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Expression and clinical significance of MAPK and EGFR in triple‑negative breast cancer

  • Authors:
    • Weihua Jiang
    • Xiaowen Wang
    • Chenguang Zhang
    • Laiti Xue
    • Liang Yang
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, The 3rd Affiliated Teaching Hospital of Xinjiang Medical University (Affiliated Cancer Hospital), Urumqi, Xinjiang 830011, P.R. China
    Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1842-1848
    |
    Published online on: January 9, 2020
       https://doi.org/10.3892/ol.2020.11274
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Abstract

To investigate the expression and clinical significance of mitogen‑activated protein kinase (MAPK) and epidermal growth factor receptor (EGFR) in triple‑negative breast cancer (TNBC), a total of 300 TNBC and 120 paired paracancerous tissues were examined. Immunohistochemistry was conducted to determine the expression levels of MAPK and EGFR, and the correlation between MAPK and EGFR expression was evaluated using Cramer's V test. The association between MAPK and EGFR expression, and various clinicopathological variables (such as lymph node metastasis, clinical stage, recurrence and metastasis) was also evaluated, using the χ2 test. MAPK and EGFR expression levels in TNBC tissues were significantly higher than in the paired paracancerous tissues. Moreover, MAPK expression was associated with that of EGFR in TNBC tissues. The positive expression rates of MAPK and EGFR in patients with lymph node metastasis, advanced clinical stage, tumor recurrence and metastasis were higher than those without. Patients with positive expression of MAPK and EGFR in TNBC tissues had poorer prognoses and lower overall survival times than those without expression. In summary, the expression of MAPK and EGFR is closely associated with tumor invasion and the metastasis of TNBC, and may therefore be used as an indicator of poor prognosis in patients with TNBC.
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1 

Corbex M, Bouzbid S, Traverse-Glehen A, Aouras H, McKay-Chopin S, Carreira C, Lankar A, Tommasino M and Gheit T: Prevalence of papillomaviruses, polyomaviruses, and herpesviruses in triple-negative and inflammatory breast tumors from algeria compared with other types of breast cancer tumors. PLoS One. 9:e1145592014. View Article : Google Scholar : PubMed/NCBI

2 

Collignon J, Lousberg L, Schroeder H and Jerusalem G: Triple-negative breast cancer: Treatment challenges and solutions. Breast Cancer (Dove Med Press). 8:93–107. 2016.PubMed/NCBI

3 

Maia AR, de Man J, Boon U, Janssen A, Song JY, Omerzu M, Sterrenburg JG, Prinsen MB, Willemsen-Seegers N, de Roos JA, et al: Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model. Ann Oncol. 26:2180–2192. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Sikov WM, Berry DA, Perou CM, Singh B, Cirrincione CT, Tolaney SM, Kuzma CS, Pluard TJ, Somlo G, Port ER, et al: Impact of the addition of carboplatin and/or bevacizumab to neoadjuvant once-per-week paclitaxel followed by dose-dense doxorubicin and cyclophosphamide on pathologic complete response rates in stage II to III triple-negative breast cancer: CALGB 40603 (Alliance). J Clin Oncol. 33:13–21. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Ali AM, Ansari JA, El-Aziz NMA, Abozeed WN, Warith AMA, Alsaleh K and Nabholtz JM: Triple negative breast cancer: A tale of two decades. Anticancer Agents Med Chem. 17:491–499. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Qi MS and Elion EA: MAP kinase pathways. J Cell Sci. 18:3569–3572. 2015.

7 

Zhang Y, Wei L, Yu J, Li G, Zhang X, Wang A, He Y, Li H and Yin D: Targeting of the β6 gene to suppress degradation of ECM via inactivation of the MAPK pathway in breast adenocarcinoma cells. Oncol Rep. 32:1787–1795. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Cotrim CZ, Fabris V, Doria ML, Lindberg K, Gustafsson JÅ, Amado F, Lanari C and Helguero LA: Estrogen receptor beta growth-inhibitory effects are repressed through activation of MAPK and PI3K signalling in mammary epithelial and breast cancer cells. Oncogene. 32:2390–2402. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Borah N, Gunawardana S, Torres H, McDonnell S and Van Slambrouck S: 5,6,7,3′,4′,5′-Hexamethoxyflavone inhibits growth of triple-negative breast cancer cells via suppression of MAPK and Akt signaling pathways and arresting cell cycle. Int J Oncol. 51:1685–1693. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Nalwoga H, Arnes JB, Wabinga H and Akslen LA: Expression of EGFR and c-kit is associated with the basal-like phenotype in breast carcinomas of African women. APMIS. 116:515–525. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Normanno N, Campiglio M, Maiello MR, De Luca A, Mancino M, Gallo M, D'Alessio A and Menard S: Breast cancer cells with acquired resistance to the EGFR tyrosine kinase inhibitor gefitinib show persistent activation of MAPK signaling. Breast Cancer Res Treat. 112:25–33. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Abdelrahman AE, Rashed HE, Abdelgawad M and Abdelhamid MI: Prognostic impact of EGFR and cytokeratin 5/6 immunohistochemical expression in triple-negative breast cancer. Ann Diagn Pathol. 28:43–53. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Shi Y, Yang F, Huang D and Guan X: Androgen blockade based clinical trials landscape in triple negative breast cancer. Biochim Biophys Acta Rev Cancer. 1870:283–290. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Kim S, You D, Jeong Y, Yu J, Kim SW, Nam SJ and Lee JE: Berberine down-regulates IL-8 expression through inhibition of the EGFR/MEK/ERK pathway in triple-negative breast cancer cells. Phytomedicine. 50:43–49. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Gholami S, Chen CH, Gao S, Lou E, Fujisawa S, Carson J, Nnoli JE, Chou TC, Bromberg J and Fong Y: Role of MAPK in oncolytic herpes viral therapy in triple-negative breast cancer. Cancer Gene Ther. 21:283–289. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Giltnane JM and Balko JM: Rationale for targeting the Ras/MAPK pathway in triple-negative breast cancer. Discov Med. 17:275–283. 2014.PubMed/NCBI

17 

Zhao M, Howard EW, Parris AB, Guo Z, Zhao Q and Yang X: Alcohol promotes migration and invasion of triple-negative breast cancer cells through activation of p38 MAPK and JNK. Mol Carcinog. 56:849–862. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Oh AS, Lorant LA, Holloway JN, Miller DL, Kern FG and El-Ashry D: Hyperactivation of MAPK induces loss of ERalpha expression in breast cancer cells. Mol Endocrinol. 15:1344–1359. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Majorini MT, Manenti G, Mano M, De Cecco L, Conti A, Pinciroli P, Fontanella E, Tagliabue E, Chiodoni C, Colombo MP, et al: cIAP1 regulates the EGFR/Snai2 axis in triple-negative breast cancer cells. Cell Death Differ. 25:2147–2164. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Jing W: Expression and significance of MAPK protein in breast cancer. Journal of Ningxia Medical College. 36:743–745. 2014.(In Chinese).

21 

Zenzola V, Cabezas-Quintario MA, Arguelles M, Pérez-Fernández E, Izarzugaza Y, Correa A and García-Foncillas J: Prognostic value of Ki-67 according to age in patients with triple-negative breast cancer. Clin Transl Oncol. 20:1448–1454. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Walsh EM, Shalaby A, O'Loughlin M, Keane N, Webber MJ, Kerin MJ, Keane MM, Glynn SA and Callagy GM: Outcome for triple negative breast cancer in a retrospective cohort with an emphasis on response to platinum-based neoadjuvant therapy. Breast Cancer Res Treat. 174:1–13. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Evans MK, Brown MC, Geradts J, Bao X, Robinson TJ, Jolly MK, Vermeulen PB, Palmer GM, Gromeier M, Levine H, et al: XIAP regulation by MNK links MAPK and NFκB signaling to determine an aggressive breast cancer phenotype. Cancer Res. 78:1726–1738. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Rakha EA, El-Sayed ME, Green AR, Lee AH, Robertson JF and Ellis IO: Prognostic markers in triple-negative breast cancer. Cancer. 109:25–32. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Shah SP, Roth A, Goya R, Oloumi A, Ha G, Zhao Y, Turashvili G, Ding J, Tse K, Haffari G, et al: The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature. 486:395–399. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Liu W, Zhang L, Shi J, Liu Y, Zhou L, Hou K, Qu X and Teng Y: Clinical significance of pAkt and pErk1/2 expression in early-stage breast cancer patients treated with anthracycline-based adjuvant chemotherapy. Oncol Lett. 9:1707–1714. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Ono H, Sowa Y, Horinaka M, Iizumi Y, Watanabe M, Morita M, Nishimoto E, Taguchi T and Sakai T: The histone deacetylase inhibitor OBP-801 and eribulin synergistically inhibit the growth of triple-negative breast cancer cells with the suppression of survivin, Bcl-xL, and the MAPK pathway. Breast Cancer Res Treat. 171:43–52. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Uehara N, Kanematsu S, Miki H, Yoshizawa K and Tsubura A: Requirement of p38 MAPK for a cell-death pathway triggered by vorinostat in MDA-MB-231 human breast cancer cells. Cancer Lett. 315:112–121. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Peng B, He R, Xu Q, Yang Y, Hu Q, Hou H, Liu X and Li J: Ginsenoside 20(S)-protopanaxadiol inhibits triple-negative breast cancer metastasis in vivo by targeting EGFR-mediated MAPK pathway. Pharmacol Res. 142:1–13. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jiang W, Wang X, Zhang C, Xue L and Yang L: Expression and clinical significance of MAPK and EGFR in triple‑negative breast cancer. Oncol Lett 19: 1842-1848, 2020.
APA
Jiang, W., Wang, X., Zhang, C., Xue, L., & Yang, L. (2020). Expression and clinical significance of MAPK and EGFR in triple‑negative breast cancer. Oncology Letters, 19, 1842-1848. https://doi.org/10.3892/ol.2020.11274
MLA
Jiang, W., Wang, X., Zhang, C., Xue, L., Yang, L."Expression and clinical significance of MAPK and EGFR in triple‑negative breast cancer". Oncology Letters 19.3 (2020): 1842-1848.
Chicago
Jiang, W., Wang, X., Zhang, C., Xue, L., Yang, L."Expression and clinical significance of MAPK and EGFR in triple‑negative breast cancer". Oncology Letters 19, no. 3 (2020): 1842-1848. https://doi.org/10.3892/ol.2020.11274
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang W, Wang X, Zhang C, Xue L and Yang L: Expression and clinical significance of MAPK and EGFR in triple‑negative breast cancer. Oncol Lett 19: 1842-1848, 2020.
APA
Jiang, W., Wang, X., Zhang, C., Xue, L., & Yang, L. (2020). Expression and clinical significance of MAPK and EGFR in triple‑negative breast cancer. Oncology Letters, 19, 1842-1848. https://doi.org/10.3892/ol.2020.11274
MLA
Jiang, W., Wang, X., Zhang, C., Xue, L., Yang, L."Expression and clinical significance of MAPK and EGFR in triple‑negative breast cancer". Oncology Letters 19.3 (2020): 1842-1848.
Chicago
Jiang, W., Wang, X., Zhang, C., Xue, L., Yang, L."Expression and clinical significance of MAPK and EGFR in triple‑negative breast cancer". Oncology Letters 19, no. 3 (2020): 1842-1848. https://doi.org/10.3892/ol.2020.11274
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