Long noncoding RNA PLAC2 regulates PTEN in retinoblastoma and participates in the regulation of cancer cell apoptosis

Song,Ling; Qi,Yueqin; Lin,Ming

doi:10.3892/ol.2020.11314

Long noncoding RNA PLAC2 regulates PTEN in retinoblastoma and participates in the regulation of cancer cell apoptosis

Authors:
- Ling Song
- Yueqin Qi
- Ming Lin
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Affiliations: Department of Ophthalmology, Binzhou Hubin Aier Eye Hospital Limited, Binzhou, Shandong 256613, P.R. China, Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China
Published online on: January 17, 2020 https://doi.org/10.3892/ol.2020.11314
Pages: 2489-2494
Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Long noncoding RNA placenta‑specific 2 (PLAC2) blocks the cancer cell cycle in glioma, suggesting its tumor‑suppressive role. The present study aimed to investigate the role of PLAC2 in retinoblastoma (Rb). It was found that PLAC2 was downregulated in Rb tissues and was not affected by the development of Rb. PTEN was also downregulated in Rb and positively correlated with PLAC2. In Rb cells, PLAC2 over‑expression resulted in the upregulated expression of PTEN, while PTEN over‑expression did not affect PLAC2 expression. PLAC2 and PTEN over‑expression caused an increased apoptotic rate of Rb cells. PTEN small interfering RNA silencing led to a decreased apoptotic rate and attenuated the effects of PLAC2 over‑expression. Therefore, PLAC2 regulates PTEN in Rb and participates in the regulation of cancer cell apoptosis.

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