Open Access

FBW7 in hematological tumors (Review)

  • Authors:
    • Qiaojuan Zhu
    • Linjun Hu
    • Yang Guo
    • Zunqiang Xiao
    • Qiuran Xu
    • Xiangmin Tong
  • View Affiliations

  • Published online on: January 8, 2020     https://doi.org/10.3892/ol.2020.11264
  • Pages: 1657-1664
  • Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

F‑box and WD repeat domain‑containing protein 7 (FBW7), also known as FBXW7, AGO or hCDC4, is an F‑box protein with seven tandem WD40 repeats. FBW7 is a key substrate recognition subunit of the Skp1‑Cul1‑F‑box‑protein E3 ubiquitin ligase. FBW7 targets for ubiquitination and destruction of numerous crucial transcription factors and protooncogenes, including cyclin E, c‑Myc, c‑Jun, Notch and MCL‑1. FBW7 is a well‑characterized tumor suppressor, and its gene is frequently mutated or deleted in various types of human cancer, including colorectal cancer, gastric cancer, ovarian cancer and different types of leukemia. Accumulating evidence indicates that the aberrant expression of FBW7 is involved in the development of hematological tumors, including T cell acute lymphoblastic leukemia, adult T cell leukemia/lymphoma, chronic lymphocytic leukemia and multiple myeloma. The present review will describe the latest findings on the role of FBW7 in hematological tumors, in order to identify a novel target for future therapies.

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March 2020
Volume 19 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Zhu, Q., Hu, L., Guo, Y., Xiao, Z., Xu, Q., & Tong, X. (2020). FBW7 in hematological tumors (Review). Oncology Letters, 19, 1657-1664. https://doi.org/10.3892/ol.2020.11264
MLA
Zhu, Q., Hu, L., Guo, Y., Xiao, Z., Xu, Q., Tong, X."FBW7 in hematological tumors (Review)". Oncology Letters 19.3 (2020): 1657-1664.
Chicago
Zhu, Q., Hu, L., Guo, Y., Xiao, Z., Xu, Q., Tong, X."FBW7 in hematological tumors (Review)". Oncology Letters 19, no. 3 (2020): 1657-1664. https://doi.org/10.3892/ol.2020.11264