Downregulation of long non‑coding RNA NR2F2‑AS1 inhibits proliferation and induces apoptosis of nasopharyngeal carcinoma cells by upregulating the expression of PTEN

Qin,He; Qin,Chong

doi:10.3892/ol.2019.11211

Downregulation of long non‑coding RNA NR2F2‑AS1 inhibits proliferation and induces apoptosis of nasopharyngeal carcinoma cells by upregulating the expression of PTEN

Authors:
- He Qin
- Chong Qin
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Affiliations: Department of Otolaryngology, Head and Neck Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Changping, Beijing 102218, P.R. China, Department of Emergency, Dongying Shengli Hospital, Dongying, Shandong 257055, P.R. China
Published online on: December 12, 2019 https://doi.org/10.3892/ol.2019.11211
Pages: 1145-1150
Copyright: © Qin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The novel long non‑coding RNA NR2F2‑AS1 has been characterized as an oncogene in lung cancer. The present study aimed to investigate the role of NR2F2‑AS1 in nasopharyngeal carcinoma (NPC). The results demonstrated that expression of NR2F2‑AS1 and phosphatase and tensin homolog (PTEN) were negatively associated with each other in NPC tissues. Furthermore, upregulated NR2F2‑AS1 expression levels and downregulated PTEN expression levels in NPC tissues predicted less favorable survival outcomes in patients with NPC. Transfection of NPC cells with NR2F2‑AS1 small interfering RNA resulted in increased expression of PTEN. In addition, NR2F2‑AS1 silencing and PTEN overexpression resulted in decreased proliferation and an increase in the apoptotic rate of NPC cells. In conclusion, NR2F2‑AS1 downregulation decreased proliferation and increased apoptosis of NPC cells via upregulation of PTEN.

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