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Article Open Access

Analysis of circular RNA‑associated competing endogenous RNA network in breast cancer

  • Authors:
    • Xuekang Wang
    • Yanhan Dong
    • Qiong Wu
    • Tong Lu
    • Yuanyong Wang
    • Wenchao Liu
    • Chengyu Liu
    • Wenhua Xu
  • View Affiliations / Copyright

    Affiliations: Department of Inspection, Medical Faculty of Qingdao University, Qingdao, Shandong 266003, P.R. China, Center for Developmental Cardiology, Institute of Translational Medicine, College of Medicine, Qingdao University, Qingdao, Shandong 266021, P.R. China, Clinical Laboratory, Qingdao Hiser Medical Center, Qingdao, Shandong 266034, P.R. China, Department of Thoracic Surgery, Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China, Clinical Laboratory Blood Transfusion Service, Qingdao Municipal Hospital, Qingdao, Shandong 266011, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1619-1634
    |
    Published online on: January 2, 2020
       https://doi.org/10.3892/ol.2020.11247
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Abstract

As the most common type of cancer in female patients, the morbidity and mortality rates of breast cancer (BC) are high, and its incidence is gradually increasing worldwide. However, the underlying molecular and genetic mechanisms involved in the etiopathogenesis of BC remain unclear. Circular RNAs (circRNAs) are a novel type of non‑coding RNAs that have been verified to serve a crucial role in tumorigenesis. However, the majority of functions and mechanisms of circRNAs remain unknown. The present study identified 47 differentially expressed circRNAs in a dataset from Gene Expression Omnibus. Using the cancer‑specific circRNA database, the potential microRNA (miRNA) response elements, RNA‑binding proteins and open reading frames of the candidate circRNAs were predicted. Combing the predictions of miRNAs and target mRNAs, a competing endogenous RNA network was constructed, which may serve as the theoretical basis for further research. Furthermore, the analyses conducted using Gene Ontology terms and Kyoto Encyclopedia of Genes and Genomes pathways indicated that candidate circRNAs may serve a role in transcriptional regulation. Moreover, 20 BC tissue specimens and their paired adjacent normal tissue specimens were used to evaluate the expression levels of the screened circRNAs. Thus, the analyses of the raw microarray data conducted in the present study offer perspectives on the exploration of mechanisms associated with BC tumorigenesis with regard to the circRNA‑miRNA‑mRNA network.
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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Dong Y, Wu Q, Lu T, Wang Y, Liu W, Liu C and Xu W: Analysis of circular RNA‑associated competing endogenous RNA network in breast cancer. Oncol Lett 19: 1619-1634, 2020.
APA
Wang, X., Dong, Y., Wu, Q., Lu, T., Wang, Y., Liu, W. ... Xu, W. (2020). Analysis of circular RNA‑associated competing endogenous RNA network in breast cancer. Oncology Letters, 19, 1619-1634. https://doi.org/10.3892/ol.2020.11247
MLA
Wang, X., Dong, Y., Wu, Q., Lu, T., Wang, Y., Liu, W., Liu, C., Xu, W."Analysis of circular RNA‑associated competing endogenous RNA network in breast cancer". Oncology Letters 19.2 (2020): 1619-1634.
Chicago
Wang, X., Dong, Y., Wu, Q., Lu, T., Wang, Y., Liu, W., Liu, C., Xu, W."Analysis of circular RNA‑associated competing endogenous RNA network in breast cancer". Oncology Letters 19, no. 2 (2020): 1619-1634. https://doi.org/10.3892/ol.2020.11247
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Dong Y, Wu Q, Lu T, Wang Y, Liu W, Liu C and Xu W: Analysis of circular RNA‑associated competing endogenous RNA network in breast cancer. Oncol Lett 19: 1619-1634, 2020.
APA
Wang, X., Dong, Y., Wu, Q., Lu, T., Wang, Y., Liu, W. ... Xu, W. (2020). Analysis of circular RNA‑associated competing endogenous RNA network in breast cancer. Oncology Letters, 19, 1619-1634. https://doi.org/10.3892/ol.2020.11247
MLA
Wang, X., Dong, Y., Wu, Q., Lu, T., Wang, Y., Liu, W., Liu, C., Xu, W."Analysis of circular RNA‑associated competing endogenous RNA network in breast cancer". Oncology Letters 19.2 (2020): 1619-1634.
Chicago
Wang, X., Dong, Y., Wu, Q., Lu, T., Wang, Y., Liu, W., Liu, C., Xu, W."Analysis of circular RNA‑associated competing endogenous RNA network in breast cancer". Oncology Letters 19, no. 2 (2020): 1619-1634. https://doi.org/10.3892/ol.2020.11247
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