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MicroRNA‑218 inhibits the cell proliferation and migration in clear cell renal cell carcinoma through targeting cancerous inhibitor of protein phosphatase 2A

  • Authors:
    • Ruojing Wei
    • Xiongjun Ye
    • Yawei Zhao
    • Ning Jia
    • Tongwei Liu
    • Wenfeng Lian
    • Hongjian Wei
    • Gang Zhang
    • Lijie Song
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The First Central Hospital of Baoding, Baoding, Hebei 071000, P.R. China, Department of Urological Surgery, Beijing University People's Hospital, Beijing 100044, P.R. China, Department of Digestive Endoscopy Center, The Affiliated Hospital of Hebei University, Baoding, Hebei 071000, P.R. China
    Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3211-3218
    |
    Published online on: January 29, 2019
       https://doi.org/10.3892/ol.2019.9986
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Abstract

MicroRNAs (miRs) have emerged as critical modulators of tumor initiation and progression in numerous types of human cancer, including clear cell renal cell carcinoma (ccRCC), which is the most common subtype of renal cell carcinoma. Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a newly characterized oncoprotein and its overexpression has been reported to promote cellular epithelial‑mesenchymal transition and the tumor progression of ccRCC. The present study examined the effects of miR‑218 on CIP2A expression in ccRCC cells. The results demonstrated that the expression level of miR‑218 was lower in ccRCC tissues compared with that in adjacent non‑tumor renal tissues. In addition, it was identified that miR‑128 could directly bind to the 3'‑untranslated region of CIP2A. Furthermore, a negative correlation between the expression levels of miR‑218 and CIP2A was detected in ccRCC. Additionally, the down­regulation of CIP2A or overexpression of miR‑218 in ccRCC cells was revealed to inhibit cell proliferation and migration. In summary, these data suggest that miR‑218 serves a role in the regulation of CIP2A and elucidate its consequences on tumor progression, tumor cell proliferation and migration. These results indicate that miR‑218 may exhibit potential as a molecular target for the treatment of ccRCC.
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Copy and paste a formatted citation
Spandidos Publications style
Wei R, Ye X, Zhao Y, Jia N, Liu T, Lian W, Wei H, Zhang G and Song L: MicroRNA‑218 inhibits the cell proliferation and migration in clear cell renal cell carcinoma through targeting cancerous inhibitor of protein phosphatase 2A. Oncol Lett 17: 3211-3218, 2019.
APA
Wei, R., Ye, X., Zhao, Y., Jia, N., Liu, T., Lian, W. ... Song, L. (2019). MicroRNA‑218 inhibits the cell proliferation and migration in clear cell renal cell carcinoma through targeting cancerous inhibitor of protein phosphatase 2A. Oncology Letters, 17, 3211-3218. https://doi.org/10.3892/ol.2019.9986
MLA
Wei, R., Ye, X., Zhao, Y., Jia, N., Liu, T., Lian, W., Wei, H., Zhang, G., Song, L."MicroRNA‑218 inhibits the cell proliferation and migration in clear cell renal cell carcinoma through targeting cancerous inhibitor of protein phosphatase 2A". Oncology Letters 17.3 (2019): 3211-3218.
Chicago
Wei, R., Ye, X., Zhao, Y., Jia, N., Liu, T., Lian, W., Wei, H., Zhang, G., Song, L."MicroRNA‑218 inhibits the cell proliferation and migration in clear cell renal cell carcinoma through targeting cancerous inhibitor of protein phosphatase 2A". Oncology Letters 17, no. 3 (2019): 3211-3218. https://doi.org/10.3892/ol.2019.9986
Copy and paste a formatted citation
x
Spandidos Publications style
Wei R, Ye X, Zhao Y, Jia N, Liu T, Lian W, Wei H, Zhang G and Song L: MicroRNA‑218 inhibits the cell proliferation and migration in clear cell renal cell carcinoma through targeting cancerous inhibitor of protein phosphatase 2A. Oncol Lett 17: 3211-3218, 2019.
APA
Wei, R., Ye, X., Zhao, Y., Jia, N., Liu, T., Lian, W. ... Song, L. (2019). MicroRNA‑218 inhibits the cell proliferation and migration in clear cell renal cell carcinoma through targeting cancerous inhibitor of protein phosphatase 2A. Oncology Letters, 17, 3211-3218. https://doi.org/10.3892/ol.2019.9986
MLA
Wei, R., Ye, X., Zhao, Y., Jia, N., Liu, T., Lian, W., Wei, H., Zhang, G., Song, L."MicroRNA‑218 inhibits the cell proliferation and migration in clear cell renal cell carcinoma through targeting cancerous inhibitor of protein phosphatase 2A". Oncology Letters 17.3 (2019): 3211-3218.
Chicago
Wei, R., Ye, X., Zhao, Y., Jia, N., Liu, T., Lian, W., Wei, H., Zhang, G., Song, L."MicroRNA‑218 inhibits the cell proliferation and migration in clear cell renal cell carcinoma through targeting cancerous inhibitor of protein phosphatase 2A". Oncology Letters 17, no. 3 (2019): 3211-3218. https://doi.org/10.3892/ol.2019.9986
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