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Article

Overexpression of long non‑coding RNA cancer susceptibility 11 is involved in the development of chemoresistance to carboplatin in hepatocellular carcinoma

  • Authors:
    • Haidong Liu
    • Tao Liu
    • Yong Zhou
    • Xinwen Song
    • Rendong Wei
  • View Affiliations / Copyright

    Affiliations: Department of Digestive Diseases, The Sixth People's Hospital of Qingdao, Qingdao, Shandong 266033, P.R. China, Department of Hepatology, The Sixth People's Hospital of Qingdao, Qingdao, Shandong 266033, P.R. China, Department of Infectious Diseases, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, P.R. China
  • Pages: 1993-1998
    |
    Published online on: January 8, 2020
       https://doi.org/10.3892/ol.2020.11265
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Abstract

The long non‑coding (lnc)RNA cancer susceptibility 11 (CASC11) promotes gastric cancer, however its role in other diseases is unknown. The present study demonstrated upregulation of lncRNA CASC11 and microRNA (miR)‑21 in hepatocellular carcinoma (HCC). Furthermore, the expression of CASC11 was positively correlated with that of miR‑21 in HCC tumors. Moreover, overexpression of lncRNA CASC11 led to upregulation of miR‑21 in HCC cells, whereas overexpression of miR‑21 had no effect on CASC11 levels. The levels of lncRNA CASC11 and miR‑21 were found to be upregulated in the plasma of patients with HCC during chemotherapy. In vitro cell experiments demonstrated upregulation of lncRNA CASC11 in HCC cells treated with carboplatin. Additionally, overexpression of lncRNA CASC11 promoted, whereas its knockdown inhibited the viability of HCC cells following carboplatin treatment. Finally, overexpression of miR‑21 ameliorated the effects of lncRNA CASC11 knockdown on cell viability. Thus, these findings suggest that upregulation of lncRNA CASC11 is involved in the development of chemoresistance to carboplatin in patients with HCC, via the upregulation of miR‑21.
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1 

Ryerson AB, Eheman CR, Altekruse SF, Ward JW, Jemal A, Sherman RL, Henley SJ, Holtzman D, Lake A, Noone AM, et al: Annual Report to the Nation on the Status of Cancer, 1975–2012, featuring the increasing incidence of liver cancer. Cancer. 122:1312–1337. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Altekruse SF, Henley SJ, Cucinelli JE and McGlynn KA: Changing hepatocellular carcinoma incidence and liver cancer mortality rates in the United States. Am J Gastroenterol. 109:542–553. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Wang H and Chen L: Tumor microenviroment and hepatocellular carcinoma metastasis. J Gastroenterol Hepatol. 28 (Suppl 1):S43–S48. 2013. View Article : Google Scholar

4 

Lee MH, Kim EJ, Lee H, Kim HM, Chang MJ, Park SY, Hong KS, Kim JS and Sessler JL: Liposomal texaphyrin theranostics for metastatic liver cancer. J Am Chem Soc. 138:16380–16387. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Zhao X, Chen Q, Liu W, Li Y, Tang H, Liu X and Yang X: Codelivery of doxorubicin and curcumin with lipid nanoparticles results in improved efficacy of chemotherapy in liver cancer. Int J Nanomedicine. 10:257–270. 2015.PubMed/NCBI

6 

Esteller M: Non-coding RNAs in human disease. Nat Rev Genet. 12:861–874. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Spizzo R, Almeida MI, Colombatti A and Calin GA: Long non-coding RNAs and cancer: A new frontier of translational research? Oncogene. 31:4577–4587. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Calin GA and Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer. 6:857–866. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Kumarswamy R, Volkmann I and Thum T: Regulation and function of miRNA-21 in health and disease. RNA Biol. 8:706–713. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Pan X, Wang ZX and Wang R: MicroRNA-21: a novel therapeutic target in human cancer. Cancer Biol Ther. 10:1224–1232. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Zhang L, Kang W, Lu X, Ma S, Dong L and Zou B: lncRNA CASC11 promoted gastric cancer cell proliferation, migration and invasion in vitro by regulating cell cycle pathway. Cell Cycle. 17:1886–1900. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Chun YS, Pawlik TM and Vauthey JN: 8th Edition of the AJCC cancer staging manual: Pancreas and hepatobiliary cancers. Ann Surg Oncol. 25:845–847. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Briz O, Perez MJ and Marin JJ: Further understanding of mechanisms involved in liver cancer chemoresistance. Hepatoma Res. 3:22–26. 2017. View Article : Google Scholar

15 

Mao B, Xiao H, Zhang Z, Wang D and Wang G: MicroRNA-21 regulates the expression of BTG2 in HepG2 liver cancer cells. Mol Med Rep. 12:4917–4924. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Wei J, Gao W, Zhu CJ, Liu YQ, Mei Z, Cheng T and Shu YQ: Identification of plasma microRNA-21 as a biomarker for early detection and chemosensitivity of non-small cell lung cancer. Chin J Cancer. 30:407–414. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Si X, Zang R, Zhang E, Liu Y, Shi X, Zhang E, Shao L, Li A, Yang N, Han X, et al: lncRNA H19 confers chemoresistance in ERα-positive breast cancer through epigenetic silencing of the pro-apoptotic gene BIK. Oncotarget. 7:81452–8146. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Shen CJ, Cheng YM and Wang CL: lncRNA PVT1 epigenetically silences miR-195 and modulates EMT and chemoresistance in cervical cancer cells. J Drug Target. 25:637–644. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Zhou X, Ye F, Yin C, Zhuang Y, Yue G and Zhang G: The interaction between miR-141 and lncRNA-H19 in regulating cell proliferation and migration in gastric cancer. Cell Physiol Biochem. 36:1440–1452. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Cao MX, Jiang YP, Tang YL and Liang XH: The crosstalk between lncRNA and microRNA in cancer metastasis: Orchestrating the epithelial-mesenchymal plasticity. Oncotarget. 8:12472–12483. 2017.PubMed/NCBI

21 

Zhang Z, Zhou C, Chang Y, Zhang Z, Hu Y, Zhang F, Lu Y, Zheng L, Zhang W and Li X and Li X: Long non-coding RNA CASC11 interacts with hnRNP-K and activates the WNT/β-catenin pathway to promote growth and metastasis in colorectal cancer. Cancer Lett. 376:62–73. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Wu D, Shi M and Fan XD: Mechanism of miR-21 via Wnt/β-catenin signaling pathway in human A549 lung cancer cells and Lewis lung carcinoma in mice. Asian Pac J Trop Med. 8:479–484. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu H, Liu T, Zhou Y, Song X and Wei R: Overexpression of long non‑coding RNA cancer susceptibility 11 is involved in the development of chemoresistance to carboplatin in hepatocellular carcinoma. Oncol Lett 19: 1993-1998, 2020.
APA
Liu, H., Liu, T., Zhou, Y., Song, X., & Wei, R. (2020). Overexpression of long non‑coding RNA cancer susceptibility 11 is involved in the development of chemoresistance to carboplatin in hepatocellular carcinoma. Oncology Letters, 19, 1993-1998. https://doi.org/10.3892/ol.2020.11265
MLA
Liu, H., Liu, T., Zhou, Y., Song, X., Wei, R."Overexpression of long non‑coding RNA cancer susceptibility 11 is involved in the development of chemoresistance to carboplatin in hepatocellular carcinoma". Oncology Letters 19.3 (2020): 1993-1998.
Chicago
Liu, H., Liu, T., Zhou, Y., Song, X., Wei, R."Overexpression of long non‑coding RNA cancer susceptibility 11 is involved in the development of chemoresistance to carboplatin in hepatocellular carcinoma". Oncology Letters 19, no. 3 (2020): 1993-1998. https://doi.org/10.3892/ol.2020.11265
Copy and paste a formatted citation
x
Spandidos Publications style
Liu H, Liu T, Zhou Y, Song X and Wei R: Overexpression of long non‑coding RNA cancer susceptibility 11 is involved in the development of chemoresistance to carboplatin in hepatocellular carcinoma. Oncol Lett 19: 1993-1998, 2020.
APA
Liu, H., Liu, T., Zhou, Y., Song, X., & Wei, R. (2020). Overexpression of long non‑coding RNA cancer susceptibility 11 is involved in the development of chemoresistance to carboplatin in hepatocellular carcinoma. Oncology Letters, 19, 1993-1998. https://doi.org/10.3892/ol.2020.11265
MLA
Liu, H., Liu, T., Zhou, Y., Song, X., Wei, R."Overexpression of long non‑coding RNA cancer susceptibility 11 is involved in the development of chemoresistance to carboplatin in hepatocellular carcinoma". Oncology Letters 19.3 (2020): 1993-1998.
Chicago
Liu, H., Liu, T., Zhou, Y., Song, X., Wei, R."Overexpression of long non‑coding RNA cancer susceptibility 11 is involved in the development of chemoresistance to carboplatin in hepatocellular carcinoma". Oncology Letters 19, no. 3 (2020): 1993-1998. https://doi.org/10.3892/ol.2020.11265
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