Open Access

Expression pattern of p‑Smad2/Smad4 as a predictor of survival in invasive breast ductal carcinoma

  • Authors:
    • Nannan Liu
    • Dongxue Qi
    • Jing Jiang
    • Jihong Zhang
    • Chunyan Yu
  • View Affiliations

  • Published online on: January 13, 2020     https://doi.org/10.3892/ol.2020.11297
  • Pages: 1789-1798
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study examined SMAD family member 4 (Smad4), SMAD family member 2 (Smad2) and phosphorylated (p‑)Smad2 expression in biopsy specimens from patients with invasive breast ductal carcinoma, in order to assess their abilities as prognostic markers. A total of 126 tissue samples were selected, and the expression of Smad2, p‑Smad2 and Smad4 in carcinoma tissues was detected by immunostaining, and the association between protein expression and clinicopathological variables was analyzed. Smad4 expression was negatively correlated with human epidermal growth factor receptor 2 in carcinoma tissues, and Smad4 expression was consistent with that of p‑Smad2. Although multivariate analysis revealed that Smad2, p‑Smad2 and Smad4 were not independent predictors, Kaplan‑Meier curves demonstrated that Smad4 positivity was correlated with a longer overall survival (OS) and progression‑free survival (PFS) time. However, upon analysis of combined markers, there was a significant difference between the p‑Smad2/Smad4 co‑positive and co‑negative patients; the latter tended to exhibit a shorter OS and PFS time, and multivariate analysis revealed that the combined expression of p‑Smad2 and Smad4 may be used as an independent prognostic factor. These results suggested that the assessment of p‑Smad2 and Smad4 protein expression in breast ductal carcinoma biopsy specimens may provide additional prognostic information.

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March 2020
Volume 19 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Liu, N., Qi, D., Jiang, J., Zhang, J., & Yu, C. (2020). Expression pattern of p‑Smad2/Smad4 as a predictor of survival in invasive breast ductal carcinoma. Oncology Letters, 19, 1789-1798. https://doi.org/10.3892/ol.2020.11297
MLA
Liu, N., Qi, D., Jiang, J., Zhang, J., Yu, C."Expression pattern of p‑Smad2/Smad4 as a predictor of survival in invasive breast ductal carcinoma". Oncology Letters 19.3 (2020): 1789-1798.
Chicago
Liu, N., Qi, D., Jiang, J., Zhang, J., Yu, C."Expression pattern of p‑Smad2/Smad4 as a predictor of survival in invasive breast ductal carcinoma". Oncology Letters 19, no. 3 (2020): 1789-1798. https://doi.org/10.3892/ol.2020.11297