Expression and clinical significance of WWOX, Elf5, Snail1 and EMT related factors in epithelial ovarian cancer

Hu,Yakun; Yan,Yuchen; Xu,Yang; Yang,He; Fang,Lisha; Liu,Yongli; Li,Xin; Li,Qiang; Yan,Hongchao

doi:10.3892/ol.2019.11213

February-2020 Volume 19 Issue 2

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February-2020 Volume 19 Issue 2

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Article Open Access

Expression and clinical significance of WWOX, Elf5, Snail1 and EMT related factors in epithelial ovarian cancer

Authors:
- Yakun Hu
- Yuchen Yan
- Yang Xu
- He Yang
- Lisha Fang
- Yongli Liu
- Xin Li
- Qiang Li
- Hongchao Yan
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Affiliations: Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China, Department of Clinical Medicine, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China, Department of Gynaecology and Obstetrics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China, Department of Gynaecology, Xuzhou No. 1 People's Hospital Affiliated to Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China, Department of Gynaecology, Xuzhou Maternal and Child Health Care Hospital Affiliated to Xuzhou Medical University, Xuzhou, Jiangsu 221009, P.R. China, Xuzhou Medical University Science Park Co. Ltd., Xuzhou, Jiangsu 221000, P.R. China

Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 1281-1290
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Published online on: December 12, 2019

https://doi.org/10.3892/ol.2019.11213
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Abstract

Expression and clinical significance of WW domain‑containing oxidoreductase (WWOX), Elf5, Snail1 and epithelial‑mesenchymal transition (EMT) related factors in epithelial ovarian cancer were investigated. Ovarian cancer tissues of 300 epithelial ovarian cancer patients and the adjacent normal tissues were analyzed. Immunohistochemical method was used to detect the expressions of WWOX, Elf5, Snail1 and EMT marker molecules in the specimens. The relationship between the indicators and clinicopathological parameters, and prognosis of patients with ovarian cancer was analyzed. The relationship between WWOX, Elf5, Snail1 and EMT marker molecules E‑cadherin, N‑cadherin and vimentin in ovarian cancer tissues was analyzed. The expression levels of WWOX, Elf5, Snail1 and EMT marker molecules in epithelial ovarian cancer tissues were significantly different from those in adjacent normal tissues, and were related to surgical pathological stage, pathological grade and lymph node metastasis. High expressions of WWOX and Elf5 were related to the survival rate of patients. The survival rate of patients with positive expression was significantly higher than that of negative expression. FIGO stage, pathological grade, lymph node metastasis and expression of WWOX and Elf5 were all independent factors affecting postoperative prognosis in ovarian cancer patients. In conclusion, the expression levels of WWOX, Elf5, Snail1 and EMT related factors in epithelial ovarian cancer tissues are consistent and different. The expression levels of WWOX and Elf5 are related to the survival and prognosis of patients with epithelial ovarian cancer.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Expression and clinical significance of WWOX, Elf5, Snail1 and EMT related factors in epithelial ovarian cancer

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Abstract

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