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miR‑939‑3p promotes epithelial‑mesenchymal transition and may be used as a prognostic marker in hepatocellular carcinoma

  • Authors:
    • Fei Chen
    • Xiaoying Ni
    • Lingxiu Chen
    • Xiaoyan Wang
    • Ji Xu
  • View Affiliations / Copyright

    Affiliations: Department of Digestive Center, Tiantai Branch of Zhejiang Provincial Peoples' Hospital, Taizhou, Zhejiang 317200, P.R. China, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial Peoples' Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310000, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2727-2732
    |
    Published online on: January 30, 2020
       https://doi.org/10.3892/ol.2020.11361
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Abstract

Hepatocellular carcinoma (HCC) is one of the most common types of cancer worldwide with a high morbidity and mortality rate. An increasing number of studies have demonstrated that microRNAs (miRNAs) serve an important role in HCC. The present study investigated the role of miR‑939‑3p in HCC. It was demonstrated that miR‑939‑3p was upregulated in HCC cell lines and HCC tissues compared with normal liver cell lines and paired normal tissues, respectively. It was also found that upregulation of miR‑939‑3p expression levels in HCC tissues was associated with a less favorable prognosis. Moreover, the overexpression of miR‑939‑3p in LM3 cells enhanced the metastatic capacity of these cells and promoted epithelial‑mesenchymal transition (EMT). In contrast, miR‑939‑3p inhibition decreased the invasive capacity of HCC cells and EMT. Potential binding target of miR‑939‑3p to estrogen receptor 1 (ESR1) were predicted using TargetScan. The expression levels of miR‑939‑3p were negatively associated with ESR1 in HCC tissues based on data from The Cancer Genome Atlas. A luciferase reporter assay was used to confirm ESR1 as a direct downstream target of miR‑393‑3p. The miR‑939‑3p/ESR1 axis may be a potential novel target for the treatment of HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Chen F, Ni X, Chen L, Wang X and Xu J: miR‑939‑3p promotes epithelial‑mesenchymal transition and may be used as a prognostic marker in hepatocellular carcinoma. Oncol Lett 19: 2727-2732, 2020.
APA
Chen, F., Ni, X., Chen, L., Wang, X., & Xu, J. (2020). miR‑939‑3p promotes epithelial‑mesenchymal transition and may be used as a prognostic marker in hepatocellular carcinoma. Oncology Letters, 19, 2727-2732. https://doi.org/10.3892/ol.2020.11361
MLA
Chen, F., Ni, X., Chen, L., Wang, X., Xu, J."miR‑939‑3p promotes epithelial‑mesenchymal transition and may be used as a prognostic marker in hepatocellular carcinoma". Oncology Letters 19.4 (2020): 2727-2732.
Chicago
Chen, F., Ni, X., Chen, L., Wang, X., Xu, J."miR‑939‑3p promotes epithelial‑mesenchymal transition and may be used as a prognostic marker in hepatocellular carcinoma". Oncology Letters 19, no. 4 (2020): 2727-2732. https://doi.org/10.3892/ol.2020.11361
Copy and paste a formatted citation
x
Spandidos Publications style
Chen F, Ni X, Chen L, Wang X and Xu J: miR‑939‑3p promotes epithelial‑mesenchymal transition and may be used as a prognostic marker in hepatocellular carcinoma. Oncol Lett 19: 2727-2732, 2020.
APA
Chen, F., Ni, X., Chen, L., Wang, X., & Xu, J. (2020). miR‑939‑3p promotes epithelial‑mesenchymal transition and may be used as a prognostic marker in hepatocellular carcinoma. Oncology Letters, 19, 2727-2732. https://doi.org/10.3892/ol.2020.11361
MLA
Chen, F., Ni, X., Chen, L., Wang, X., Xu, J."miR‑939‑3p promotes epithelial‑mesenchymal transition and may be used as a prognostic marker in hepatocellular carcinoma". Oncology Letters 19.4 (2020): 2727-2732.
Chicago
Chen, F., Ni, X., Chen, L., Wang, X., Xu, J."miR‑939‑3p promotes epithelial‑mesenchymal transition and may be used as a prognostic marker in hepatocellular carcinoma". Oncology Letters 19, no. 4 (2020): 2727-2732. https://doi.org/10.3892/ol.2020.11361
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