Open Access

Role of Gd2O3‑doped carbon‑11‑choline‑lenvatinib nanoparticles contrast agent PET/CT in the diagnosis of patients with lung cancer

  • Authors:
    • Tong Zhou
    • Dongfang Hang
    • Ying Li
    • Jin Zhang
    • Huayang Wu
    • Hongyan Wang
    • Enbing Tian
    • Jun Yan
  • View Affiliations

  • Published online on: December 23, 2019     https://doi.org/10.3892/ol.2019.11243
  • Pages: 1117-1124
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Positron emission tomography‑computed tomography (PET/CT) is an efficient method for the diagnosis of various types of human cancer. Studies have demonstrated that Gd2O3‑doped carbon‑11‑choline (GdCho) can be used as a contrast nanoparticle for PET/CT in the diagnosis of patients with lung cancer. The aim of the present study was to evaluate the effect of GdCho‑lenvatinib nanoparticles contrast‑PET/CT (GdCho‑Len‑PET) in the diagnosis and treatment planning of a cohort of patients suspected of having lung cancer. The results of the present study demonstrated that GdCho‑Len could be used as an efficient PET/CT contrast agent for the diagnosis of patients with lung cancer. GdCho‑Len nanoparticles contrast agent exhibited a significantly improved longitudinal relaxivity compared with GdCho. The outcomes of the present study were that GdCho‑Len‑PET diagnosed 152 patients with lung cancer, whereas GdCho‑PET diagnosed 130 patients with lung cancer among the 172 patients. GdCho‑Len‑PET presented with higher accuracy and sensitivity compared with GdCho‑PET in diagnosing patients with lung cancer. All patients were further confirmed via histological analysis. GdCho‑Len‑PET contributed to the anticancer treatments in 56 out of 62 (90.3%) patients with lung cancer who were candidates for radiation therapy, 52 out of 57 (91.2%) patients with lung cancer undergoing adjuvant radiotherapy, and 13 out of 17 (76.5%) patients with lung cancer undergoing comprehensive therapy. Patients diagnosed using GdCho‑Len‑PET improved the survival of patients with lung cancer during a 420‑day follow up. In conclusion, GdCho‑Len‑PET increased the diagnostic efficacy and had a significant effect on survival for patients with lung cancer, and may therefore serve as a reliable method for human cancer diagnosis.
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February-2020
Volume 19 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhou T, Hang D, Li Y, Zhang J, Wu H, Wang H, Tian E and Yan J: Role of Gd2O3‑doped carbon‑11‑choline‑lenvatinib nanoparticles contrast agent PET/CT in the diagnosis of patients with lung cancer. Oncol Lett 19: 1117-1124, 2020
APA
Zhou, T., Hang, D., Li, Y., Zhang, J., Wu, H., Wang, H. ... Yan, J. (2020). Role of Gd2O3‑doped carbon‑11‑choline‑lenvatinib nanoparticles contrast agent PET/CT in the diagnosis of patients with lung cancer. Oncology Letters, 19, 1117-1124. https://doi.org/10.3892/ol.2019.11243
MLA
Zhou, T., Hang, D., Li, Y., Zhang, J., Wu, H., Wang, H., Tian, E., Yan, J."Role of Gd2O3‑doped carbon‑11‑choline‑lenvatinib nanoparticles contrast agent PET/CT in the diagnosis of patients with lung cancer". Oncology Letters 19.2 (2020): 1117-1124.
Chicago
Zhou, T., Hang, D., Li, Y., Zhang, J., Wu, H., Wang, H., Tian, E., Yan, J."Role of Gd2O3‑doped carbon‑11‑choline‑lenvatinib nanoparticles contrast agent PET/CT in the diagnosis of patients with lung cancer". Oncology Letters 19, no. 2 (2020): 1117-1124. https://doi.org/10.3892/ol.2019.11243