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Evaluation of kininogen 1, osteopontin and α‑1‑antitrypsin in plasma, bronchoalveolar lavage fluid and urine for lung squamous cell carcinoma diagnosis

  • Authors:
    • Weiwei Wang
    • Shanshan Wang
    • Man Zhang
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    Affiliations: Department of Pulmonary and Critical Care Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China, Department of Clinical Laboratory Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2785-2792
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    Published online on: February 6, 2020
       https://doi.org/10.3892/ol.2020.11376
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Abstract

Lung squamous cell carcinoma (LUSC) progression is accompanied by changes in protein levels that may be reflected in body fluids, such as plasma, bronchoalveolar lavage fluid (BALF) and urine. Certain proteins present in these biofluids can facilitate lung cancer diagnosis. Kininogen 1 (KNG1), osteopontin (OPN) and α‑1‑antitrypsin (AAT) are associated with tumorigenesis. The present study aimed to explore the combined monitoring of plasma, urine and BALF to gain insight into LUSC by monitoring the levels of the above three protein using ELISA. LUSC (n=31) and healthy controls with benign lung diseases (n=20) were enrolled in the study. KNG1 levels in plasma, BALF and urine were significantly higher in patients with LUSC patients than in controls (P<0.0001, P<0.0001 and P=0.0010, respectively). OPN was upregulated in the plasma and BALF of patients with LUSC relative to controls (P=0.0107 and P=0.0004, respectively), whereas its levels in the urine of healthy controls were significantly higher (P=0.0088). Patients with LUSC had higher AAT levels in plasma, BALF and urine compared with those of the controls (P=0.0022, P=0.0014 and P=0.0005, respectively). Receiver operating characteristic analysis showed an area under the curve (AUC) of 0.81 for KNG1 in plasma, 0.91 in BALF and 0.81 in urine. The AUC for OPN was 0.71 in plasma, 0.83 in BALF and 0.75 in urine. The AUC for AAT was 0.74 in plasma, 0.74 in BALF and 0.86 in urine. Immunohistochemical staining in 20 paired LUSC and adjacent normal tissues showed that KNG1, OPN and AAT levels were higher in LUSC tissues. Therefore, our results showed that KNG1, OPN and AAT in biofluids might be useful for the diagnosis of LUSC. These markers in urine and BALF may be better than in plasma for detecting LUSC.
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1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2019. CA Cancer J Clin. 69:7–34. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Osmani L, Askin F, Gabrielson E and Li QK: Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted therapy to immunotherapy. Semin Cancer Biol. 52:103–109. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Kikuchi T, Hassanein M, Amann JM, Liu Q, Slebos RJ, Rahman SM, Kaufman JM, Zhang X, Hoeksema MD, Harris BK, et al: In-depth proteomic analysis of nonsmall cell lung cancer to discover molecular targets and candidate biomarkers. Mol Cell Proteomics. 11:916–932. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Uribarri M, Hormaeche I, Zalacain R, Lopez-Vivanco G, Martinez A, Nagore D and Ruiz-Argüello MB: A new biomarker panel in bronchoalveolar lavage for an improved lung cancer diagnosis. J Thorac Oncol. 9:1504–1512. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Shimura T, Iwasaki H, Kitagawa M, Ebi M, Yamada T, Yamada T, Katano T, Nisie H, Okamoto Y, Ozeki K, et al: Urinary cysteine-rich protein 61 and trefoil factor 3 as diagnostic biomarkers for colorectal cancer. Transl Oncol. 12:539–544. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Ahn JM, Sung HJ, Yoon YH, Kim BG, Yang WS, Lee C, Park HM, Kim BJ, Kim BG, Lee SY, et al: Integrated glycoproteomics demonstrates fucosylated serum paraoxonase 1 alterations in small cell lung cancer. Mol Cell Proteomics. 13:30–48. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Abdullah-Soheimi SS, Lim BK, Hashim OH and Shuib AS: Patients with ovarian carcinoma excrete different altered levels of urine CD59, kininogen-1 and fragments of inter-alpha-trypsin inhibitor heavy chain H4 and albumin. Proteome Sci. 8:582010. View Article : Google Scholar : PubMed/NCBI

8 

Yu JS, Chen YT, Chiang WF, Hsiao YC, Chu LJ, See LC, Wu CS, Tu HT, Chen HW, Chen CC, et al: Saliva protein biomarkers to detect oral squamous cell carcinoma in a high-risk population in Taiwan. Proc Natl Acad Sci USA. 113:11549–11554. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Wang J, Wang X, Lin S, Chen C, Wang C, Ma Q and Jiang B: Identification of kininogen-1 as a serum biomarker for the early detection of advanced colorectal adenoma and colorectal cancer. PLoS One. 8:e705192013. View Article : Google Scholar : PubMed/NCBI

10 

Briones-Orta MA, Avendaño-Vázquez SE, Aparicio-Bautista DI, Coombes JD, Weber GF and Syn WK: Osteopontin splice variants and polymorphisms in cancer progression and prognosis. Biochim Biophys Acta Rev Cancer. 1868:93–108A. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Zhao H, Chen Q, Alam A, Cui J, Suen KC, Soo AP, Eguchi S, Gu J and Ma D: The role of osteopontin in the progression of solid organ tumour. Cell Death Dis. 9:3562018. View Article : Google Scholar : PubMed/NCBI

12 

Wang W, Wang S and Zhang M: Identification of urine biomarkers associated with lung adenocarcinoma. Oncotarget. 8:38517–38529. 2017.PubMed/NCBI

13 

Li Y, Miao L, Yu M, Shi M, Wang Y, Yang J, Xiao Y and Cai H: α1-antitrypsin promotes lung adenocarcinoma metastasis through upregulating fibronectin expression. Int J Oncol. 50:1955–1964. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Liang Y, Ma T, Thakur A, Yu H, Gao L, Shi P, Li X, Ren H, Jia L, Zhang S, et al: Differentially expressed glycosylated patterns of alpha-1-antitrypsin as serum biomarkers for the diagnosis of lung cancer. Glycobiology. 25:331–340. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Yu S, Meng Q, Hu H and Zhang M: Correlation of ANXA1 expression with drug resistance and relapse in bladder cancer. Int J Clin Exp Pathol. 7:5538–5548. 2014.PubMed/NCBI

16 

Pastor MD, Nogal A, Molina-Pinelo S, Quintanal-Villalonga Á, Meléndez R, Ferrer I, Romero-Romero B, De Miguel MJ, López-Campos JL, Corral J, et al: IL-11 and CCL-1: Novel protein diagnostic biomarkers of lung adenocarcinoma in bronchoalveolar lavage fluid (BALF). J Thorac Oncol. 11:2183–2192. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Doustjalali SR, Yusof R, Yip CH, Looi LM, Pillay B and Hashim OH: Aberrant expression of acute-phase reactant proteins in sera and breast lesions of patients with malignant and benign breast tumors. Electrophoresis. 25:2392–2401. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Abdul-Rahman PS, Lim BK and Hashim OH: Expression of high-abundance proteins in sera of patients with endometrial and cervical cancers: Analysis using 2-DE with silver staining and lectin detection methods. Electrophoresis. 28:1989–1996. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Mu AK, Lim BK, Hashim OH and Shuib AS: Identification of O-glycosylated proteins that are aberrantly excreted in the urine of patients with early stage ovarian cancer. International journal of molecular sciences. 14:7923–7931. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Sandim V, Pereira Dde A, Kalume DE, Oliveira-Carvalho AL, Ornellas AA, Soares MR, Alves G and Zingali RB: Proteomic analysis reveals differentially secreted proteins in the urine from patients with clear cell renal cell carcinoma. Urol Oncol. 34:5.e11–25. 2016. View Article : Google Scholar

21 

Xu J, Fang J, Cheng Z, Fan L, Hu W, Zhou F and Shen H: Overexpression of the Kininogen-1 inhibits proliferation and induces apoptosis of glioma cells. J Exp Clin Cancer Res. 37:1802018. View Article : Google Scholar : PubMed/NCBI

22 

Schrödter S, Braun M, Syring I, Klümper N, Deng M, Schmidt D, Perner S, Müller SC and Ellinger J: Identification of the dopamine transporter SLC6A3 as a biomarker for patients with renal cell carcinoma. Mol Cancer. 15:102016. View Article : Google Scholar : PubMed/NCBI

23 

Jiang W, Zhang L, Guo Q, Wang H, Ma M, Sun J and Chen C: Identification of the pathogenic biomarkers for hepatocellular carcinoma based on RNA-seq analyses. Pathol Oncol Res. 25:1207–1213. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Liu W, Liu B, Cai Q, Li J, Chen X and Zhu Z: Proteomic identification of serum biomarkers for gastric cancer using multi-dimensional liquid chromatography and 2D differential gel electrophoresis. Clinica Chimica Acta. 413:1098–1106. 2012. View Article : Google Scholar

25 

Quesada-Calvo F, Massot C, Bertrand V, Longuespée R, Blétard N, Somja J, Mazzucchelli G, Smargiasso N, Baiwir D, De Pauw-Gillet MC, et al: OLFM4, KNG1 and Sec24C identified by proteomics and immunohistochemistry as potential markers of early colorectal cancer stages. Clin Proteomics. 14:92017. View Article : Google Scholar : PubMed/NCBI

26 

Gao B, Yu T, Xue D, Sun B, Shao Q, Choudhry H, Marcus V, Ragoussis J, Zhang Y, Zhang W and Gao ZH: A multidimensional integration analysis reveals potential bridging targets in the process of colorectal cancer liver metastasis. PLoS One. 12:e01787602017. View Article : Google Scholar : PubMed/NCBI

27 

Navaneethan U, Lourdusamy V, Gk Venkatesh P, Willard B, Sanaka MR and Parsi MA: Bile proteomics for differentiation of malignant from benign biliary strictures: A pilot study. Gastroenterol Rep. 3:136–143. 2015. View Article : Google Scholar

28 

Li S, Yang R, Sun X, Miao S, Lu T, Wang Y, Wo Y and Jiao W: Identification of SPP1 as a promising biomarker to predict clinical outcome of lung adenocarcinoma individuals. Gene. 679:398–404. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Lin Q, Guo L, Lin G, Chen Z, Chen T, Lin J, Zhang B and Gu X: Clinical and prognostic significance of OPN and VEGF expression in patients with non-small-cell lung cancer. Cancer Epidemiol. 39:539–544. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Kothari AN, Arffa ML, Chang V, Blackwell RH, Syn WK, Zhang J, Mi Z and Kuo PC: Osteopontin-a master regulator of epithelial-mesenchymal transition. J Clin Med. 5:E392016. View Article : Google Scholar : PubMed/NCBI

31 

Zou C, Luo Q, Qin J, Shi Y, Yang L, Ju B and Song G: Osteopontin promotes mesenchymal stem cell migration and lessens cell stiffness via integrin β1, FAK, and ERK pathways. Cell Biochem Biophys. 65:455–462. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Marotta LL, Almendro V, Marusyk A, Shipitsin M, Schemme J, Walker SR, Bloushtain-Qimron N, Kim JJ, Choudhury SA, Maruyama R, et al: The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24− stem cell-like breast cancer cells in human tumors. J Clin Invest. 121:2723–2735. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Rouanne M, Adam J, Goubar A, Robin A, Ohana C, Louvet E, Cormier J, Mercier O, Dorfmüller P, Fattal S, et al: Osteopontin and thrombospondin-1 play opposite roles in promoting tumor aggressiveness of primary resected non-small cell lung cancer. BMC Cancer. 16:4832016. View Article : Google Scholar : PubMed/NCBI

34 

Ostheimer C, Schweyer F, Reese T, Bache M and Vordermark D: The relationship between tumor volume changes and serial plasma osteopontin detection during radical radiotherapy of non-small-cell lung cancer. Oncol Lett. 12:3449–3456. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Wang Y, Yang J, Liu H, Bi JR, Liu Y, Chen YY, Cao JY and Lu YJ: The association between osteopontin and survival in non-small-cell lung cancer patients: A meta-analysis of 13 cohorts. Onco Targets Ther. 8:3513–3521. 2015.PubMed/NCBI

36 

Mack PC, Redman MW, Chansky K, Williamson SK, Farneth NC, Lara PN Jr, Franklin WA, Le QT, Crowley JJ and Gandara DR; SWOG, : Lower osteopontin plasma levels are associated with superior outcomes in advanced non-small-cell lung cancer patients receiving platinum-based chemotherapy: SWOG Study S0003. J Clin Oncol. 26:4771–4776. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Chang SH, Cho KC, Yu KN, Hong SH, Park S, Lee AY, Kim S, Lee S, Kang JW, Chae C, et al: Alpha 1-antitrypsin activates lung cancer cell survival by acting on cap-dependent protein translation, vesicle-mediated transport, and metastasis. Oncotarget. 2016.

38 

Rodríguez-Piñeiro AM, Blanco-Prieto S, Sánchez-Otero N, Rodríguez-Berrocal FJ and de la Cadena MP: On the identification of biomarkers for non-small cell lung cancer in serum and pleural effusion. J Proteomics. 73:1511–1522. 2010. View Article : Google Scholar : PubMed/NCBI

39 

El-Akawi ZJ, Abu-Awad AM, Sharara AM and Khader Y: The importance of alpha-1 antitrypsin (alpha1-AT) and neopterin serum levels in the evaluation of non-small cell lung and prostate cancer patients. Neuro Endocrinol Lett. 31:113–116. 2010.PubMed/NCBI

40 

Chang YH, Lee SH, Liao IC, Huang SH, Cheng HC and Liao PC: Secretomic analysis identifies alpha-1 antitrypsin (A1AT) as a required protein in cancer cell migration, invasion, and pericellular fibronectin assembly for facilitating lung colonization of lung adenocarcinoma cells. Mol Cell Proteomics. 11:1320–1339. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Kataoka H, Uchino H, Iwamura T, Seiki M, Nabeshima K and Koono M: Enhanced tumor growth and invasiveness in vivo by a carboxyl-terminal fragment of alpha1-proteinase inhibitor generated by matrix metalloproteinases: A possible modulatory role in natural killer cytotoxicity. Am J Pathol. 154:457–468. 1999. View Article : Google Scholar : PubMed/NCBI

42 

Zelvyte I, Sjögren HO and Janciauskiene S: Effects of native and cleaved forms of alpha1-antitrypsin on ME 1477 tumor cell functional activity. Cancer Detect Prev. 26:256–265. 2002. View Article : Google Scholar : PubMed/NCBI

43 

Zelvyte I, Lindgren S and Janciauskiene S: Multiple effects of alpha1-antitrypsin on breast carcinoma MDA-MB 468 cell growth and invasiveness. Eur J Cancer Prev. 12:117–124. 2003. View Article : Google Scholar : PubMed/NCBI

44 

Yang P, Sun Z, Krowka MJ, Aubry MC, Bamlet WR, Wampfler JA, Thibodeau SN, Katzmann JA, Allen MS, Midthun DE, et al: Alpha1-antitrypsin deficiency carriers, tobacco smoke, chronic obstructive pulmonary disease, and lung cancer risk. Arch Intern Med. 168:1097–1103. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Higashiyama M, Doi O, Kodama K, Yokouchi H and Tateishi R: An evaluation of the prognostic significance of alpha-1-antitrypsin expression in adenocarcinomas of the lung: An immunohistochemical analysis. Br J Cancer. 65:300–302. 1992. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang W, Wang S and Zhang M: Evaluation of kininogen 1, osteopontin and α‑1‑antitrypsin in plasma, bronchoalveolar lavage fluid and urine for lung squamous cell carcinoma diagnosis. Oncol Lett 19: 2785-2792, 2020.
APA
Wang, W., Wang, S., & Zhang, M. (2020). Evaluation of kininogen 1, osteopontin and α‑1‑antitrypsin in plasma, bronchoalveolar lavage fluid and urine for lung squamous cell carcinoma diagnosis. Oncology Letters, 19, 2785-2792. https://doi.org/10.3892/ol.2020.11376
MLA
Wang, W., Wang, S., Zhang, M."Evaluation of kininogen 1, osteopontin and α‑1‑antitrypsin in plasma, bronchoalveolar lavage fluid and urine for lung squamous cell carcinoma diagnosis". Oncology Letters 19.4 (2020): 2785-2792.
Chicago
Wang, W., Wang, S., Zhang, M."Evaluation of kininogen 1, osteopontin and α‑1‑antitrypsin in plasma, bronchoalveolar lavage fluid and urine for lung squamous cell carcinoma diagnosis". Oncology Letters 19, no. 4 (2020): 2785-2792. https://doi.org/10.3892/ol.2020.11376
Copy and paste a formatted citation
x
Spandidos Publications style
Wang W, Wang S and Zhang M: Evaluation of kininogen 1, osteopontin and α‑1‑antitrypsin in plasma, bronchoalveolar lavage fluid and urine for lung squamous cell carcinoma diagnosis. Oncol Lett 19: 2785-2792, 2020.
APA
Wang, W., Wang, S., & Zhang, M. (2020). Evaluation of kininogen 1, osteopontin and α‑1‑antitrypsin in plasma, bronchoalveolar lavage fluid and urine for lung squamous cell carcinoma diagnosis. Oncology Letters, 19, 2785-2792. https://doi.org/10.3892/ol.2020.11376
MLA
Wang, W., Wang, S., Zhang, M."Evaluation of kininogen 1, osteopontin and α‑1‑antitrypsin in plasma, bronchoalveolar lavage fluid and urine for lung squamous cell carcinoma diagnosis". Oncology Letters 19.4 (2020): 2785-2792.
Chicago
Wang, W., Wang, S., Zhang, M."Evaluation of kininogen 1, osteopontin and α‑1‑antitrypsin in plasma, bronchoalveolar lavage fluid and urine for lung squamous cell carcinoma diagnosis". Oncology Letters 19, no. 4 (2020): 2785-2792. https://doi.org/10.3892/ol.2020.11376
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