 753-762.
Chicago
Zhang, L., Yan, X., Yu, S., Zhong, X., Tian, R., Xu, L., Bian, X., Su, J."LINC00365‑SCGB2A1 axis inhibits the viability of breast cancer through targeting NF‑κB signaling". Oncology Letters 19, no. 1 (2020): 753-762. https://doi.org/10.3892/ol.2019.11166