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Article Open Access

Long non‑coding RNA TTN‑AS1 promotes breast cancer cell migration and invasion via sponging miR‑140‑5p

Retraction in: /10.3892/ol.2020.12018
  • Authors:
    • Jie Xue
    • Zhixia Zhang
    • Xiaona Li
    • Qingfang Ren
    • Qinghua Wang
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, Linyi Cancer Hospital, Linyi, Shandong 276000, P.R. China, Department of Medical Oncology, Linyi Cancer Hospital, Linyi, Shandong 276000, P.R. China
    Copyright: © Xue et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1255-1260
    |
    Published online on: December 17, 2019
       https://doi.org/10.3892/ol.2019.11222
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Abstract

Breast cancer (BC) is one of the most common fatal cancers. Recent studies have identified the vital role of long non‑coding RNAs (lncRNAs) in the development and progression of BC. In this investigation, lncRNA TTN‑AS1 was studied to identify its function in the metastasis of BC. TTN‑AS1 expression of tissues was detected by real‑time quantitative polymerase chain reaction (RT‑qPCR) in 56 BC patients. Wound healing assay and transwell assay were used to observe the biological behavior changes of BC cells through gain or loss of TTN‑AS1. In addition, luciferase assays and RNA immunoprecipitation (RIP) assay were performed to discover the potential targets of TTN‑AS1 in BC cells. TTN‑AS1 expression level in BC samples was higher than that of adjacent tissue. Besides, the ability of cell migration and invasion of BC cells was inhibited after TTN‑AS1 was silenced, while cell migration and cell invasion of BC cells were promoted after TTN‑AS1 was overexpressed. In addition, miR‑140‑5p was upregulated after silencing of TTN‑AS1 in BC cells, while miR‑140‑5p was downregulated after overexpression of TTN‑AS1 in BC cells. Furthermore, luciferase assays and RIP assay showed that miR‑140‑5p was a direct target of TTN‑AS1 in BC. Our study uncovered a new oncogene in BC and suggests that TTN‑AS1 enhances BC cell migration and invasion via sponging miR‑140‑5p, which provides a novel therapeutic target for BC patients.
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Copy and paste a formatted citation
Spandidos Publications style
Xue J, Zhang Z, Li X, Ren Q and Wang Q: Long non‑coding RNA TTN‑AS1 promotes breast cancer cell migration and invasion via sponging miR‑140‑5p Retraction in /10.3892/ol.2020.12018. Oncol Lett 19: 1255-1260, 2020.
APA
Xue, J., Zhang, Z., Li, X., Ren, Q., & Wang, Q. (2020). Long non‑coding RNA TTN‑AS1 promotes breast cancer cell migration and invasion via sponging miR‑140‑5p Retraction in /10.3892/ol.2020.12018. Oncology Letters, 19, 1255-1260. https://doi.org/10.3892/ol.2019.11222
MLA
Xue, J., Zhang, Z., Li, X., Ren, Q., Wang, Q."Long non‑coding RNA TTN‑AS1 promotes breast cancer cell migration and invasion via sponging miR‑140‑5p Retraction in /10.3892/ol.2020.12018". Oncology Letters 19.2 (2020): 1255-1260.
Chicago
Xue, J., Zhang, Z., Li, X., Ren, Q., Wang, Q."Long non‑coding RNA TTN‑AS1 promotes breast cancer cell migration and invasion via sponging miR‑140‑5p Retraction in /10.3892/ol.2020.12018". Oncology Letters 19, no. 2 (2020): 1255-1260. https://doi.org/10.3892/ol.2019.11222
Copy and paste a formatted citation
x
Spandidos Publications style
Xue J, Zhang Z, Li X, Ren Q and Wang Q: Long non‑coding RNA TTN‑AS1 promotes breast cancer cell migration and invasion via sponging miR‑140‑5p Retraction in /10.3892/ol.2020.12018. Oncol Lett 19: 1255-1260, 2020.
APA
Xue, J., Zhang, Z., Li, X., Ren, Q., & Wang, Q. (2020). Long non‑coding RNA TTN‑AS1 promotes breast cancer cell migration and invasion via sponging miR‑140‑5p Retraction in /10.3892/ol.2020.12018. Oncology Letters, 19, 1255-1260. https://doi.org/10.3892/ol.2019.11222
MLA
Xue, J., Zhang, Z., Li, X., Ren, Q., Wang, Q."Long non‑coding RNA TTN‑AS1 promotes breast cancer cell migration and invasion via sponging miR‑140‑5p Retraction in /10.3892/ol.2020.12018". Oncology Letters 19.2 (2020): 1255-1260.
Chicago
Xue, J., Zhang, Z., Li, X., Ren, Q., Wang, Q."Long non‑coding RNA TTN‑AS1 promotes breast cancer cell migration and invasion via sponging miR‑140‑5p Retraction in /10.3892/ol.2020.12018". Oncology Letters 19, no. 2 (2020): 1255-1260. https://doi.org/10.3892/ol.2019.11222
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