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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
April-2020 Volume 19 Issue 4

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Journal Metrics

Impact Factor: 2.2

CiteScore: 4.6

CiteScore Rank: Q2: #178/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.568

SCImago Journal Rank (SJR): 0.663

Review Open Access

Overview of the STAT‑3 signaling pathway in cancer and the development of specific inhibitors (Review)

Yuchen Gu, Imran Shair Mohammad, Zhe Liu
Pages: 2585-2594
Published online on: 13 February 2020

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Review Open Access

Role and mechanism of programmed death‑ligand 1 in hypoxia‑induced liver cancer immune escape (Review)

Qingxian Wen, Tao Han, Zijian Wang, Shulong Jiang
Pages: 2595-2601
Published online on: 05 February 2020

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Article Open Access

Podoplanin is an efficient predictor of neck lymph node metastasis in tongue squamous cell carcinoma with low tumor budding grade

Mei Hamada, Yasuhiro Ebihara, Koji Nagata, Mitsutake Yano, Yasunao Kogashiwa, Mitsuhiko Nakahira, Masashi Sugasawa, Hitoshi Nagatsuka, Masanori Yasuda
Pages: 2602-2608
Published online on: 29 January 2020

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Article Open Access

Association between G‑protein coupled receptor 4 expression and microvessel density, clinicopathological characteristics and survival in hepatocellular carcinoma

Chaofan Xue, Shuai Shao, Yanli Yan, Si Yang, Shuheng Bai, Yinying Wu, Jiangzhou Zhang, Rui Liu, Hailin Ma, Linyan Chai, Xiaozhi Zhang, Juan Ren
Pages: 2609-2620
Published online on: 05 February 2020

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Article Open Access

Maspin inhibits MCF‑7 cell invasion and proliferation by downregulating miR‑21 and increasing the expression of its target genes

Shao‑Xin Huang, Wen‑Yan Fan, Ling Wang, Hui Liu, Xin Wang, Hao Zhao, Wen‑Bin Jiang
Pages: 2621-2628
Published online on: 30 January 2020

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Article Open Access

Pharmacological ascorbate induces ‘BRCAness’ and enhances the effects of Poly(ADP‑Ribose) polymerase inhibitors against BRCA1/2 wild‑type ovarian cancer

Yan Ma, Ping Chen, Jeanne A. Drisko, Dineo Khabele, Andrew K. Godwin, Qi Chen
Pages: 2629-2638
Published online on: 31 January 2020

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Article Open Access

Decreased IL‑37 expression in hepatocellular carcinoma tissues and liver cancer cell lines

Peng Li, Hongsheng Guo, Kun Wu, Liudan Su, Kai Huang, Ruizhi Lai, Ziliang Deng, Shuxian Li, Ping Ouyang, Yan Wang, Zhangquan Chen, Guangji Zhou, Sen Wang
Pages: 2639-2648
Published online on: 13 February 2020

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Article Open Access

Interferon‑β sensitizes human glioblastoma cells to the cyclin‑dependent kinase inhibitor, TG02

Birthe Lohmann, Emilie Le Rhun, Manuela Silginer, Mirka Epskamp, Michael Weller
Pages: 2649-2656
Published online on: 30 January 2020

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Article Open Access

Usefulness of plasma full‑length glypican‑3 as a predictive marker of hepatocellular carcinoma recurrence after radial surgery

Masahiro Miura, Norihiro Fujinami, Yasuhiro Shimizu, Shoichi Mizuno, Keigo Saito, Toshihiro Suzuki, Masaru Konishi, Shinichiro Takahashi, Naoto Gotohda, Kouzou Suto, Tomokazu Yoshida, Tetsuya Nakatsura
Pages: 2657-2666
Published online on: 05 February 2020

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Article Open Access

Indication of suitable transarterial chemoembolization and multikinase inhibitors for intermediate stage hepatocellular carcinoma

Shigeo Shimose, Takumi Kawaguchi, Hideki Iwamoto, Takashi Niizeki, Tomotake Shirono, Masatoshi Tanaka, Hironori Koga, Takuji Torimura
Pages: 2667-2676
Published online on: 17 February 2020

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Article Open Access

miR‑3940‑5p/miR‑8069 ratio in urine exosomes is a novel diagnostic biomarker for pancreatic ductal adenocarcinoma

Naohiko Yoshizawa, Kazushi Sugimoto, Masahiko Tameda, Yuji Inagaki, Makoto Ikejiri, Hiroyuki Inoue, Masanobu Usui, Masaaki Ito, Yoshiyuki Takei
Pages: 2677-2684
Published online on: 29 January 2020

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Article Open Access

Upregulation of microRNA‑31 is associated with poor prognosis in patients with advanced colorectal cancer

Nobuhito Kubota, Fumitaka Taniguchi, Akihiro Nyuya, Yuzo Umeda, Yoshiko Mori, Toshiyoshi Fujiwara, Hiroaki Tanioka, Atsushi Tsuruta, Yoshiyuki Yamaguchi, Takeshi Nagasaka
Pages: 2685-2694
Published online on: 03 February 2020

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Article Open Access

Salvage stereotactic body radiotherapy for post‑operative oligo‑recurrence of non‑small cell lung cancer: A single‑institution analysis of 59 patients

Shuri Aoki, Hideomi Yamashita, Wataru Takahashi, Kanabu Nawa, Takeshi Ota, Toshikazu Imae, Sho Ozaki, Yuki Nozawa, Jun Nakajima, Masaaki Sato, Masaki Anraku, Junichi Nitadori, Takahiro Karasaki, Osamu Abe, Keiichi Nakagawa
Pages: 2695-2704
Published online on: 17 February 2020

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Article Open Access

The pathological complete response and secreted protein acidic and rich in cysteine expression in patients with breast cancer receiving neoadjuvant nab‑paclitaxel chemotherapy

Yuko Nakazawa, Seshiru Nakazawa, Sasagu Kurozumi, Misato Ogino, Yukio Koibuchi, Hiroki Odawara, Tetsunari Oyama, Jun Horiguchi, Takaaki Fujii, Ken Shirabe
Pages: 2705-2712
Published online on: 27 January 2020

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Article Open Access

Changes in the gene mutation profiles of circulating tumor DNA detected using CAPP‑Seq in neoadjuvant chemotherapy‑treated advanced ovarian cancer

Tomoko Noguchi, Kazuko Sakai, Naoyuki Iwahashi, Kaho Matsuda, Hitomi Matsukawa, Tamaki Yahata, Saori Toujima, Kazuto Nishio, Kazuhiko Ino
Pages: 2713-2720
Published online on: 28 January 2020

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Article Open Access

lncRNA SNHG7 promotes tumorigenesis of nasopharyngeal carcinoma via epithelial‑to‑mesenchymal transition Retraction in /10.3892/ol.2020.11949

Wenrui Xu, Xiaohan Sun, Chuanshan Zang, Yan Jiang
Pages: 2721-2726
Published online on: 14 February 2020

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Article Open Access

miR‑939‑3p promotes epithelial‑mesenchymal transition and may be used as a prognostic marker in hepatocellular carcinoma

Fei Chen, Xiaoying Ni, Lingxiu Chen, Xiaoyan Wang, Ji Xu
Pages: 2727-2732
Published online on: 30 January 2020

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Article Open Access

Influence of combined epidural anesthesia on cognitive function, inflammation and stress response in elderly liver cancer patients undergoing surgery

Yang Su, Yanan Pu, Zhengnan Zhao, Xianglong Yang
Pages: 2733-2738
Published online on: 14 February 2020

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Article Open Access

Implications of driver genes associated with a high tumor mutation burden identified using next‑generation sequencing on immunotherapy in hepatocellular carcinoma

Li Li, Xiaosong Rao, Zhaohong Wen, Xiaosheng Ding, Xiangyi Wang, Weiran Xu, Chao Meng, Yuting Yi, Yanfang Guan, Yongshen Chen, Jiayin Wang, Liang Jun
Pages: 2739-2748
Published online on: 05 February 2020

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Article Open Access

SMAD3 promotes ELK3 expression following transforming growth factor β‑mediated stimulation of MDA‑MB231 cells

Ji‑Hoon Park, Kyung‑Soon Park
Pages: 2749-2754
Published online on: 06 February 2020

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Article Open Access

Expression of Foxp3 and interleukin‑7 receptor and clinicopathological characteristics of patients with diffuse large B‑cell lymphoma

Yan Zhao, Wen‑Li Cui, Zhi‑Yin Feng, Jing Xue, Abulajiang Gulinaer, Wei Zhang
Pages: 2755-2764
Published online on: 06 February 2020

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Article Open Access

Upregulation of MYBL2 independently predicts a poorer prognosis in patients with clear cell renal cell carcinoma

Shan‑Shan Sun, Yang Fu, Jian‑Yang Lin
Pages: 2765-2772
Published online on: 17 February 2020

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Article Open Access

Ubiquitin‑like modifier‑activating enzyme 7 as a marker for the diagnosis and prognosis of breast cancer

Meng Lin, Yanqing Li, Shanshan Qin, Yan Jiao, Fang Hua
Pages: 2773-2784
Published online on: 17 February 2020

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Article Open Access

Evaluation of kininogen 1, osteopontin and α‑1‑antitrypsin in plasma, bronchoalveolar lavage fluid and urine for lung squamous cell carcinoma diagnosis

Weiwei Wang, Shanshan Wang, Man Zhang
Pages: 2785-2792
Published online on: 06 February 2020

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Article Open Access

Identification of a long non‑coding RNA signature for predicting prognosis and biomarkers in lung adenocarcinoma

Xiaolin Yu, Yanxia Zhang
Pages: 2793-2800
Published online on: 17 February 2020

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Article Open Access

4‑methylumbelliferone inhibits clonogenic potency by suppressing high molecular weight‑hyaluronan in fibrosarcoma cells

Kazuki Hasegawa, Ryo Saga, Rei Takahashi, Roman Fukui, Mitsuru Chiba, Kazuhiko Okumura, Eichi Tsuruga, Yoichiro Hosokawa
Pages: 2801-2808
Published online on: 05 February 2020

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Article Open Access

A novel anti‑EGFR monoclonal antibody (EMab‑17) exerts antitumor activity against oral squamous cell carcinomas via antibody‑dependent cellular cytotoxicity and complement‑dependent cytotoxicity

Junko Takei, Mika Kato Kaneko, Tomokazu Ohishi, Manabu Kawada, Hiroyuki Harada, Yukinari Kato
Pages: 2809-2816
Published online on: 10 February 2020

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Article Open Access

Gene expression profiling identified TP53MutPIK3CAWild as a potential biomarker for patients with triple‑negative breast cancer treated with immune checkpoint inhibitors

Jia'nan Cheng, Xiaofang Ding, Shouxia Xu, Bo Zhu, Qingzhu Jia
Pages: 2817-2824
Published online on: 10 February 2020

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Article Open Access

PEBP4 gene expression in lung squamous cell carcinoma: A meta‑analysis‑based study of the molecular pathways involved

Guiping Yu, Ning Zhong, Bin Huang, Yedong Mi
Pages: 2825-2831
Published online on: 12 February 2020

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Article Open Access

LINK‑A lncRNA is upregulated in osteosarcoma and regulates migration, invasion and stemness of osteosarcoma cells

Yao Kong, Zhikui Nie, Hongmin Guo, Cao Ma
Pages: 2832-2838
Published online on: 05 February 2020

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Article Open Access

Knockdown of long non‑coding RNA prostate cancer‑associated transcript 1 inhibits the proliferation and metastasis of tongue squamous cell carcinoma cells by upregulating p21

Ming Yan, Tianjiang Zhao, Lingling Fu, Rongxiang Tian, Dongzhen Li, Yunmeng Da
Pages: 2839-2845
Published online on: 06 February 2020

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Article Open Access

Identification of hub genes associated with outcome of clear cell renal cell carcinoma

Rengui Li, Lei Wang, Xiao Wang, Rong‑Xin Geng, Ning Li, Xiu‑Heng Liu
Pages: 2846-2860
Published online on: 12 February 2020

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Article Open Access

Effect of HBx on inflammation and mitochondrial oxidative stress in mouse hepatocytes

Li‑Rong Ling, Dan‑Hua Zheng, Zhi‑Yang Zhang, Wen‑Hui Xie, Yue‑Hong Huang, Zhi‑Xin Chen, Xiao‑Zhong Wang, Dan Li
Pages: 2861-2869
Published online on: 17 February 2020

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Article Open Access

GEM on proliferation and apoptosis of childhood AL cells through inhibiting c‑myc expression by upregulating miR‑125a‑3p

Weiwei Xing, Yuxia Yin, Saina Yang, Guang Lu
Pages: 2870-2874
Published online on: 14 February 2020

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Article Open Access

C‑C motif chemokine 14 as a novel potential biomarker for predicting the prognosis of epithelial ovarian cancer

Yubo Cai, Yihong Ling, Lingbo Huang, Hui Huang, Xianlan Chen, Yongbo Xiao, Zhongmei Zhu, Jiewei Chen
Pages: 2875-2883
Published online on: 07 February 2020

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Article Open Access

De novo metastatic breast cancer: Subgroup analysis of molecular subtypes and prognosis

Li Zhang, Zhijun Li, Jie Zhang, Yansheng Wu, Yuying Zhu, Zhongsheng Tong
Pages: 2884-2894
Published online on: 30 January 2020

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Article Open Access

RBBP6 induces non‑small cell lung cancer cell proliferation and high expression is associated with poor prognosis

Qiu‑Shi Wang, Shi‑Rong Wei, Hua‑Liang Xiao
Pages: 2895-2901
Published online on: 17 February 2020

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Article Open Access

MicroRNA‑212 suppresses cell proliferation in nasopharyngeal carcinoma by targeting ELF3

Yaojie Kang, Yanfei Cui, Ming Tan
Pages: 2902-2908
Published online on: 17 February 2020

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Article Open Access

Effects of CDK6 regulated by miR‑298 on proliferation and apoptosis of thyroid cancer cells

Xinyan Li, Cuicui Liu, Xiumei Zhao, Rui Wang, Na Gu, Hongsheng Shen, Xijing Li, Luyao Wang, Chao Li
Pages: 2909-2915
Published online on: 14 February 2020

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Article Open Access

BCL11A confers cell invasion and migration in androgen receptor‑positive triple‑negative breast cancer

Xin Wang, Yumei Xu, Kun Xu, Yajuan Chen, Xiudi Xiao, Xiaoxiang Guan
Pages: 2916-2924
Published online on: 10 February 2020

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Article Open Access

Heavy metals interfere with plasma metabolites, including lipids and amino acids, in patients with breast cancer

Ling Li, Meihua Zhang, Yuhao Men, Wei Wang, Weidong Zhang
Pages: 2925-2933
Published online on: 17 February 2020

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Article Open Access

Intratumoral heterogeneity of glutaminase and lactate dehydrogenase A protein expression in colorectal cancer

Yuta Mizuno, Kimiaki Hattori, Kohei Taniguchi, Keitaro Tanaka, Kazuhisa Uchiyama, Yoshinobu Hirose
Pages: 2934-2942
Published online on: 13 February 2020

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Article Open Access

Timing of changing therapy from gemcitabine and cisplatin chemotherapy based on real‑world data of advanced urothelial carcinoma

Nobuki Furubayashi, Takahito Negishi, Dai Takamatsu, Kosuke Ieiri, Tomohiro Inoue, Keiji Tsukino, Motonobu Nakamura
Pages: 2943-2949
Published online on: 05 February 2020

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Article Open Access

Rapamycin inhibits proliferation and apoptosis of retinoblastoma cells through PI3K/AKT signaling pathway

Jun Yao, Min Xu, Ziyao Liu
Pages: 2950-2956
Published online on: 30 January 2020

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Case Report

Complex karyotype with cryptic FUS gene rearrangement and deletion of NR3C1 and VPREB1 genes in childhood B‑cell acute lymphoblastic leukemia: A case report

Moneeb A.K. Othman, Marina Đurišić, Gordana Samardzija, Dragana Vujić, Nina Lakic, Zeljko Zecevic, Fawaz Al‑Shaheri, Rouben Aroutiounian, Joana B. Melo, Isabel M. Carreira, Britta Meyer, Thomas Liehr
Pages: 2957-2962
Published online on: 12 February 2020

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Article

Pristimerin inhibits the proliferation of HT1080 fibrosarcoma cells by inducing apoptosis

Daichi Hayashi, Toshiharu Shirai, Ryu Terauchi, Shinji Tsuchida, Naoki Mizoshiri, Yuki Mori, Yuji Arai, Osam Mazda, Toshikazu Kubo
Pages: 2963-2970
Published online on: 17 February 2020

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Article

Comprehensive circular RNA profiling reveals the regulatory role of circ_100242/miR-145 pathway in bladder cancer

Zhaowei Zhu, Fujiang Chang, Junxiao Liu, Jiange Wang, Xuepei Zhang
Pages: 2971-2978
Published online on: 10 February 2020

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Article

Development of a nine‑lncRNA signature as a novel prognostic marker of estrogen receptor‑negative breast cancer

Zhiwei Wang, Jie Wang, Lei Liu, Qi He, Min Wei
Pages: 2979-2988
Published online on: 13 February 2020

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Article

NOS1 expression promotes proliferation and invasion and enhances chemoresistance in ovarian cancer

Zhiwei Zou, Xiaoxuan Li, Yongliang Sun, Linlin Li, Qianbing Zhang, Lingqun Zhu, Zhuo Zhong, Meng Wang, Qianli Wang, Zhenjun Liu, Yifeng Wang, Yifang Ping, Kaitai Yao, Bingtao Hao, Qiuzhen Liu
Pages: 2989-2995
Published online on: 27 January 2020

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Article

Determination of the optimal detection time of circulating tumor cells for the postoperative monitoring of colorectal cancer

Tianchen Huang, Cheng Xu, Jianan Xiao, Qingbing Wang, Yanjun Wang, Yong Zhang, Dongxiao Bai, Fuyou Zhou, Xiaoyu Zhao
Pages: 2996-3002
Published online on: 12 February 2020

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Article

Methylation profiling in promoter sequences of ATM and CDKN2A (p14ARF/p16INK4a) genes in blood and cfDNA from women with impalpable breast lesions

Lucas Delmonico, Mauricio Augusto Silva Magalhães Costa, Romario José Gomes, Pâmella de Oliveira Vieira, Ana Beatriz Passos da Silva, Marcia V. Fournier, Luciano Rios Scherrer, Carolina Maria de Azevedo, Maria Helena Faria Ornellas, Gilda Alves
Pages: 3003-3010
Published online on: 10 February 2020

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Article

Serum melatonin is inversely associated with matrix metalloproteinase‑9 in oral squamous cell carcinoma

Adina Elena Stanciu, Adina Zamfir‑Chiru‑Anton, Marcel Marian Stanciu, Anca Pantea‑Stoian, Cornelia Nitipir, Dan Cristian Gheorghe
Pages: 3011-3020
Published online on: 13 February 2020

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Article

Potential synergistic effects of sorafenib and CP‑31398 for treating anaplastic thyroid cancer with p53 mutations

Jiin‑Torng Wu, Ching‑Ling Lin, Chi‑Jung Huang, Yu‑Che Cheng, Chih‑Cheng Chien, Yung‑Chuan Sung
Pages: 3021-3026
Published online on: 07 February 2020

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Article

Sasa quelpaertensis Nakai extract induces p53‑independent apoptosis via the elevation of nitric oxide production in human HCT116 colon cancer cells

Min Young Kim
Pages: 3027-3034
Published online on: 10 February 2020

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Correction Open Access

[Erratum] Peripheral primitive neuroectodermal tumors: A retrospective analysis of 89 cases and literature review

Liming Gao, Yingying Zhu, Xiaohua Shi, Zhiqiang Gao, Xingming Chen
Pages: 3035-3035
Published online on: 12 February 2020

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Review Open Access

Association of oral dysbiosis with oral cancer development (Review)

Giusy Rita Maria La Rosa, Giuseppe Gattuso, Eugenio Pedullà, Ernesto Rapisarda, Daria Nicolosi, Mario Salmeri
Pages: 3045-3058
Published online on: 03 March 2020

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Review Open Access

The roles of curcumin in regulating the tumor immunosuppressive microenvironment (Review)

Yizhi Wang, Jun Lu, Bolun Jiang, Junchao Guo
Pages: 3059-3070
Published online on: 03 March 2020

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Article Open Access

Long non‑coding RNA BRM promotes proliferation and invasion of papillary thyroid carcinoma by regulating the microRNA‑331‑3p/SLC25A1 axis

Shihong Liu, Deping Zhang, Li Chen, Shangfang Gao, Xiu Huang
Pages: 3071-3078
Published online on: 20 February 2020

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Article Open Access

microRNA‑144 inhibits cell proliferation and invasion by directly targeting TIGAR in esophageal carcinoma

Yushu Mu, Qifei Wang, Lei Tan, Lin Lin, Benhua Zhang
Pages: 3079-3088
Published online on: 24 February 2020

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Texture analysis of early cerebral tissue damage in magnetic resonance imaging of patients with lung cancer

Jiying Xu, Xiaoxiao Cui, Bomin Wang, Guangyu Wang, Meng Han, Ranran Li, Yana Qi, Jianjun Xiu, Qianlong Yang, Zhi Liu, Mingyong Han
Pages: 3089-3100
Published online on: 03 March 2020

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Article Open Access

Comprehensive genomic profile of cholangiocarcinomas in China

Weijun Tian, Weiyu Hu, Xiaoling Shi, Peng Liu, Xiang Ma, Wei Zhao, Linlin Qu, Shuirong Zhang, Weiwei Shi, Angen Liu, Jingyu Cao
Pages: 3101-3110
Published online on: 03 March 2020

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Article Open Access

Increased expression of the RNA‑binding motif protein 47 predicts poor prognosis in non‑small‑cell lung cancer

Ruilei Li, Heng Li, Chunlei Ge, Qiaofen Fu, Zhen Li, Yarong Jin, Qinghua Tan, Zhitao Zhu, Zhiwei Zhang, Suwei Dong, Gaofeng Li, Xin Song
Pages: 3111-3122
Published online on: 20 February 2020

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Integrated analysis of transcriptome profiling predicts potential lncRNA and circRNA targets in human nasopharyngeal carcinoma

Dong‑Ni Zhou, Chun‑Sheng Ye, Qing‑Qing Yang, Yan‑Fei Deng
Pages: 3123-3136
Published online on: 19 February 2020

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Article Open Access

Multidisciplinary treatment system for bone metastases for early diagnosis, treatment and prevention of malignant spinal cord compression

Eiji Nakata, Shinsuke Sugihara, Yoshifumi Sugawara, Ryuichi Nakahara, Takayuki Furumatsu, Tomonori Tetsunaga, Toshiyuki Kunisada, Kazuo Nakanishi, Yoshiteru Akezaki, Toshifumi Ozaki
Pages: 3137-3144
Published online on: 20 February 2020

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Article Open Access

CEP131 knockdown inhibits cell proliferation by inhibiting the ERK and AKT signaling pathways in non‑small cell lung cancer

Junying Wang, Xiaoping Yang, Shixin Han, Lizhi Zhang
Pages: 3145-3152
Published online on: 19 February 2020

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Article Open Access

Differential behavior of NF‑κB, IκBα and EGFR during the renal carcinogenic process in an experimental model in vivo

Telma Pariente‑Pérez, Francisco Aguilar‑Alonso, José Dolores Solano, Chabetty Vargas‑Olvera, Patricia Curiel‑Muñiz, Carmen Adriana Mendoza‑Rodríguez, Daniela Tenorio‑Hernández, María Elena Ibarra‑Rubio
Pages: 3153-3164
Published online on: 03 March 2020

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Article Open Access

Paeoniflorin inhibits cell viability and invasion of liver cancer cells via inhibition of Skp2

Hong Liu, Lili Zang, Jun Zhao, Zhaolin Wang, Lingyun Li
Pages: 3165-3172
Published online on: 03 March 2020

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Article Open Access

MicroRNA‑132‑3p regulates cell proliferation, apoptosis, migration and invasion of liver cancer by targeting Sox4

Jiansheng Huang, Dudan Lu, Tianxin Xiang, Xiaoping Wu, Shanfei Ge, Yue Wang, Jiaxin Wang, Na Cheng
Pages: 3173-3180
Published online on: 03 March 2020

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Article Open Access

High expression of FOXO3 is associated with poor prognosis in patients with hepatocellular carcinoma

Shu‑Shu Song, Jia‑Fu Ying, You‑Ni Zhang, Hong‑Ying Pan, Xiang‑Lei He, Zhi‑Ming Hu, Hui‑Ju Wang, Xiao‑Bing Dou, Xiao‑Zhou Mou
Pages: 3181-3188
Published online on: 03 March 2020

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Article Open Access

Enolase 1 differentially contributes to cell transformation in lung cancer but not in esophageal cancer

Jo‑Mei Maureen Chen, Shao‑Chih Chiu, Kun‑Chieh Chen, Yun‑Ru Jaoying Huang, Yu‑Ting Amber Liao, Chang‑Tze Ricky Yu
Pages: 3189-3196
Published online on: 03 March 2020

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Article Open Access

METTL3 serves an oncogenic role in human ovarian cancer cells partially via the AKT signaling pathway

Shumei Liang, Hongwei Guan, Xiaoyan Lin, Na Li, Feng Geng, Juan Li
Pages: 3197-3204
Published online on: 03 March 2020

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Article Open Access

APOBEC3B expression and its prognostic potential in breast cancer

Yan Mao, Meng Lv, Yuzi Zhang, Gang Nie, Jian Cui, Yongmei Wang, Yuanyuan Wang, Weihong Cao, Xiaoyi Liu, Xingang Wang, Haibo Wang
Pages: 3205-3214
Published online on: 03 March 2020

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Article Open Access

Advanced glycation end products induce proliferation, invasion and epithelial‑mesenchymal transition of human SW480 colon cancer cells through the PI3K/AKT signaling pathway

Huasheng Liang
Pages: 3215-3222
Published online on: 19 February 2020

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Article Open Access

Hematoporphyrin monomethyl ether‑mediated sonodynamic therapy induces A‑253 cell apoptosis

Yi Zhang, Liangjia Bi, Zheng Hu, Wenwu Cao, Deshu Zhuang
Pages: 3223-3228
Published online on: 21 February 2020

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Article Open Access

Methylated PTGER4 is better than CA125, CEA, Cyfra211 and NSE as a therapeutic response assessment marker in stage IV lung cancer

Yunxia Zhang, Jianfeng Huang, Qinzhou Zou, Jun Che, Kaihua Yang, Qiang Fan, Danqi Qian, Jia Wu, Erwen Bao, Lele Song, Fuzheng Zhang
Pages: 3229-3238
Published online on: 03 March 2020

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Article Open Access

miR‑320/ELF3 axis inhibits the progression of breast cancer via the PI3K/AKT pathway

Zhiqiang Zhang, Jinku Zhang, Jinmei Li, Huijuan Geng, Bingjuan Zhou, Bingxin Zhang, Hong Chen
Pages: 3239-3248
Published online on: 03 March 2020

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Article Open Access

Early risk warning system for distant metastasis of hepatitis B virus‑associated hepatocellular carcinoma with portal vein tumor thrombus

Mengge Li, Yalin Zhao, Xiaoli Liu, Shuan Zhang, Yuyong Jiang, Zhiyun Yang
Pages: 3249-3257
Published online on: 03 March 2020

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Article Open Access

Cell proliferation is induced in renal cell carcinoma through miR‑92a‑3p upregulation by targeting FBXW7

Rong Zeng, Jing Huang, Yujie Sun, Juan Luo
Pages: 3258-3268
Published online on: 03 March 2020

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Article Open Access

Autophagy suppresses resveratrol‑induced apoptosis in renal cell carcinoma 786‑O cells

Hongwei Yao, Min Fan, Xiaozhou He
Pages: 3269-3277
Published online on: 03 March 2020

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Article Open Access

Associations of sirtuins with clinicopathological variables and prognosis in human ovarian cancer

Qikuan He, Kai Chen, Ruifan Ye, Ninggao Dai, Pengyi Guo, Leixi Wang
Pages: 3278-3288
Published online on: 03 March 2020

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MicroRNA‑21 promotes cell metastasis in cervical cancer through modulating epithelial‑mesenchymal transition

Yaling Tang, Yan Zhao, Jing Ran, Yifeng Wang
Pages: 3289-3295
Published online on: 03 March 2020

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Profiles of m6A RNA methylation regulators for the prognosis of hepatocellular carcinoma

Wang Li, Qi‑Feng Chen, Tao Huang, Lujun Shen, Zi‑Lin Huang, Peihong Wu
Pages: 3296-3306
Published online on: 03 March 2020

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Upregulation of ASPM, BUB1B and SPDL1 in tumor tissues predicts poor survival in patients with pancreatic ductal adenocarcinoma

Xiong Tian, Na Wang
Pages: 3307-3315
Published online on: 19 February 2020

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Article Open Access

Comprehensive gene and pathway analysis of cervical cancer progression

Yuexiong Yi, Yan Fang, Kejia Wu, Yanyan Liu, Wei Zhang
Pages: 3316-3332
Published online on: 03 March 2020

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Article

Semaphorin‑4C is upregulated in epithelial ovarian cancer

Shaoyan Huang, Shan Han, Jianzhong Zhang, Zhaokun Zhong, Jianrong Wang
Pages: 3333-3338
Published online on: 03 March 2020

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Article

Downregulation of TMOD1 promotes cell motility and cell proliferation in cervical cancer cells

Fangjin Lu, Dandan Cui, Bin Mu, Lu Zhao, Ping Mu
Pages: 3339-3348
Published online on: 19 February 2020

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Article

RRM2 elicits the metastatic potential of breast cancer cells by regulating cell invasion, migration and VEGF expression via the PI3K/AKT signaling

Sujing Zhuang, Li Li, Yuwei Zang, Guangfeng Li, Feng Wang
Pages: 3349-3355
Published online on: 03 March 2020

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Correction Open Access

[Corrigendum] Self‑made thoracic needled suspending device with a snare: An excellent aid for uniportal video‑assisted thoracic lobectomy and segmentectomy for lung cancer

Shanlei Wang, Chuizheng Meng, Zhongmin Jiang, Diego Gonzalez-Rivas, Junfen Ruan, Wei Xu, Chuanping Liu, Lei Zhang, Guogang Gao, Ge Yu, Hezhi Teng, Jin Ju
Pages: 3356-3356
Published online on: 18 February 2020

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Correction Open Access

[Corrigendum] MicroRNA‑152 suppresses cisplatin resistance in A549 cells

Wenfei Zhao, Hongyun Li, Shanshan Yang, Di Guo, Jing Chen, Shaoyi Miao, Yi Xin, Miaomiao Liang
Pages: 3357-3357
Published online on: 28 February 2020

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Correction Open Access

[Corrigendum] P130cas is required for TGF‑β1‑mediated epithelial‑mesenchymal transition in lung cancer

Bo Deng, Qun‑You Tan, Ru‑Wen Wang, Yao‑Guang Jiang, Jing‑Hai Zhou, Wei Huang
Pages: 3358-3358
Published online on: 20 February 2020

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Correction Open Access

[Corrigendum] Loss of E‑cadherin promotes prostate cancer metastasis via upregulation of metastasis‑associated gene 1 expression

Liangsheng Fan, Hongyan Wang, Xi Xia, Yumei Rao, Xiangyi Ma, Ding Ma, Peng Wu, Gang Chen
Pages: 3359-3359
Published online on: 28 February 2020

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Journal Cover
April-2026 Volume 31 Issue 4

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Journal Metrics

Impact Factor: 2.2

CiteScore: 4.6

CiteScore Rank: Q2: #178/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.568

SCImago Journal Rank (SJR): 0.663

Case Report Open Access

Proliferative escalation and possible neuroendocrine carcinoma transformation in pulmonary metastases of a cervical neuroendocrine tumor: A case report

Nobuhito Hara, Rika Sasaki, Yoshiki Kojitani, Yumi Yoshii, Masahide Ota, Shunsuke Okazaki, Yuji Nitta, Tomoko Uchiyama, Akihiko Yoshizawa, Ryo Miyata, Masatsugu Hamaji, Hirotaka Kajihara, Masayuki Takeda
Article Number: 148
Published online on: 25 February 2026

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Gliosarcoma of the right cerebellar hemisphere and parahippocampal region: A case report and literature review

Fa Wu, Yulin Yang, Zaiqing Wang, Rui Jiang, Tingting Wu, Ting Yu, Peng Wang
Article Number: 147
Published online on: 25 February 2026

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Article Open Access

Preliminary evidence for the integration of CNAs, CN‑LOH and mutational profiles into the prognostic stratification of elderly patients with NPM1‑mutated acute myeloid leukemia

Li Gao, Chunxia Zhang, Ming Gong, Zhengyi Cao, Chundi Liu, Sijie Wang, Zhenling Li
Article Number: 146
Published online on: 25 February 2026

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Pro‑tumourigenic effects of DCAF13 on the progression of colorectal cancer

Wenqi Zhang, Rongrong Zhang, Mengxuan Jia, Shuting Lan, Fangyuan Liu, Qin Jin, Liya Su, Gang Liu
Article Number: 145
Published online on: 25 February 2026

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Review Open Access

Histone deacetylases: Function in tumor development and therapeutic prospects (Review)

Runling Lin, Yu Zhang, Hong Li, Fan Liang
Article Number: 144
Published online on: 24 February 2026

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Correction Open Access

[Corrigendum] Role of EphA2‑PI3K signaling in vasculogenic mimicry induced by cancer‑associated fibroblasts in gastric cancer cells

Hee Sung Kim, You Jin Won, Ju Hee Shim, Hyun Ji Kim, Byung Sik Kim, Hea Nam Hong
Article Number: 143
Published online on: 24 February 2026

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Case Report

Gastric cancer in pregnancy: A case report

Jianhua Niu, Yan Gao, Yu Sun, Huixia Yang
Article Number: 142
Published online on: 24 February 2026

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Correction Open Access

[Corrigendum] Potassium increases the antitumor effects of ascorbic acid in breast cancer cell lines in vitro

Giovanni Vanni Frajese, Monica Benvenuto, Massimo Fantini, Elena Ambrosin, Pamela Sacchetti, Laura Masuelli, Maria Gabriella Giganti, Andrea Modesti, Roberto Bei
Article Number: 141
Published online on: 17 February 2026

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Retraction Open Access

[Retracted] MicroRNA‑298 inhibits malignant phenotypes of epithelial ovarian cancer by regulating the expression of EZH2

Fenmei Zhou, Juan Chen, Hairong Wang
Article Number: 140
Published online on: 16 February 2026

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Case Report Open Access

Penile metastasis from prostate cancer with CDK12 mutation: A case report and literature review

Qi Xiang, Yanwu Wang, Bin Yao, Huiwen Tang, Qiang Dang
Article Number: 139
Published online on: 16 February 2026

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Case Report

Successful treatment with tepotinib followed by pembrolizumab in pulmonary pleomorphic carcinoma harbouring a MET exon 14 skipping mutation: A case report

Susumu Tanaka, Yu Saida, Yumi Ando, Jun Arinami, Ryo Yamazaki, Tomoya Wakabayashi, Hiroki Watanabe, Kohei Kushiro, Ryo Suzuki, Naohiro Yanagimura, Masashi Arita, Miyuki Sato, Tomohiro Tanaka, Koichiro Nozaki, Satoshi Watanabe, Shuhei Kondo, Hajime Umezu, Toshiaki Kikuchi
Article Number: 138
Published online on: 12 February 2026

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Article Open Access

METTL5‑mediated m6A modification of 18S rRNA drives oral squamous cell carcinoma progression by enhancing CCND3 translation

Lianlian Liu, Surui Sheng, Xin Zheng, Shuojin Huang, Lu Wang, Dalong Shu, Leile Tang, Qianting He
Article Number: 137
Published online on: 12 February 2026

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Correction Open Access

[Corrigendum] Mechanistic role of the ILK‑S100A4 axis in modulating invasion and EMT in salivary adenoid cystic carcinoma

Yang Yang, Jia-Xin Luo, Yuan-Yang Li, Ke-Hong Guo, Lin Ye, Dan Zhao
Article Number: 136
Published online on: 12 February 2026

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Review Open Access

STOML2 promotes hepatocellular carcinoma cell proliferation, invasion and migration by activating the PI3K/AKT signaling pathway (Review)

Mengyan Li, Jianli Chen
Article Number: 135
Published online on: 11 February 2026

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Article

Fatty acid‑induced lipid accumulation promotes radiosensitization in Huh7 hepatocellular carcinoma cells

Haruto Tanaka, Yasushi Mariya, Satoru Monzen
Article Number: 134
Published online on: 11 February 2026

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Lactylation‑based machine algorithm combined with multi‑omics analysis to predict prognosis in cervical cancer

Ruyue Wang, Li Ning, Xiu Li, Yating Xu, Yu Si, Hongting Zhao, Qingling Ren
Article Number: 133
Published online on: 11 February 2026

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Potential treatment benefits of a GLP‑1R antagonist in combination with immune checkpoint inhibitors in colorectal cancer

Zengqin Zhan, Chuncha Zhan, Lianqiao Li, Dan Lan, Guya Meng, Fan Chen
Article Number: 132
Published online on: 10 February 2026

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Article

Effect of the hsa‑microRNA 200c‑3p/ZEB1 loop in epithelial‑mesenchymal transition of ovarian cancer cells

Merve Senturk, Ece Gumusoglu‑Acar, Samet Topuz, Tuba Gunel
Article Number: 131
Published online on: 10 February 2026

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Article Open Access

Inhibition of IRE1α kinase increases ferroptosis resistance in triple‑negative breast cancer cells

Shuo Xu, Si-Qi Yang
Article Number: 130
Published online on: 10 February 2026

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Retraction Open Access

[Retracted] MicroRNA 217 inhibits cell proliferation and enhances chemosensitivity to doxorubicin in acute myeloid leukemia by targeting KRAS

Yi Xiao, Taoran Deng, Changliang Su, Zhen Shang
Article Number: 129
Published online on: 09 February 2026

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Case Report Open Access

Metastatic breast cancer in primary lung cancer with compound EGFR mutations: A case report

Tianyao Yang, Yifan Xu, Xi Lin, Guodong Chen, Fangfang Wang
Article Number: 128
Published online on: 09 February 2026

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Correction Open Access

[Corrigendum] miR‑185 enhances the inhibition of proliferation and migration induced by ionizing radiation in melanoma

Jinpeng He, Ning Tian, Yanli Yang, Liangliang Jin, Xiu Feng, Junrui Hua, Sulan Lin, Bing Wang, He Li, Jufang Wang
Article Number: 127
Published online on: 04 February 2026

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Review Open Access

Advances in targeting vasculogenic mimicry in malignant tumors using monomeric compounds from Traditional Chinese Medicine (Review)

Fang-Yuan Liu, Yu-Qian Fu, Dan-Ni Ding, Shao-Xuan Liu, Yu-Xin Zhao, Ying Shen, Jia Li
Article Number: 126
Published online on: 03 February 2026

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Article Open Access

Preoperative lymphocyte‑albumin‑monocyte index as an inflammation‑ and nutrition‑based predictor of overall survival in triple‑negative breast cancer: A retrospective cohort study

Boxiang Zhang, Kuan Wang, Maihemuti Aishanjiang, Fang Lan, Binlin Ma
Article Number: 125
Published online on: 02 February 2026

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Retraction Open Access

[Retracted] Epithelial cell adhesion molecule is overexpressed in hypopharyngeal carcinoma and suppresses the metastasis and proliferation of the disease when downregulated

Yakui Mu, Na Sa, Liang Yu, Sumei Lu, Haibo Wang, Wei Xu
Article Number: 124
Published online on: 02 February 2026

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Review Open Access

Combination of extracellular vesicles and organoids as a prospective model for cancer research (Review)

Jia Cao, Yanan Xu, Yuhan Gao, Xing Li, Libin Wang
Article Number: 123
Published online on: 30 January 2026

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Case Report Open Access

Malignant adenomyoepithelioma with HRAS G13R mutation: A case report

Hiroko Kuwabara, Reika Takeda, Yoshitaka Utsumi, Toshitaka Nagao, Kosei Kimura, Yoshinobu Hirose, Mitsuhiko Iwamoto
Article Number: 122
Published online on: 30 January 2026

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Case Report Open Access

Recurrent microsatellite instability‑high thymic carcinoma showing complete response to immune checkpoint inhibitor: A case report

Tomoki Nakagawa, Naohiro Aruga, Hajime Watanabe, Ryota Masuda, Shunsuke Yamada, Masayuki Iwazaki
Article Number: 121
Published online on: 29 January 2026

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Correction Open Access

[Corrigendum] Efficacy of transarterial chemoembolization‑hepatic arterial infusion chemotherapy combined with targeted therapy and immunotherapy in hepatocellular carcinoma with portal vein tumor thrombosis  

Xunbo Hou, Qiannan Xu, Linan Yin, Huiwen Wang, Juan Wu, Bowen Liu, Dongfeng He, Ruibao Liu
Article Number: 120
Published online on: 28 January 2026

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Journal Cover
May-2026 Volume 31 Issue 5

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Journal Metrics

Impact Factor: 2.2

CiteScore: 4.6

CiteScore Rank: Q2: #178/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.568

SCImago Journal Rank (SJR): 0.663

Retraction Open Access

[Retracted] MSK1 downregulation is associated with neuronal and astrocytic apoptosis following subarachnoid hemorrhage in rats

Bo Ning, Geng Guo, Hong Liu, Lei Ning, Bao-Liang Sun, Zhen Li, Shuo Wang, Zheng-Wen Lv, Cun-Dong Fan
Article Number: 167
Published online on: 09 March 2026

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Article Open Access

CANT1 as a novel prognostic biomarker in triple‑negative breast cancer

Doğan Bayram, Aysel Çolak, Şefi̇ka Karabulut, Sema Nur Özsan Çelebi̇, Emre Hafizoğlu, Duri̇ye Özer Türkay, Öznur Bal, Efnan Algin, Şebnem Yücel, Mehmet Ali̇ Nahi̇t Şendur, Burak Ci̇velek, Gökhan Uçar
Article Number: 166
Published online on: 09 March 2026

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RNA methyltransferase NSUN2 enhances vasculogenic mimicry and malignant progression of cervical cancer through upregulation of MMP‑9

Jun Luo, Guang Li, Mei Ye, Xiaoqing Xu, Mengwen Qi, Jian Huang, Kong Shan, Lili Qu, Hengchuan Shi
Article Number: 165
Published online on: 06 March 2026

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Long-term effects of using pegylated recombinant human granulocyte colony-stimulating factor following chemotherapy: A real-world study on patients with ovarian cancer

Weimin Zhang, Nenghuan Tang, Yiyue Wang, Tiantian Feng, Min Yong, Yuhua Zeng
Article Number: 164
Published online on: 06 March 2026

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Case Report Open Access

Primary clear‑cell carcinoma of the liver with gastric antrum metastasis: Integrated management with targeted therapy, immunotherapy and salvage surgery: A case report

Lianshan Zhan, Qianwei Li, Tian Tian, Long Wang
Article Number: 163
Published online on: 06 March 2026

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Case Report

Diagnostic and surgical challenges of a lymph node metastasis from occult gastric cancer mimicking a pancreatic head tumor: A case report

Takuya Ando, Yuki Hirose, Kazuyasu Takizawa, Jun Sakata, Hirosuke Ishikawa, Shun Abe, Yusuke Kawachi, Mae Nakano, Hiroshi Ichikawa, Yoshifumi Shimada, Toshifumi Wakai
Article Number: 162
Published online on: 05 March 2026

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Integrated analysis of therapeutic strategies and prognostic factors in advanced lung adenocarcinoma: Retrospective study with emphasis on gene assays, multimodality treatment approaches and predictive machine learning models

Shingchern You, Shiuan-Wen Chen, Irene Chen, Wei-Teing Chen
Article Number: 161
Published online on: 05 March 2026

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Review Open Access

Tumor‑muscle communication in cancer‑associated cachexia (Review)

Lily Berríos‑Contreras, Matías Meza‑Valenzuela, Nelson Brown, Claudio Valenzuela, Silvia Busquets, Francisco Javier López‑Soriano, Andrew Fg Quest, Rodrigo Moore‑Carrasco
Article Number: 160
Published online on: 05 March 2026

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Case Report Open Access

Pseudocirrhosis due to liver metastasis from lung squamous cell carcinoma: A case report

Qian Liu, Yufeng Lu, Dan Wang, Juan Yao, Ying Liu
Article Number: 159
Published online on: 04 March 2026

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Case Report

Malignant mesothelioma of the tunica vaginalis testis: A case report

Yuanchen Lu, Junjun Miu, Zhongru Fan, Zheng Zhi, Lei He, Junpeng Deng, Xianhua Shao, Jingqi Hua, Yichen Qian, Jianjun Xie
Article Number: 158
Published online on: 04 March 2026

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Case Report Open Access

Metachronous primary non‑small cell lung cancer and mucinous tubular and spindle cell carcinoma of the left kidney: A case report

Jin-Xia Zhao, Wei Zhu, Jie-Bin Pan, Peng-Fei Sun
Article Number: 157
Published online on: 04 March 2026

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Article Open Access

Telomere maintenance mechanisms are activated in ganglioneuroblastoma and ganglioneuroma

Motoki Sugawara, Masayuki Haruta, Miki Ohira, Jesmin Akter, Ritsuko Onuki, Ryuichi P. Sugino, Kiyohiro Ando, Atsuko Nakazawa, Hajime Okita, Tetsuya Takimoto, Tomoko Iehara, Tsugumichi Koshinaga, Shuichiro Uehara, Takehiko Kamijo
Article Number: 156
Published online on: 04 March 2026

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Article Open Access

Leucovorin enhances curcumin‑induced inhibition of cell viability and ferroptosis in colorectal cancer cells

Rui Meng, Qianqian Xu, Xue Wang, Hongwei Xu
Article Number: 155
Published online on: 04 March 2026

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Correction Open Access

[Corrigendum] Effects of 17‑allylamino‑17‑demethoxygeldanamycin on the induction of apoptosis and cell cycle arrest in HCT‑116  cells

Xuerong Zhao, Jianping Wang, Lijun Xiao, Qian Xu, Enhong Zhao, Xin Zheng, Huachuan Zheng, Shuang Zhao, Shi Ding
Article Number: 154
Published online on: 03 March 2026

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Review

Application of carbonic anhydrase IX‑targeted radiopharmaceuticals in the diagnosis and treatment of clear cell renal cell carcinoma (Review)

Min Wang, Yuqin Li, Wenbo Yang, Bin Liu
Article Number: 153
Published online on: 02 March 2026

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Review Open Access

Orchestrating organotropism: miRNA‑driven mechanisms of site‑specific metastasis in triple‑negative breast cancer (Review)

Rigude Bu, Liu Bo
Article Number: 151
Published online on: 02 March 2026

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Retraction Open Access

[Retracted] EGFR expression is associated with cytoplasmic staining of CXCR4 and predicts poor prognosis in triple‑negative breast carcinomas

Rong-Hui Li, Wen-He Huang, Jun-Dong Wu, Cai-Wen Du, Guo-Jun Zhang
Article Number: 150
Published online on: 02 March 2026

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Case Report Open Access

Adenoid cystic carcinoma of the vulva: A case report and literature review

Zhiying Ding, Guiqiu Liu, Chuanshan Zhang
Article Number: 149
Published online on: 26 February 2026

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