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Article

Knockdown of pseudogene DUXAP8 expression in glioma suppresses tumor cell proliferation

Corrigendum in: /10.3892/ol.2020.11859
  • Authors:
    • Xu Zhao
    • Shuai Hao
    • Minqing Wang
    • Deguang Xing
    • Chengwei Wang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China, Department of Neurosurgery, People's Hospital of Juye County, Juye, Shandong 274900, P.R. China
  • Pages: 3511-3516
    |
    Published online on: January 31, 2019
       https://doi.org/10.3892/ol.2019.9994
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Abstract

A large number of pseudogenes as well as long non‑coding RNAs (lncRNAs) have been identified as important regulators in human tumors. However, the clinical role and potential functional effects of the double homeobox A pseudogene 8 (DUXAP8) in glioma remains unknown. In the present study, it was revealed that pseudogene DUXAP8 is significantly upregulated in glioma tissues, compared with adjacent normal tissues. Patients with increased DUXAP8 expression were associated with higher Karnofsky Performance Status, advanced World Health Organization grade, poor disease‑free survival and overall survival rates of patients with glioma. Furthermore, in vitro assays, Cell‑Counting Kit‑8 cell viability and cell colony forming assays demonstrated that reduced DUXAP8 expression significantly suppressed proliferation capacity. Therefore, the results of the present study indicate that pseudogene DUXAP8 is an oncogenic lncRNA and may serve as a potentially prognostic biomarker and novel target of glioma treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao X, Hao S, Wang M, Xing D and Wang C: Knockdown of pseudogene DUXAP8 expression in glioma suppresses tumor cell proliferation Corrigendum in /10.3892/ol.2020.11859. Oncol Lett 17: 3511-3516, 2019.
APA
Zhao, X., Hao, S., Wang, M., Xing, D., & Wang, C. (2019). Knockdown of pseudogene DUXAP8 expression in glioma suppresses tumor cell proliferation Corrigendum in /10.3892/ol.2020.11859. Oncology Letters, 17, 3511-3516. https://doi.org/10.3892/ol.2019.9994
MLA
Zhao, X., Hao, S., Wang, M., Xing, D., Wang, C."Knockdown of pseudogene DUXAP8 expression in glioma suppresses tumor cell proliferation Corrigendum in /10.3892/ol.2020.11859". Oncology Letters 17.3 (2019): 3511-3516.
Chicago
Zhao, X., Hao, S., Wang, M., Xing, D., Wang, C."Knockdown of pseudogene DUXAP8 expression in glioma suppresses tumor cell proliferation Corrigendum in /10.3892/ol.2020.11859". Oncology Letters 17, no. 3 (2019): 3511-3516. https://doi.org/10.3892/ol.2019.9994
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao X, Hao S, Wang M, Xing D and Wang C: Knockdown of pseudogene DUXAP8 expression in glioma suppresses tumor cell proliferation Corrigendum in /10.3892/ol.2020.11859. Oncol Lett 17: 3511-3516, 2019.
APA
Zhao, X., Hao, S., Wang, M., Xing, D., & Wang, C. (2019). Knockdown of pseudogene DUXAP8 expression in glioma suppresses tumor cell proliferation Corrigendum in /10.3892/ol.2020.11859. Oncology Letters, 17, 3511-3516. https://doi.org/10.3892/ol.2019.9994
MLA
Zhao, X., Hao, S., Wang, M., Xing, D., Wang, C."Knockdown of pseudogene DUXAP8 expression in glioma suppresses tumor cell proliferation Corrigendum in /10.3892/ol.2020.11859". Oncology Letters 17.3 (2019): 3511-3516.
Chicago
Zhao, X., Hao, S., Wang, M., Xing, D., Wang, C."Knockdown of pseudogene DUXAP8 expression in glioma suppresses tumor cell proliferation Corrigendum in /10.3892/ol.2020.11859". Oncology Letters 17, no. 3 (2019): 3511-3516. https://doi.org/10.3892/ol.2019.9994
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