Long non‑coding RNA BX357664 inhibits cell proliferation and metastasis in human lung cancer Corrigendum in /10.3892/ol.2021.12436

Xiao,Shu-Hui; Li,Gong-Xiang; Quan,Lingli

doi:10.3892/ol.2019.9886

Long non‑coding RNA BX357664 inhibits cell proliferation and metastasis in human lung cancer

Corrigendum in: /10.3892/ol.2021.12436

Authors:
- Shu-Hui Xiao
- Gong-Xiang Li
- Lingli Quan
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Affiliations: Department of Clinical Laboratory Medicine, The People's Hospital of Jinyi, Jinyi, Shanxi 710003, P.R. China, The First Department of Respiratory of Central Hospital of Zhuzhou, Zhuzhou, Hunan 412000, P.R. China
Published online on: January 3, 2019 https://doi.org/10.3892/ol.2019.9886
Pages: 2607-2614
Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Long non‑coding RNAs (lncRNAs) have been investigated in human carcinogenesis. The lncRNA BX357664 has emerged as a novel lncRNA that was initially recognized by a microarray analysis. The present study aimed to identify the expression and functional roles of lncRNA BX357664 in lung cancer. The transcription level of BX357664 was initially revealed to be downregulated in clinical lung cancer tissues and in a series of lung cancer cell lines. Clinical data demonstrated that the high expression of BX357664 was associated with tumor size, distant metastasis and Tumor‑Node‑Metastasis stage. Following the overexpression of BX357664 in A549 and 95D cells, the potential of cells to form colonies, as well as the proliferation and motility abilities, were revealed to be decreased. Furthermore, the cell cycle was arrested in the G0/G1 phase by BX357664 modulation. Transwell analysis and a wound‑healing assay also demonstrated that overexpression of BX357664 in A549 and 95D cells significantly inhibited cell migration and invasion. These data suggested that BX357664 inhibits cell proliferation and metastasis in lung cancer. The results of the present study provided evidence that BX357664 is a novel lncRNA that may aid in the diagnosis and treatment of lung cancer.

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