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Article

Inhibition of acetylcholinesterase activity and β‑amyloid oligomer formation by 6‑bromotryptamine A, a multi‑target anti‑Alzheimer's molecule

  • Authors:
    • Xiaofeng Jin
    • Minjun Wang
    • Jieyi Shentu
    • Chunhui Huang
    • Yujing Bai
    • Hanbo Pan
    • Difan Zhang
    • Zhijun Yuan
    • Hui Zhang
    • Xiao Xiao
    • Xiang Wu
    • Lijian Ding
    • Qinwen Wang
    • Shan He
    • Wei Cui
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, Zhejiang 315211, P.R. China, Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, Zhejiang 315211, P.R. China, Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, Ningbo, Zhejiang 315211, P.R. China
  • Pages: 1593-1601
    |
    Published online on: December 18, 2019
       https://doi.org/10.3892/ol.2019.11226
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Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by learning and memory impairments. Recent studies have suggested that AD can be induced by multiple factors, such as cholinergic system dysfunction and β‑amyloid (Aβ) neurotoxicity. It was reported that 6‑bromo‑N‑propionyltryptamine could treat neurological diseases, including AD. In the present study, 6‑bromotryptamine A, a derivative of 6‑bromo‑N‑propionyltryptamine, was synthesized by the condensation of 2‑(6‑bromo‑1H‑indol‑3‑yl)ethan‑1‑amine and 2‑(4‑bromophenyl)acetic acid, and was used as a potential anti‑AD molecule. Furthermore, scopolamine can induce impairments of learning and memory, and was widely used to establish AD animal models. The results demonstrated that 6‑bromotryptamine A significantly prevented scopolamine‑induced short‑term cognitive impairments, as revealed by various behavioral tests in mice. Furthermore, an acetylcholinesterase (AChE) activity assay revealed that 6‑bromotryptamine A directly inhibited AChE activity. Notably, it was observed that 6‑bromotryptamine A blocked the formation of Aβ oligomer, as evaluated by the dot blot assay. All these results suggested that 6‑bromotryptamine A may be used to prevent impairments in short‑term learning and memory ability possibly via the inhibition of AChE and the blockade of Aβ oligomer formation.
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View References

1 

Luo W, Wang T, Hong C, Yang YC, Chen Y, Cen J, Xie SQ and Wang CJ: Design, synthesis and evaluation of 4-dimethylamine flavonoid derivatives as potential multifunctional anti-Alzheimer agents. Eur J Med Chem. 122:17–26. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Bhounsule AS, Bhatt LK, Prabhavalkar KS and Oza M: Cyclin dependent kinase 5: A novel avenue for Alzheimer's disease. Brain Res Bull. 132:28–38. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Zhao XJ, Gong DM, Jiang YR, Guo D, Zhu Y and Deng YC: Multipotent AChE and BACE-1 inhibitors for the treatment of Alzheimer's disease: Design, synthesis and bio-analysis of 7-amino-1,4-dihydro-2H-isoquilin-3-one derivates. Eur J Med Chem. 138:738–747. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Cieslikiewicz-Bouet M, Chao S, Jean L, et al: Toward an innovative treatment of Alzheimer's disease: Synthesis and evaluation of multi-target directed ligands (MTDLs) targeting acetylcholinesterase (AChE) and alpha7 nicotinic acetylchloline receptors (alpha7 nAChRs). J Neurochem. 142:209–210. 2017.

5 

Barnett R: Alzheimer's disease. Lancet. 393:15892019. View Article : Google Scholar : PubMed/NCBI

6 

Saxena M and Dubey R: Target enzyme in Alzheimer's disease: Acetylcholinesterase inhibitors. Curr Top Med Chem. 19:264–275. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Huang L, Lin J, Xiang S, Zhao K, Yu J, Zheng J, Xu D, Mak S, Hu S, Nirasha S, et al: Sunitinib, a clinically used anticancer drug, is a potent AChE inhibitor and attenuates cognitive impairments in mice. Acs Chem Neurosci. 7:1047–1056. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Ghumatkar PJ, Patil SP, Jain PD, Tambe RM and Sathaye S: Nootropic, neuroprotective and neurotrophic effects of phloretin in scopolamine induced amnesia in mice. Pharmacol Biochem Behav. 135:182–191. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Sang ZP, Qiang XM, Li Y, Xu R, Cao Z, Song Q, Wang T, Zhang X, Liu H, Tan Z and Deng Y: Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease. Eur J Med Chem. 135:307–323. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Ding L, He S, Wu W, Jin H, Zhu P, Zhang J, Wang T, Yuan Y and Yan X: Discovery and structure-based optimization of 6-bromotryptamine derivatives as potential 5-HT2A receptor antagonists. Molecules. 20:17675–17683. 2015. View Article : Google Scholar : PubMed/NCBI

11 

He S, Ding L and Yan X: New 6-bromotryptamine derivatives from marine bacterium pseudoalteromonas rubra QD1-2 and the impact of side chain length on their cytotoxicity. Planta Med. 79:8452013. View Article : Google Scholar

12 

Chen HX, Xiang SY, Huang L, Lin J, Hu S, Mak SH, Wang C, Wang Q, Cui W and Han Y: Tacrine(10)-hupyridone, a dual-binding acetylcholinesterase inhibitor, potently attenuates scopolamine-induced impairments of cognition in mice. Metab Brain Dis. 33:1131–1139. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Bae HJ, Sowndhararajan K, Park HB, Kim SY, Kim S, Kim DH, Choi JW, Jang DS, Ryu JH and Park SJ: Danshensu attenuates scopolamine and amyloid-β-induced cognitive impairments through the activation of PKA-CREB signaling in mice. Neurochem Int. 131:1045372019. View Article : Google Scholar : PubMed/NCBI

14 

Kraeuter AK, Guest PC and Sarnyai Z: The open field test for measuring locomotor activity and anxiety-like behavior. Methods Mol Biol. 1916:99–103. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Overstreet DH: The open field test for two. J Psychopharmacol. 21:1402007. View Article : Google Scholar : PubMed/NCBI

16 

Lueptow LM: Novel object recognition test for the investigation of learning and memory in mice. J Vis Exp; 2017, View Article : Google Scholar

17 

Chen L, Huang C, Shentu J, Wang M, Yan S, Zhou F, Zhang Z, Wang C, Han Y, Wang Q and Cui W: Indirubin derivative 7-bromoindirubin-3-oxime (7Bio) attenuates Aβ oligomer-induced cognitive impairments in mice. Front Mol Neurosci. 10:3932017. View Article : Google Scholar : PubMed/NCBI

18 

D'Hooge R and De Deyn PP: Applications of the Morris water maze in the study of learning and memory. Brain Res Brain Res Rev. 36:60–90. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Chen H, Wu X, Gu X, Zhou Y, Ye L, Zhang K, Pan H, Wang J, Wei H, Zhu B, et al: Tacrine(10)-hupyridone prevents post-operative cognitive dysfunction via the activation of BDNF pathway and the inhibition of AChE in aged mice. Front Cell Neurosci. 12:3962018. View Article : Google Scholar : PubMed/NCBI

20 

Santos WP, da Silva Carvalho AC, dos Santos Estevam C, Santana AE and Marçal RM: In vitro and ex vivo anticholinesterase activities of Erythrina velutina leaf extracts. Pharm Biol. 50:919–924. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Li FJ, Liu Y, Yuan Y, Yang B, Liu ZM and Huang LQ: Molecular interaction studies of acetylcholinesterase with potential acetylcholinesterase inhibitors from the root of Rhodiola crenulata using molecular docking and isothermal titration calorimetry methods. Int J Biol Macromol. 104:527–532. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Jain AN: Surflex-Dock 2.1: Robust performance from ligand energetic modeling, ring flexibility, and knowledge-based search. J Comput Aided Mol Des. 21:281–306. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Xiang S, Liu F, Lin J, Chen H, Huang C, Chen L, Zhou Y, Ye L, Zhang K, Jin J, et al: Fucoxanthin inhibits β-amyloid assembly and attenuates β-amyloid oligomer-induced cognitive impairments. J Agric Food Chem. 65:4092–4102. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Chunhui H, Dilin X, Ke Z, Jieyi S, Sicheng Y, Dapeng W, Qinwen W and Wei C: A11-positive β-amyloid oligomer preparation and assessment using dot blotting analysis. J Vis Exp; 2018, View Article : Google Scholar

25 

Sun K, Bai Y, Zhao R, Guo Z, Su X, Li P and Yang P: Neuroprotective effects of matrine on scopolamine-induced amnesia via inhibition of AChE/BuChE and oxidative stress. Metab Brain Dis. 34:173–181. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Nakako T, Iwamura Y, Matsumoto A, Matsumoto K, Ikejiri M and Ikeda K: Effects of donepezil on scopolamine-induced cognitive impairment and Alzheimer's disease-like change in quantitative EEG analysis in rhesus monkeys. Eur Neuropsychopharm. 27:S736–S737. 2017. View Article : Google Scholar

27 

Li WM, Kan KK, Carlier PR, Pang YP and Han YF: East meets west in the search for Alzheimer's therapeutics-novel dimeric inhibitors from tacrine and huperzine a. Curr Alzheimer Res. 4:386–396. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Lazarevic-Pasti T, Leskovac A, Momic T, Petrovic S and Vasic V: Modulators of acetylcholinesterase activity: From Alzheimer's disease to anti-cancer drugs. Curr Med Chem. 24:3283–3309. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Xi HJ, Wu RP, Liu JJ, Zhang LJ and Li ZS: Role of acetylcholinesterase in lung cancer. Thorac Cancer. 6:390–398. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Ruiz-Espejo F, Cabezas-Herrera J, Illana J, Campoy FJ, Muñoz-Delgado E and Vidal CJ: Breast cancer metastasis alters acetylcholinesterase activity and the composition of enzyme forms in axillary lymph nodes. Breast Cancer Res Tr. 80:105–114. 2003. View Article : Google Scholar

31 

Ki YS, Park EY, Lee HW, Oh MS, Cho YW, Kwon YK, Moon JH and Lee KT: Donepezil, a potent acetylcholinesterase inhibitor, induces caspase-dependent apoptosis in human promyelocytic leukemia HL-60 cells. Biol Pharm Bull. 33:1054–1059. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Hyatt JL, Tsurkan L, Morton CL, Yoon KJ, Harel M, Brumshtein B, Silman I, Sussman JL, Wadkins RM and Potter PM: Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11. Chem-Biol Interact. 157-158:247–252. 2005. View Article : Google Scholar : PubMed/NCBI

33 

al-Jafari AA, Duhaiman AS and Kamal MA: Inhibition of human acetylcholinesterase by cyclophosphamide. Toxicology. 96:1–6. 1995. View Article : Google Scholar : PubMed/NCBI

34 

Cheng S, Zheng W, Gong P, Zhou Q, Xie Q, Yu L, Zhang P, Chen L, Li J, Chen J, et al: (−)-Meptazinol-melatonin hybrids as novel dual inhibitors of cholinesterases and amyloid-β aggregation with high antioxidant potency for Alzheimer's therapy. Bioorg Med Chem. 23:3110–3118. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Liu FF, Dong XY, He LZ, Middelberg APJ and Sun Y: Molecular insight into conformational transition of amyloid β-peptide 42 inhibited by (−)-epigallocatechin-3-gallate probed by molecular simulations. J Phys Chem B. 115:11879–11887. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Du WJ, Guo JJ, Gao MT, Hu SQ, Dong XY, Han YF, Liu FF, Jiang S and Sun Y: Brazilin inhibits amyloid β-protein fibrillogenesis, remodels amyloid fibrils and reduces amyloid cytotoxicity. Sci Rep. 5:79922015. View Article : Google Scholar : PubMed/NCBI

37 

Aykac A, Ozbeyli D, Uncu M, Ertaş B, Kılınc O, Şen A, Orun O and Sener G: Evaluation of the protective effect of Myrtus communis in scopolamine-induced Alzheimer model through cholinergic receptors. Gene. 689:194–201. 2019. View Article : Google Scholar : PubMed/NCBI

38 

Bird TD: Genetic aspects of Alzheimer disease. Genet Med. 10:231–239. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Wang T, Liu XH, Guan J, Ge S, Wu MB, Lin JP and Yang LR: Advancement of multi-target drug discoveries and promising applications in the field of Alzheimer's disease. Eur J Med Chem. 169:200–223. 2019. View Article : Google Scholar : PubMed/NCBI

40 

Jagust W: Imaging the evolution and pathophysiology of Alzheimer disease. Nat Rev Neurosci. 19:687–700. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Scheltens P, Blennow K, Breteler MM, de Strooper B, Frisoni GB, Salloway S and Van der Flier WM: Alzheimer's disease. Lancet. 388:505–517. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jin X, Wang M, Shentu J, Huang C, Bai Y, Pan H, Zhang D, Yuan Z, Zhang H, Xiao X, Xiao X, et al: Inhibition of acetylcholinesterase activity and β‑amyloid oligomer formation by 6‑bromotryptamine A, a multi‑target anti‑Alzheimer's molecule. Oncol Lett 19: 1593-1601, 2020.
APA
Jin, X., Wang, M., Shentu, J., Huang, C., Bai, Y., Pan, H. ... Cui, W. (2020). Inhibition of acetylcholinesterase activity and β‑amyloid oligomer formation by 6‑bromotryptamine A, a multi‑target anti‑Alzheimer's molecule. Oncology Letters, 19, 1593-1601. https://doi.org/10.3892/ol.2019.11226
MLA
Jin, X., Wang, M., Shentu, J., Huang, C., Bai, Y., Pan, H., Zhang, D., Yuan, Z., Zhang, H., Xiao, X., Wu, X., Ding, L., Wang, Q., He, S., Cui, W."Inhibition of acetylcholinesterase activity and β‑amyloid oligomer formation by 6‑bromotryptamine A, a multi‑target anti‑Alzheimer's molecule". Oncology Letters 19.2 (2020): 1593-1601.
Chicago
Jin, X., Wang, M., Shentu, J., Huang, C., Bai, Y., Pan, H., Zhang, D., Yuan, Z., Zhang, H., Xiao, X., Wu, X., Ding, L., Wang, Q., He, S., Cui, W."Inhibition of acetylcholinesterase activity and β‑amyloid oligomer formation by 6‑bromotryptamine A, a multi‑target anti‑Alzheimer's molecule". Oncology Letters 19, no. 2 (2020): 1593-1601. https://doi.org/10.3892/ol.2019.11226
Copy and paste a formatted citation
x
Spandidos Publications style
Jin X, Wang M, Shentu J, Huang C, Bai Y, Pan H, Zhang D, Yuan Z, Zhang H, Xiao X, Xiao X, et al: Inhibition of acetylcholinesterase activity and β‑amyloid oligomer formation by 6‑bromotryptamine A, a multi‑target anti‑Alzheimer's molecule. Oncol Lett 19: 1593-1601, 2020.
APA
Jin, X., Wang, M., Shentu, J., Huang, C., Bai, Y., Pan, H. ... Cui, W. (2020). Inhibition of acetylcholinesterase activity and β‑amyloid oligomer formation by 6‑bromotryptamine A, a multi‑target anti‑Alzheimer's molecule. Oncology Letters, 19, 1593-1601. https://doi.org/10.3892/ol.2019.11226
MLA
Jin, X., Wang, M., Shentu, J., Huang, C., Bai, Y., Pan, H., Zhang, D., Yuan, Z., Zhang, H., Xiao, X., Wu, X., Ding, L., Wang, Q., He, S., Cui, W."Inhibition of acetylcholinesterase activity and β‑amyloid oligomer formation by 6‑bromotryptamine A, a multi‑target anti‑Alzheimer's molecule". Oncology Letters 19.2 (2020): 1593-1601.
Chicago
Jin, X., Wang, M., Shentu, J., Huang, C., Bai, Y., Pan, H., Zhang, D., Yuan, Z., Zhang, H., Xiao, X., Wu, X., Ding, L., Wang, Q., He, S., Cui, W."Inhibition of acetylcholinesterase activity and β‑amyloid oligomer formation by 6‑bromotryptamine A, a multi‑target anti‑Alzheimer's molecule". Oncology Letters 19, no. 2 (2020): 1593-1601. https://doi.org/10.3892/ol.2019.11226
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