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Article Open Access

Mps1 is associated with the BRAFV600E mutation and predicts poor outcome in patients with colorectal cancer

  • Authors:
    • Yanyan Zhang
    • Jinyao Dong
    • Ruyi Shi
    • Liguo Feng
    • Yike Li
    • Caixia Cheng
    • Ling Zhang
    • Bin Song
    • Yanghui Bi
    • He Huang
    • Pengzhou Kong
    • Jiansheng Guo
    • Jing Liu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China, Endoscopy Center, Shanxi Cancer Hospital, Taiyuan, Shanxi 30013, P.R. China, Translational Medicine Research Center, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China, Department of General Surgery, Taiyuan Municipal No. 2 People's Hospital, Taiyuan, Shanxi 030002, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2809-2817
    |
    Published online on: January 14, 2019
       https://doi.org/10.3892/ol.2019.9924
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Abstract

Colorectal cancer (CRC) with the V600E mutation of B‑Raf proto‑oncogene serine/threonine kinase (BRAFV600E) mutation is insensitive to chemotherapy and is indicative of a poor patient prognosis. Although BRAF inhibitors have a marked effect on malignant melanoma harboring the BRAFV600E mutation, they have a limited effect on patients with CRC with the same BRAF mutation. A previous study identified a novel gene, monopolar spindle protein kinase 1 (Mps1), a downstream target of BRAFV600E only, rather than of wild‑type BRAF as well, which contributes to tumorigenesis in melanoma. In the present study, the incidence of BRAFV600E in patients with CRC was identified and the correlation of Mps1, phospho‑extracellular‑signal‑regulated kinase (p‑ERK) and BRAFV600E was investigated. The results indicated that the mutation rate of BRAFV600E was 5.2% in CRC. Poorly differentiated tumors and mucinous tumors have a significantly higher incidence of BRAFV600E compared with well‑differentiated tumors and non‑mucinous tumors (P<0.05). Kaplan‑Meier survival analysis indicated that the survival rate was markedly lower in patients with BRAFV600E compared with in patients with wild‑type BRAF (BRAFWT). The expression of p‑ERK and Mps1 in CRC with BRAFV600E was significantly higher compared with in CRC with BRAFWT (P<0.05), and their expression is associated with cancer classification, degree of differentiation and lymph node transfusion (P<0.05). In addition p‑ERK expression was positively correlated with Mps1 expression, with a contingency coefficient of 0.679 (P=0.002). In conclusion, the results of the present study indicated that Mps1 was significantly associated with BRAFV600E/p‑ERK and may serve a crucial function in the development of CRC. The results of the present study raise the possibility that targeting the oncogenic BRAF and Mps1, particularly when in conjunction, could provide promising therapeutic opportunities for the treatment of CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Dong J, Shi R, Feng L, Li Y, Cheng C, Zhang L, Song B, Bi Y, Huang H, Huang H, et al: Mps1 is associated with the BRAFV600E mutation and predicts poor outcome in patients with colorectal cancer. Oncol Lett 17: 2809-2817, 2019.
APA
Zhang, Y., Dong, J., Shi, R., Feng, L., Li, Y., Cheng, C. ... Liu, J. (2019). Mps1 is associated with the BRAFV600E mutation and predicts poor outcome in patients with colorectal cancer. Oncology Letters, 17, 2809-2817. https://doi.org/10.3892/ol.2019.9924
MLA
Zhang, Y., Dong, J., Shi, R., Feng, L., Li, Y., Cheng, C., Zhang, L., Song, B., Bi, Y., Huang, H., Kong, P., Guo, J., Liu, J."Mps1 is associated with the BRAFV600E mutation and predicts poor outcome in patients with colorectal cancer". Oncology Letters 17.3 (2019): 2809-2817.
Chicago
Zhang, Y., Dong, J., Shi, R., Feng, L., Li, Y., Cheng, C., Zhang, L., Song, B., Bi, Y., Huang, H., Kong, P., Guo, J., Liu, J."Mps1 is associated with the BRAFV600E mutation and predicts poor outcome in patients with colorectal cancer". Oncology Letters 17, no. 3 (2019): 2809-2817. https://doi.org/10.3892/ol.2019.9924
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Dong J, Shi R, Feng L, Li Y, Cheng C, Zhang L, Song B, Bi Y, Huang H, Huang H, et al: Mps1 is associated with the BRAFV600E mutation and predicts poor outcome in patients with colorectal cancer. Oncol Lett 17: 2809-2817, 2019.
APA
Zhang, Y., Dong, J., Shi, R., Feng, L., Li, Y., Cheng, C. ... Liu, J. (2019). Mps1 is associated with the BRAFV600E mutation and predicts poor outcome in patients with colorectal cancer. Oncology Letters, 17, 2809-2817. https://doi.org/10.3892/ol.2019.9924
MLA
Zhang, Y., Dong, J., Shi, R., Feng, L., Li, Y., Cheng, C., Zhang, L., Song, B., Bi, Y., Huang, H., Kong, P., Guo, J., Liu, J."Mps1 is associated with the BRAFV600E mutation and predicts poor outcome in patients with colorectal cancer". Oncology Letters 17.3 (2019): 2809-2817.
Chicago
Zhang, Y., Dong, J., Shi, R., Feng, L., Li, Y., Cheng, C., Zhang, L., Song, B., Bi, Y., Huang, H., Kong, P., Guo, J., Liu, J."Mps1 is associated with the BRAFV600E mutation and predicts poor outcome in patients with colorectal cancer". Oncology Letters 17, no. 3 (2019): 2809-2817. https://doi.org/10.3892/ol.2019.9924
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