Open Access

Association of serum levels of deoxyribose 1‑phosphate and S‑lactoylglutathione with neoadjuvant chemotherapy sensitivity in patients with gastric cancer: A metabolomics study

  • Authors:
    • Daguang Wang
    • Wei Li
    • Lei Yin
    • Yechao Du
    • Shaopeng Zhang
    • Jian Suo
  • View Affiliations

  • Published online on: January 24, 2020     https://doi.org/10.3892/ol.2020.11350
  • Pages: 2231-2242
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study screened serum samples from patients with advanced‑stage gastric cancer and known sensitivities to neoadjuvant chemotherapy, in order to identify metabolites that may serve as potential biomarkers for chemotherapy sensitivity. A total of 47 patients with stage III (T4b) or IV gastric cancer, including 31 in the training group and 16 in a validation group, were classified based on their responses to conversion therapy consisting of oxaliplatin, tegafur and continuous hyperthermic peritoneal perfusion with cisplatin. Serum samples were analyzed by liquid chromatography‑mass spectrometry to obtain a metabolite profile of each patient. Patients who were responsive and non‑responsive to neoadjuvant chemotherapy exhibited significant differences in serum levels of deoxyribose 1‑phosphate, S‑lactoylglutathione, lysophosphatidylcholine (16:0) and O‑arachidonoyl ethanolamine. Logistic regression analysis indicated that deoxyribose 1‑phosphate and S‑lactoylglutathione were independently associated with chemosensitivity. Serum levels of deoxyribose 1‑phosphate and S‑lactoylglutathione were independently associated with the sensitivity of gastric cancer to neoadjuvant chemotherapy, therefore, serving as potential predictors of patient response.

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March 2020
Volume 19 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Wang, D., Li, W., Yin, L., Du, Y., Zhang, S., & Suo, J. (2020). Association of serum levels of deoxyribose 1‑phosphate and S‑lactoylglutathione with neoadjuvant chemotherapy sensitivity in patients with gastric cancer: A metabolomics study. Oncology Letters, 19, 2231-2242. https://doi.org/10.3892/ol.2020.11350
MLA
Wang, D., Li, W., Yin, L., Du, Y., Zhang, S., Suo, J."Association of serum levels of deoxyribose 1‑phosphate and S‑lactoylglutathione with neoadjuvant chemotherapy sensitivity in patients with gastric cancer: A metabolomics study". Oncology Letters 19.3 (2020): 2231-2242.
Chicago
Wang, D., Li, W., Yin, L., Du, Y., Zhang, S., Suo, J."Association of serum levels of deoxyribose 1‑phosphate and S‑lactoylglutathione with neoadjuvant chemotherapy sensitivity in patients with gastric cancer: A metabolomics study". Oncology Letters 19, no. 3 (2020): 2231-2242. https://doi.org/10.3892/ol.2020.11350