Open Access

Prognostic significance of peritumoral fibrosis after resection of pancreatic head cancer

  • Authors:
    • Peng Chen
    • Youmei Wang
    • Xiaosan Fang
    • Xiaoming Wang
    • Guannan Wang
  • View Affiliations

  • Published online on: December 4, 2019     https://doi.org/10.3892/ol.2019.11181
  • Pages: 1235-1240
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Prognostic value of peritumoral fibrosis (PF) in pancreatic head cancer after resection was evaluated. A total of 143 pancreatic cancer patients who underwent tumor resection were enrolled. All patients underwent routine preoperative examination, including contrast-enhanced computed tomography (CT) or magnetic resonance imaging (MRI). Patients receiving preoperative chemoradiation were excluded because it affects the proportion of fibrosis and cancer cells. Histopathological confirmation and classification of pancreatic head cancer (PHC) was made according to the standards of World Health Organization and the American Joint Committee on Cancer (AJCC). The presence of fibrosis was assessed histologically, and correlated with the clinicopathological characteristics and overall survival using univariate Kaplan‑Meier analysis and a stepwise multivariable Cox regression model. Vein resection, resection margin, grading, nodal status, preoperative CA19‑9 levels and PF were significantly associated with overall survival. Multivariate analysis showed that all the aforementioned were independent predictive factors of survival. In addition, the survival of patients with PF was significantly worse compared to those without (HR 1.392; P=0.027). Tumor necrosis is a valuable prognostic tool that can be included in the routine post‑resection histopathological evaluation of pancreatic head cancer patients.
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February-2020
Volume 19 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Chen P, Wang Y, Fang X, Wang X and Wang G: Prognostic significance of peritumoral fibrosis after resection of pancreatic head cancer. Oncol Lett 19: 1235-1240, 2020
APA
Chen, P., Wang, Y., Fang, X., Wang, X., & Wang, G. (2020). Prognostic significance of peritumoral fibrosis after resection of pancreatic head cancer. Oncology Letters, 19, 1235-1240. https://doi.org/10.3892/ol.2019.11181
MLA
Chen, P., Wang, Y., Fang, X., Wang, X., Wang, G."Prognostic significance of peritumoral fibrosis after resection of pancreatic head cancer". Oncology Letters 19.2 (2020): 1235-1240.
Chicago
Chen, P., Wang, Y., Fang, X., Wang, X., Wang, G."Prognostic significance of peritumoral fibrosis after resection of pancreatic head cancer". Oncology Letters 19, no. 2 (2020): 1235-1240. https://doi.org/10.3892/ol.2019.11181