Open Access

Cancer‑associated fibroblast regulation of tumor neo‑angiogenesis as a therapeutic target in cancer (Review)

  • Authors:
    • Fang‑Tao Wang
    • Wei Sun
    • Jing‑Tao Zhang
    • Yue‑Zu Fan
  • View Affiliations

  • Published online on: January 25, 2019     https://doi.org/10.3892/ol.2019.9973
  • Pages: 3055-3065
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Adequate blood supply is essential for tumor survival, growth and metastasis. The tumor microenvironment (TME) is dynamic and complex, comprising cancer cells, cancer‑associated stromal cells and their extracellular products. The TME serves an important role in tumor progression. Cancer‑associated fibroblasts (CAFs) are the principal component of stromal cells within the TME, and contribute to tumor neo‑angiogenesis by altering the proteome and degradome. The present paper reviews previous studies of the molecular signaling pathways by which CAFs promote tumor neo‑angiogenesis and highlights therapeutic response targets. Also discussed are potential strategies for antitumor neo‑angiogenesis to improve tumor treatment efficacy.
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March-2019
Volume 17 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Wang FT, Sun W, Zhang JT and Fan YZ: Cancer‑associated fibroblast regulation of tumor neo‑angiogenesis as a therapeutic target in cancer (Review). Oncol Lett 17: 3055-3065, 2019
APA
Wang, F., Sun, W., Zhang, J., & Fan, Y. (2019). Cancer‑associated fibroblast regulation of tumor neo‑angiogenesis as a therapeutic target in cancer (Review). Oncology Letters, 17, 3055-3065. https://doi.org/10.3892/ol.2019.9973
MLA
Wang, F., Sun, W., Zhang, J., Fan, Y."Cancer‑associated fibroblast regulation of tumor neo‑angiogenesis as a therapeutic target in cancer (Review)". Oncology Letters 17.3 (2019): 3055-3065.
Chicago
Wang, F., Sun, W., Zhang, J., Fan, Y."Cancer‑associated fibroblast regulation of tumor neo‑angiogenesis as a therapeutic target in cancer (Review)". Oncology Letters 17, no. 3 (2019): 3055-3065. https://doi.org/10.3892/ol.2019.9973