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Association of serum levels of deoxyribose 1‑phosphate and S‑lactoylglutathione with neoadjuvant chemotherapy sensitivity in patients with gastric cancer: A metabolomics study

  • Authors:
    • Daguang Wang
    • Wei Li
    • Lei Yin
    • Yechao Du
    • Shaopeng Zhang
    • Jian Suo
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Research Institute of Translational Medicine, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2231-2242
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    Published online on: January 24, 2020
       https://doi.org/10.3892/ol.2020.11350
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Abstract

The present study screened serum samples from patients with advanced‑stage gastric cancer and known sensitivities to neoadjuvant chemotherapy, in order to identify metabolites that may serve as potential biomarkers for chemotherapy sensitivity. A total of 47 patients with stage III (T4b) or IV gastric cancer, including 31 in the training group and 16 in a validation group, were classified based on their responses to conversion therapy consisting of oxaliplatin, tegafur and continuous hyperthermic peritoneal perfusion with cisplatin. Serum samples were analyzed by liquid chromatography‑mass spectrometry to obtain a metabolite profile of each patient. Patients who were responsive and non‑responsive to neoadjuvant chemotherapy exhibited significant differences in serum levels of deoxyribose 1‑phosphate, S‑lactoylglutathione, lysophosphatidylcholine (16:0) and O‑arachidonoyl ethanolamine. Logistic regression analysis indicated that deoxyribose 1‑phosphate and S‑lactoylglutathione were independently associated with chemosensitivity. Serum levels of deoxyribose 1‑phosphate and S‑lactoylglutathione were independently associated with the sensitivity of gastric cancer to neoadjuvant chemotherapy, therefore, serving as potential predictors of patient response.
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Copy and paste a formatted citation
Spandidos Publications style
Wang D, Li W, Yin L, Du Y, Zhang S and Suo J: Association of serum levels of deoxyribose 1‑phosphate and S‑lactoylglutathione with neoadjuvant chemotherapy sensitivity in patients with gastric cancer: A metabolomics study. Oncol Lett 19: 2231-2242, 2020.
APA
Wang, D., Li, W., Yin, L., Du, Y., Zhang, S., & Suo, J. (2020). Association of serum levels of deoxyribose 1‑phosphate and S‑lactoylglutathione with neoadjuvant chemotherapy sensitivity in patients with gastric cancer: A metabolomics study. Oncology Letters, 19, 2231-2242. https://doi.org/10.3892/ol.2020.11350
MLA
Wang, D., Li, W., Yin, L., Du, Y., Zhang, S., Suo, J."Association of serum levels of deoxyribose 1‑phosphate and S‑lactoylglutathione with neoadjuvant chemotherapy sensitivity in patients with gastric cancer: A metabolomics study". Oncology Letters 19.3 (2020): 2231-2242.
Chicago
Wang, D., Li, W., Yin, L., Du, Y., Zhang, S., Suo, J."Association of serum levels of deoxyribose 1‑phosphate and S‑lactoylglutathione with neoadjuvant chemotherapy sensitivity in patients with gastric cancer: A metabolomics study". Oncology Letters 19, no. 3 (2020): 2231-2242. https://doi.org/10.3892/ol.2020.11350
Copy and paste a formatted citation
x
Spandidos Publications style
Wang D, Li W, Yin L, Du Y, Zhang S and Suo J: Association of serum levels of deoxyribose 1‑phosphate and S‑lactoylglutathione with neoadjuvant chemotherapy sensitivity in patients with gastric cancer: A metabolomics study. Oncol Lett 19: 2231-2242, 2020.
APA
Wang, D., Li, W., Yin, L., Du, Y., Zhang, S., & Suo, J. (2020). Association of serum levels of deoxyribose 1‑phosphate and S‑lactoylglutathione with neoadjuvant chemotherapy sensitivity in patients with gastric cancer: A metabolomics study. Oncology Letters, 19, 2231-2242. https://doi.org/10.3892/ol.2020.11350
MLA
Wang, D., Li, W., Yin, L., Du, Y., Zhang, S., Suo, J."Association of serum levels of deoxyribose 1‑phosphate and S‑lactoylglutathione with neoadjuvant chemotherapy sensitivity in patients with gastric cancer: A metabolomics study". Oncology Letters 19.3 (2020): 2231-2242.
Chicago
Wang, D., Li, W., Yin, L., Du, Y., Zhang, S., Suo, J."Association of serum levels of deoxyribose 1‑phosphate and S‑lactoylglutathione with neoadjuvant chemotherapy sensitivity in patients with gastric cancer: A metabolomics study". Oncology Letters 19, no. 3 (2020): 2231-2242. https://doi.org/10.3892/ol.2020.11350
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