Analysis of clinicopathological characteristics, MYB rearrangement and prognostic factors in salivary adenoid cystic carcinoma

  • Authors:
    • Jing Han
    • Chunye Zhang
    • Ting Gu
    • Xi Yang
    • Longwei Hu
    • Zhen Tian
    • Jiang Li
    • Chenping Zhang
  • View Affiliations

  • Published online on: January 15, 2019     https://doi.org/10.3892/ol.2019.9935
  • Pages: 2915-2922
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Abstract

Recent studies have indicated that a recurrent t(6;9)(q22‑23;p23‑24) chromosomal translocation in salivary adenoid cystic carcinoma (ACC) results in a MYB proto‑oncogene transcription factor‑nuclear factor I/B (MYB‑NFIB) gene fusion, which has not previously been detected in any non‑ACC carcinomas of the head and neck. In the present study, data on clinical factors affecting the survival rate of patients with salivary ACC from a single institution was retrospectively analyzed, and the frequency of MYB gene rearrangement determined. A total of 97 patient cases were analyzed, and young adults presenting with ACC (<40 years old) accounted for 19.6% of all patients (n=19). A total of 70.1% (n=68) displayed neurological symptoms, including pain, paraesthesia, tongue deviation, and facial paralysis. A marked majority of the analyzed tumors (85.6%) displayed evidence of MYB rearrangement. MYB rearrangement was significantly higher in patients with late Tumor‑Node‑Metastasis (TNM) stage cancer compared with that in patients with early TNM stage (P=0.033), as detected by a dual color MYB break‑apart fluorescence in situ hybridization probe. Kaplan‑Meier analysis revealed significant differences in patient overall survival (OS) time with regard to age, gender, TNM stage, neurological symptoms, margin status and MYB rearrangement. Specifically, young age was significantly associated with a shorter OS time. In summary, the present study suggested that young patients with salivary ACC presented with a worse prognosis, in contrast to the majority of patients with salivary ACC. Moreover, MYB alterations exhibited a high positive rate in salivary ACC, and therefore, the absence of MYB rearrangements may be associated with a better prognosis.
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March-2019
Volume 17 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Han J, Zhang C, Gu T, Yang X, Hu L, Tian Z, Li J and Zhang C: Analysis of clinicopathological characteristics, MYB rearrangement and prognostic factors in salivary adenoid cystic carcinoma. Oncol Lett 17: 2915-2922, 2019
APA
Han, J., Zhang, C., Gu, T., Yang, X., Hu, L., Tian, Z. ... Zhang, C. (2019). Analysis of clinicopathological characteristics, MYB rearrangement and prognostic factors in salivary adenoid cystic carcinoma. Oncology Letters, 17, 2915-2922. https://doi.org/10.3892/ol.2019.9935
MLA
Han, J., Zhang, C., Gu, T., Yang, X., Hu, L., Tian, Z., Li, J., Zhang, C."Analysis of clinicopathological characteristics, MYB rearrangement and prognostic factors in salivary adenoid cystic carcinoma". Oncology Letters 17.3 (2019): 2915-2922.
Chicago
Han, J., Zhang, C., Gu, T., Yang, X., Hu, L., Tian, Z., Li, J., Zhang, C."Analysis of clinicopathological characteristics, MYB rearrangement and prognostic factors in salivary adenoid cystic carcinoma". Oncology Letters 17, no. 3 (2019): 2915-2922. https://doi.org/10.3892/ol.2019.9935