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High expression of citron kinase predicts poor prognosis of prostate cancer

  • Authors:
    • Junnan Liu
    • Jianguo Dou
    • Wujiao Wang
    • Hengchuan Liu
    • Yunlang Qin
    • Qixin Yang
    • Wencheng Jiang
    • Yong Liang
    • Yuejiang Liu
    • Jiang He
    • Li Mai
    • Ying Li
    • Delin Wang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China, Department of Urology, The People's Hospital of Dazu, Chongqing 400016, P.R. China, First Clinical Institute, Chongqing Medical University, Chongqing 400016, P.R. China, Department of Urology, The Zigong No. 4 People's Hospital, Zigong, Sichuan 643000, P.R. China, Department of Urology, The Zigong No. 1 People's Hospital, Zigong, Sichuan 643000, P.R. China, Gastroenterology and Neurology Center, University‑Town Hospital of Chongqing Medical University, Chongqing 400016, P.R. China, College of Life Science, Chongqing Medical University, Chongqing 400016, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1815-1823
    |
    Published online on: January 7, 2020
       https://doi.org/10.3892/ol.2020.11254
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Abstract

Citron kinase (CIT) is a Rho‑effector protein kinase that is associated with several types of cancer. However, the role of CIT in prostate cancer (PCa) is unclear. The current study utilized microarray data obtained from The Cancer Genome Atlas, which was analyzed via Biometric Research Program array tools. Additionally, reverse transcription‑quantitative (RT‑q)PCR was performed to compare the mRNA expression of CIT in PCa tissue and in benign prostatic hyperplasia. The protein expression of CIT was detected in a consecutive cohort via immunochemistry and CIT was screened as a potential oncogene in PCa. The results of RT‑qPCR demonstrated that the mRNA expression of CIT was increased in PCa tissues. Furthermore, immunochemistry revealed that CIT protein expression was positively associated with age at diagnosis, Gleason grade, serum PSA, clinical T stage, risk group, lymph node invasion and metastasis. When compared with the low expression group, patients with a high CIT expression exhibited shorter survival rates, cancer specific mortalities (CSM) and biochemical recurrence (BCR). In addition, multivariate analysis revealed that CIT was a potential predictor of CSM and BCR. The results revealed that CIT is overexpressed during the malignant progression of PCa and may be a predictor of a poor patient prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Liu J, Dou J, Wang W, Liu H, Qin Y, Yang Q, Jiang W, Liang Y, Liu Y, He J, He J, et al: High expression of citron kinase predicts poor prognosis of prostate cancer. Oncol Lett 19: 1815-1823, 2020.
APA
Liu, J., Dou, J., Wang, W., Liu, H., Qin, Y., Yang, Q. ... Wang, D. (2020). High expression of citron kinase predicts poor prognosis of prostate cancer. Oncology Letters, 19, 1815-1823. https://doi.org/10.3892/ol.2020.11254
MLA
Liu, J., Dou, J., Wang, W., Liu, H., Qin, Y., Yang, Q., Jiang, W., Liang, Y., Liu, Y., He, J., Mai, L., Li, Y., Wang, D."High expression of citron kinase predicts poor prognosis of prostate cancer". Oncology Letters 19.3 (2020): 1815-1823.
Chicago
Liu, J., Dou, J., Wang, W., Liu, H., Qin, Y., Yang, Q., Jiang, W., Liang, Y., Liu, Y., He, J., Mai, L., Li, Y., Wang, D."High expression of citron kinase predicts poor prognosis of prostate cancer". Oncology Letters 19, no. 3 (2020): 1815-1823. https://doi.org/10.3892/ol.2020.11254
Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Dou J, Wang W, Liu H, Qin Y, Yang Q, Jiang W, Liang Y, Liu Y, He J, He J, et al: High expression of citron kinase predicts poor prognosis of prostate cancer. Oncol Lett 19: 1815-1823, 2020.
APA
Liu, J., Dou, J., Wang, W., Liu, H., Qin, Y., Yang, Q. ... Wang, D. (2020). High expression of citron kinase predicts poor prognosis of prostate cancer. Oncology Letters, 19, 1815-1823. https://doi.org/10.3892/ol.2020.11254
MLA
Liu, J., Dou, J., Wang, W., Liu, H., Qin, Y., Yang, Q., Jiang, W., Liang, Y., Liu, Y., He, J., Mai, L., Li, Y., Wang, D."High expression of citron kinase predicts poor prognosis of prostate cancer". Oncology Letters 19.3 (2020): 1815-1823.
Chicago
Liu, J., Dou, J., Wang, W., Liu, H., Qin, Y., Yang, Q., Jiang, W., Liang, Y., Liu, Y., He, J., Mai, L., Li, Y., Wang, D."High expression of citron kinase predicts poor prognosis of prostate cancer". Oncology Letters 19, no. 3 (2020): 1815-1823. https://doi.org/10.3892/ol.2020.11254
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