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Role of Gd2O3‑doped carbon‑11‑choline‑lenvatinib nanoparticles contrast agent PET/CT in the diagnosis of patients with lung cancer

  • Authors:
    • Tong Zhou
    • Dongfang Hang
    • Ying Li
    • Jin Zhang
    • Huayang Wu
    • Hongyan Wang
    • Enbing Tian
    • Jun Yan
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine, Beijing 100700, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1117-1124
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    Published online on: December 23, 2019
       https://doi.org/10.3892/ol.2019.11243
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Abstract

Positron emission tomography‑computed tomography (PET/CT) is an efficient method for the diagnosis of various types of human cancer. Studies have demonstrated that Gd2O3‑doped carbon‑11‑choline (GdCho) can be used as a contrast nanoparticle for PET/CT in the diagnosis of patients with lung cancer. The aim of the present study was to evaluate the effect of GdCho‑lenvatinib nanoparticles contrast‑PET/CT (GdCho‑Len‑PET) in the diagnosis and treatment planning of a cohort of patients suspected of having lung cancer. The results of the present study demonstrated that GdCho‑Len could be used as an efficient PET/CT contrast agent for the diagnosis of patients with lung cancer. GdCho‑Len nanoparticles contrast agent exhibited a significantly improved longitudinal relaxivity compared with GdCho. The outcomes of the present study were that GdCho‑Len‑PET diagnosed 152 patients with lung cancer, whereas GdCho‑PET diagnosed 130 patients with lung cancer among the 172 patients. GdCho‑Len‑PET presented with higher accuracy and sensitivity compared with GdCho‑PET in diagnosing patients with lung cancer. All patients were further confirmed via histological analysis. GdCho‑Len‑PET contributed to the anticancer treatments in 56 out of 62 (90.3%) patients with lung cancer who were candidates for radiation therapy, 52 out of 57 (91.2%) patients with lung cancer undergoing adjuvant radiotherapy, and 13 out of 17 (76.5%) patients with lung cancer undergoing comprehensive therapy. Patients diagnosed using GdCho‑Len‑PET improved the survival of patients with lung cancer during a 420‑day follow up. In conclusion, GdCho‑Len‑PET increased the diagnostic efficacy and had a significant effect on survival for patients with lung cancer, and may therefore serve as a reliable method for human cancer diagnosis.
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1 

Ridge CA and Boiselle PM: Optimizing the lung cancer screening interval: The world is waiting. J Thorac Dis. 8:E1369–E1370. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Xing P, Wang S, Hao X, Zhang T and Li J: Clinical data from the real world: Efficacy of Crizotinib in Chinese patients with advanced ALK-rearranged non-small cell lung cancer and brain metastases. Oncotarget. 7:84666–84674. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Gao L, Xie S, Liu H, Liu P, Xiong Y, Da J, Que C, Dai H and Wang C: Lung cancer in patients with combined pulmonary fibrosis and emphysema revisited with the 2015 World Health Organization classification of lung tumors. Clin Respir J. 12:652–658. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Zhukovsky M, Varaksin A and Pakholkina O: Statistical analysis of observational study of the influence of radon and other risk factors on lung cancer incidence. Radiat Prot Dosimetry. 160:108–111. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global Cancer Statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Liu B, Yuan M, Sun Y, Cheng Z, Zhang Z, Hou S, Wang X and Liu J: Incidence and risk of hepatic toxicities associated with anaplastic lymphoma kinase inhibitors in the treatment of non-small-cell lung cancer: A systematic review and meta-analysis. Oncotarget. 9:9480–9488. 2017.PubMed/NCBI

8 

Leitinger M, Varosanec MV, Pikija S, Wass RE, Bandke D, Weis S, Studnicka M, Grinzinger S, McCoy MR, Hauer L and Sellner J: Fatal necrotizing encephalopathy after treatment with nivolumab for squamous non-small cell lung cancer: Case report and review of the literature. Front Immunol. 9:1082018. View Article : Google Scholar : PubMed/NCBI

9 

Yang JC, Mok T, Han B, Orlando M, Puri T and Park K: A review of regimens combining pemetrexed with an epidermal growth factor receptor tyrosine kinase inhibitor in the treatment of advanced nonsquamous non-small-cell lung cancer. Clin Lung Cancer. 19:27–34. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Takamori S, Toyokawa G, Takada K, Shoji F, Okamoto T and Maehara Y: Combination therapy of radiotherapy and Anti-PD-1/PD-L1 treatment in non-small-cell lung cancer: A Mini-review. Clin Lung Cancer. 19:12–16. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Bamji-Stocke S, van Berkel V, Miller DM and Frieboes HB: A review of metabolism-associated biomarkers in lung cancer diagnosis and treatment. Metabolomics. 14:812018. View Article : Google Scholar : PubMed/NCBI

12 

Vergnenègre A and Chouaïd C: Review of economic analyses of treatment for non-small-cell lung cancer (NSCLC). Expert Rev Pharmacoecon Outcomes Res. 18:519–528. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Yang X, Li M, Yang X, Zhao M, Huang Y, Dai X, Jiang T, Feng M, Zhan C and Wang Q: Uniport versus multiport video-assisted thoracoscopic surgery in the perioperative treatment of patients with T1-3N0M0 non-small cell lung cancer: A systematic review and meta-analysis. J Thorac Dis. 10:2186–2195. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Suzuki H, Hyodo I and Hasegawa Y: Prediction of decannulation, oral intake recovery, overall survival and lung metastasis following oral malignant tumor resection and reconstruction. Oncol Lett. 15:2686–2694. 2018.PubMed/NCBI

15 

Deng Y, Yang Y, Yao B, Ma L, Wu Q, Yang Z, Zhang L and Liu B: Paracrine signaling by VEGF-C promotes non-small cell lung cancer cell metastasis via recruitment of tumor-associated macrophages. Exp Cell Res. 364:208–216. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Song W, Kuang J, Li CX, Zhang M, Zheng D, Zeng X, Liu C and Zhang XZ: Enhanced immunotherapy based on photodynamic therapy for both primary and lung metastasis tumor eradication. ACS Nano. 12:1978–1989. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Du Q, Yu R, Wang H, Yan D, Yuan Q, Ma Y, Slamon D, Hou D, Wang H and Wang Q: Significance of tumor-associated autoantibodies in the early diagnosis of lung cancer. Clin Respir J. 12:2020–2028. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Cormio A, Cormio G, Musicco C, Sardanelli AM, Gasparre G and Gadaleta MN: Mitochondrial changes in endometrial carcinoma: Possible role in tumor diagnosis and prognosis (review). Oncol Rep. 33:1011–1018. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Cherkashin M, Aniskhin M, Berezina N and Puchkov D: CT and PET/CT fusion for lung cancer biopsy planning. BMJ Case Rep. 2017(pii): bcr-2017-221972. 2017.PubMed/NCBI

20 

Lim CG, Shin KM, Lim JS, Lim JK, Kim HJ, Kim WH, Cho SH, Cha SI, Lee EB, Seock Y and Jeong SY: Predictors of conversion to thoracotomy during video-assisted thoracoscopic surgery lobectomy in lung cancer: Additional predictive value of FDG-PET/CT in a tuberculosis endemic region. J Thorac Dis. 9:2427–2436. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Gensheimer MF, Hong JC, Chang-Halpenny C, Zhu H, Eclov NCW, To J, Murphy JD, Wakelee HA, Neal JW, Le QT, et al: Mid-radiotherapy PET/CT for prognostication and detection of early progression in patients with stage III non-small cell lung cancer. Radiother Oncol. 125:338–343. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Wu Q, Luo W, Zhao Y, Xu F and Zhou Q: The utility of 18F-FDG PET/CT for the diagnosis of adrenal metastasis in lung cancer: A PRISMA-compliant meta-analysis. Nucl Med Commun. 38:1117–1124. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Yuan N, Zhang X, Cao Y, Jiang X, Zhao S, Feng Y, Fan Y, Lu Z and Gao H: Contrast-enhanced computerized tomography combined with a targeted nanoparticle contrast agent for screening for early-phase non-small cell lung cancer. Exp Ther Med. 14:5063–5068. 2017.PubMed/NCBI

24 

Li N, Han L and Jing H: Contrast-enhanced ultrasound with a novel nanoparticle contrast agent for clinical diagnosis in patients with non-small cell lung cancer. Exp Ther Med. 14:3768–3773. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Nicholls FJ, Rotz MW, Ghuman H, MacRenaris KW, Meade TJ and Modo M: DNA-gadolinium-gold nanoparticles for in vivo T1 MR imaging of transplanted human neural stem cells. Biomaterials. 77:291–306. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Xiao L, Tian X, Harihar S, Li Q, Li L, Welch DR and Zhou A: Gd2O3-doped silica @ Au nanoparticles for in vitro imaging cancer biomarkers using surface-enhanced Raman scattering. Spectrochim Acta A Mol Biomol Spectrosc. 181:218–225. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Deng H, Chen F, Yang C, Chen M, Li L and Chen D: Effect of Eu doping concentration on fluorescence and magnetic resonance imaging properties of Gd2O3:Eu3+ nanoparticles used as dual-modal contrast agent. Nanotechnology. 29:4156012018. View Article : Google Scholar : PubMed/NCBI

28 

Zhang H, Wang T, Zheng Y, Yan C, Gu W and Ye L: Comparative toxicity and contrast enhancing assessments of Gd2O3@BSA and MnO2@BSA nanoparticles for MR imaging of brain glioma. Biochem Biophys Res Commun. 499:488–492. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Wirth LJ, Tahara M, Robinson B, Francis S, Brose MS, Habra MA, Newbold K, Kiyota N, Dutcus CE, Mathias E, et al: Treatment-emergent hypertension and efficacy in the phase 3 Study of (E7080) lenvatinib in differentiated cancer of the thyroid (SELECT). Cancer. 124:2365–2372. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Shao Y, Tian X, Hu W, Zhang Y, Liu H, He H, Shen Y, Xie F and Li L: The properties of Gd2O3-assembled silica nanocomposite targeted nanoprobes and their application in MRI. Biomaterials. 33:6438–6446. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Wojcik E and Kulpa JK: Pro-gastrin-releasing peptide (ProGRP) as a biomarker in small-cell lung cancer diagnosis, monitoring and evaluation of treatment response. Lung Cancer (Auckl). 8:231–240. 2017.PubMed/NCBI

32 

Reck M and Rabe KF: Precision diagnosis and treatment for advanced non-small-cell lung cancer. N Engl J Med. 377:849–861. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Zhou GH, Yang WH and Sun B: Clinical impact of serum miR-661 in diagnosis and prognosis of non-small cell lung cancer. Eur Rev Med Pharmacol Sci. 21:5696–5701. 2017.PubMed/NCBI

34 

Labbé C, Anderson M, Simard S, Tremblay L, Laberge F, Vaillancourt R and Lacasse Y: Wait times for diagnosis and treatment of lung cancer: A single-centre experience. Curr Oncol. 24:367–373. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Tzouvelekis A, Spagnolo P, Bonella F, Vancheri C, Tzilas V, Crestani B, Kreuter M and Bouros D: Patients with IPF and lung cancer: Diagnosis and management. Lancet Respir Med. 6:86–88. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Li Y, Jin G and Su D: Comparison of Gadolinium-enhanced MRI and 18FDG PET/PET-CT for the diagnosis of brain metastases in lung cancer patients: A meta-analysis of 5 prospective studies. Oncotarget. 8:35743–35749. 2017.PubMed/NCBI

37 

Wang H, Machtaler S, Bettinger T, Lutz AM, Luong R, Bussat P, Gambhir SS, Tranquart F, Tian L and Willmann JK: Molecular imaging of inflammation in inflammatory bowel disease with a clinically translatable dual-selectin-targeted US contrast agent: Comparison with FDG PET/CT in a mouse model. Radiology. 267:818–829. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Aschoff P, Plathow C, Beyer T, Lichy MP, Erb G, Öksüz MÖ, Claussen CD and Pfannenberg C: Multiphase contrast-enhanced CT with highly concentrated contrast agent can be used for PET attenuation correction in integrated PET/CT imaging. Eur J Nucl Med Mol Imaging. 39:316–325. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Hyafil F, Cornily JC, Rudd JH, Machac J, Feldman LJ and Fayad ZA: Quantification of inflammation within rabbit atherosclerotic plaques using the macrophage-specific CT contrast agent N1177: A comparison with 18F-FDG PET/CT and histology. J Nucl Med. 50:959–965. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Gao J, Li L, Liu X, Guo R and Zhao B: Contrast-enhanced magnetic resonance imaging with a novel nano-size contrast agent for the clinical diagnosis of patients with lung cancer. Exp Ther Med. 15:5415–5421. 2018.PubMed/NCBI

41 

An YS, Sheen SS, Oh YJ, Hwang SC and Yoon JK: Nonionic intravenous contrast agent does not cause clinically significant artifacts to 18F-FDG PET/CT in patients with lung cancer. Ann Nucl Med. 21:585–592. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Nishio M, Horai T, Horiike A, Nokihara H, Yamamoto N, Takahashi T, Murakami H, Yamamoto N, Koizumi F, Nishio K, et al: Phase 1 study of lenvatinib combined with carboplatin and paclitaxel in patients with non-small-cell lung cancer. Br J Cancer. 109:538–544. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Wu Y, Zhang H, Xiang J, Mao Z, Shen G, Yang F, Liu Y, Wang W, Du N, Zhang J and Tang Y: Ultrasensitive and high specific detection of non-small-cell lung cancer cells in human serum and clinical pleural effusion by aptamer-based fluorescence spectroscopy. Talanta. 179:501–506. 2018. View Article : Google Scholar : PubMed/NCBI

44 

Cai NL, Lau ATY, Yu FY, Wu DD, Dai LJ, Mo HY, Lin CM and Xu YM: Purification and characterization of a highly specific polyclonal antibody against human extracellular signal-regulated kinase 8 and its detection in lung cancer. PLoS One. 12:e01847552017. View Article : Google Scholar : PubMed/NCBI

45 

Sun Y, Liu S, Qiao Z, Shang Z, Xia Z, Niu X, Qian L, Zhang Y, Fan L, Cao CX and Xiao H: Systematic comparison of exosomal proteomes from human saliva and serum for the detection of lung cancer. Anal Chim Acta. 982:84–95. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Ohliger MA, von Morze C, Marco-Rius I, Gordon J, Larson PEZ, Bok R, Chen HY, Kurhanewicz J and Vigneron D: Combining hyperpolarized13 C MRI with a liver-specific gadolinium contrast agent for selective assessment of hepatocyte metabolism. Magn Reson Med. 77:2356–2363. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Uran S, Landmark K, Normann PT, Hals PA, Toft KG and Skotland T: A respiration-metabolism chamber system and a GC-MS method developed for studying exhalation of perfluorobutane in rats after intravenous injection of the ultrasound contrast agent Sonazoid. J Pharm Biomed Anal. 39:746–751. 2005. View Article : Google Scholar : PubMed/NCBI

48 

Skotland T, Sontum PC and Oulie I: In vitro stability analyses as a model for metabolism of ferromagnetic particles (Clariscan), a contrast agent for magnetic resonance imaging. J Pharm Biomed Anal. 28:323–329. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhou T, Hang D, Li Y, Zhang J, Wu H, Wang H, Tian E and Yan J: Role of Gd2O3‑doped carbon‑11‑choline‑lenvatinib nanoparticles contrast agent PET/CT in the diagnosis of patients with lung cancer. Oncol Lett 19: 1117-1124, 2020.
APA
Zhou, T., Hang, D., Li, Y., Zhang, J., Wu, H., Wang, H. ... Yan, J. (2020). Role of Gd2O3‑doped carbon‑11‑choline‑lenvatinib nanoparticles contrast agent PET/CT in the diagnosis of patients with lung cancer. Oncology Letters, 19, 1117-1124. https://doi.org/10.3892/ol.2019.11243
MLA
Zhou, T., Hang, D., Li, Y., Zhang, J., Wu, H., Wang, H., Tian, E., Yan, J."Role of Gd2O3‑doped carbon‑11‑choline‑lenvatinib nanoparticles contrast agent PET/CT in the diagnosis of patients with lung cancer". Oncology Letters 19.2 (2020): 1117-1124.
Chicago
Zhou, T., Hang, D., Li, Y., Zhang, J., Wu, H., Wang, H., Tian, E., Yan, J."Role of Gd2O3‑doped carbon‑11‑choline‑lenvatinib nanoparticles contrast agent PET/CT in the diagnosis of patients with lung cancer". Oncology Letters 19, no. 2 (2020): 1117-1124. https://doi.org/10.3892/ol.2019.11243
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou T, Hang D, Li Y, Zhang J, Wu H, Wang H, Tian E and Yan J: Role of Gd2O3‑doped carbon‑11‑choline‑lenvatinib nanoparticles contrast agent PET/CT in the diagnosis of patients with lung cancer. Oncol Lett 19: 1117-1124, 2020.
APA
Zhou, T., Hang, D., Li, Y., Zhang, J., Wu, H., Wang, H. ... Yan, J. (2020). Role of Gd2O3‑doped carbon‑11‑choline‑lenvatinib nanoparticles contrast agent PET/CT in the diagnosis of patients with lung cancer. Oncology Letters, 19, 1117-1124. https://doi.org/10.3892/ol.2019.11243
MLA
Zhou, T., Hang, D., Li, Y., Zhang, J., Wu, H., Wang, H., Tian, E., Yan, J."Role of Gd2O3‑doped carbon‑11‑choline‑lenvatinib nanoparticles contrast agent PET/CT in the diagnosis of patients with lung cancer". Oncology Letters 19.2 (2020): 1117-1124.
Chicago
Zhou, T., Hang, D., Li, Y., Zhang, J., Wu, H., Wang, H., Tian, E., Yan, J."Role of Gd2O3‑doped carbon‑11‑choline‑lenvatinib nanoparticles contrast agent PET/CT in the diagnosis of patients with lung cancer". Oncology Letters 19, no. 2 (2020): 1117-1124. https://doi.org/10.3892/ol.2019.11243
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