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THBS2, a microRNA‑744‑5p target, modulates MMP9 expression through CUX1 in pancreatic neuroendocrine tumors

  • Authors:
    • Heng Jiao
    • Lingxiao Zeng
    • Jianpeng Zhang
    • Shengsheng Yang
    • Wenhui Lou
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China, Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, P.R. China
    Copyright: © Jiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1683-1692
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    Published online on: January 9, 2020
       https://doi.org/10.3892/ol.2020.11273
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Abstract

The underlying molecular mechanisms of pancreatic neuroendocrine tumor (pNET) development have not yet been clearly identified. The present study revealed that thrombospondin 2 (THBS2) was downregulated in pNET tissues and cells. Forced expression of THBS2 inhibited the proliferation and migration of pNET cells in vitro. MicroRNA(miR)‑744‑5p was indicated to be a direct regulator of THBS2. Upregulation of miR‑744‑5p potentially caused THBS2 repression. Furthermore, THBS2 inhibited the production of matrix metalloproteinase (MMP) MMP9 through suppressing the transcriptional activity of CUT‑like homeobox 1 (CUX1). CUX1 and MMP9 mediated the effect of THBS2 on pNET proliferation and migration, respectively. The results of the present study revealed a mechanistic role for THBS2 in pNET proliferation and migration, indicating that THBS2 was downregulated by miR‑744‑5p and further affected the CUX1/MMP9 cascade, which promoted the development of pNET.
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Copy and paste a formatted citation
Spandidos Publications style
Jiao H, Zeng L, Zhang J, Yang S and Lou W: THBS2, a microRNA‑744‑5p target, modulates MMP9 expression through CUX1 in pancreatic neuroendocrine tumors. Oncol Lett 19: 1683-1692, 2020.
APA
Jiao, H., Zeng, L., Zhang, J., Yang, S., & Lou, W. (2020). THBS2, a microRNA‑744‑5p target, modulates MMP9 expression through CUX1 in pancreatic neuroendocrine tumors. Oncology Letters, 19, 1683-1692. https://doi.org/10.3892/ol.2020.11273
MLA
Jiao, H., Zeng, L., Zhang, J., Yang, S., Lou, W."THBS2, a microRNA‑744‑5p target, modulates MMP9 expression through CUX1 in pancreatic neuroendocrine tumors". Oncology Letters 19.3 (2020): 1683-1692.
Chicago
Jiao, H., Zeng, L., Zhang, J., Yang, S., Lou, W."THBS2, a microRNA‑744‑5p target, modulates MMP9 expression through CUX1 in pancreatic neuroendocrine tumors". Oncology Letters 19, no. 3 (2020): 1683-1692. https://doi.org/10.3892/ol.2020.11273
Copy and paste a formatted citation
x
Spandidos Publications style
Jiao H, Zeng L, Zhang J, Yang S and Lou W: THBS2, a microRNA‑744‑5p target, modulates MMP9 expression through CUX1 in pancreatic neuroendocrine tumors. Oncol Lett 19: 1683-1692, 2020.
APA
Jiao, H., Zeng, L., Zhang, J., Yang, S., & Lou, W. (2020). THBS2, a microRNA‑744‑5p target, modulates MMP9 expression through CUX1 in pancreatic neuroendocrine tumors. Oncology Letters, 19, 1683-1692. https://doi.org/10.3892/ol.2020.11273
MLA
Jiao, H., Zeng, L., Zhang, J., Yang, S., Lou, W."THBS2, a microRNA‑744‑5p target, modulates MMP9 expression through CUX1 in pancreatic neuroendocrine tumors". Oncology Letters 19.3 (2020): 1683-1692.
Chicago
Jiao, H., Zeng, L., Zhang, J., Yang, S., Lou, W."THBS2, a microRNA‑744‑5p target, modulates MMP9 expression through CUX1 in pancreatic neuroendocrine tumors". Oncology Letters 19, no. 3 (2020): 1683-1692. https://doi.org/10.3892/ol.2020.11273
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