|
1
|
Gatenby RA and Gillies RJ: Why do cancers
have high aerobic glycolysis? Nat Rev Cancer. 4:891–899. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Warburg O: On the origin of cancer cells.
Science. 123:309–314. 1956. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Koukourakis MI, Giatromanolaki A, Sivridis
E, Gatter KC and Harris AL; Tumour Angiogenesis Research Group, :
Lactate dehydrogenase 5 expression in operable colorectal cancer:
Strong association with survival and activated vascular endothelial
growth factor pathway-a report of the Tumour Angiogenesis Research
Group. J Clin Oncol. 24:4301–4308. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Rong Y, Wu W, Ni X, Kuang T, Jin D, Wang D
and Lou W: Lactate dehydrogenase A is overexpressed in pancreatic
cancer and promotes the growth of pancreatic cancer cells. Tumor
Biol. 34:1523–1530. 2013. View Article : Google Scholar
|
|
5
|
Yao F, Zhao T, Zhong C, Zhu J and Zhao H:
LDHA is necessary for the tumorigenicity of esophageal squamous
cell carcinoma. Tumor Biol. 34:25–31. 2013. View Article : Google Scholar
|
|
6
|
Hamabe A, Yamamoto H, Konno M, Uemura M,
Nishimura J, Hata T, Takemasa I, Mizushima T, Nishida N, Kawamoto
K, et al: Combined evaluation of hexokinase 2 and phosphorylated
pyruvate dehydrogenase-E1α in invasive front lesions of colorectal
tumors predicts cancer metabolism and patient prognosis. Cancer
Sci. 105:1100–1108. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Vander Heiden MG, Cantley LC and Thompson
CB: Understanding the Warburg effect: The metabolic requirements of
cell proliferation. Science. 324:1029–1033. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Daye D and Wellen KE: Metabolic
reprogramming in cancer: Unraveling the role of glutamine in
tumorigenesis. Semin Cell Dev Biol. 23:362–369. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Márquez J, de la Oliva AR, Matés JM,
Segura JA and Alonso FJ: Glutaminase: A multifaceted protein not
only involved in generating glutamate. Neurochem Int. 48:465–471.
2006. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Yang L, Venneti S and Nagrath D:
Glutaminolysis: A hallmark of cancer metabolism. Annu Rev Biomed
Eng. 19:163–194. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Huang F, Zhang Q, Ma H, Lv Q and Zhang T:
Expression of glutaminase is upregulated in colorectal cancer and
of clinical significance. Int J Clin Exp Pathol. 7:1093–1100.
2014.PubMed/NCBI
|
|
12
|
Curthoys NP and Watford M: Regulation of
glutaminase activity and glutamine metabolism. Annu Rev Nutr.
15:133–159. 1995. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Van Den Heuvel APJ, Jing J, Wooster RF and
Bachman KE: Analysis of glutamine dependency in non-small cell lung
cancer: GLS1 splice variant GAC is essential for cancer cell
growth. Cancer Biol Ther. 13:1185–1194. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Ueno H, Murphy J, Jass JR, Mochizuki H and
Talbot IC: Tumour budding as an index to estimate the potential of
aggressiveness in rectal cancer. Histopathol. 40:127–132. 2002.
View Article : Google Scholar
|
|
15
|
Prall F: Tumour budding in colorectal
carcinoma. Histopathol. 50:151–162. 2007. View Article : Google Scholar
|
|
16
|
Yang J and Weinberg RA:
Epithelial-mesenchymal transition: At the crossroads of development
and tumor metastasis. Dev Cell. 14:818–829. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Edge SB and Compton CC: The American joint
committee on cancer: The 7th edition of the AJCC cancer staging
manual and the future of TNM. Ann Surg Oncol. 17:1471–1474. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Hamilton SR, Bosman FT, Boffetta P, Ilyas
M, Morreau H, Nakamura SI, Quirke P, Riboli E and Sobin LH:
Carcinoma of the colon and rectum. WHO classification of tumours of
the digestive system. Bozman FT, Carneiro F, Hruban RH and Theise
ND: IARC Press; Lyon: pp. 134–146. 2010
|
|
19
|
Lugli A, Kirsch R, Ajioka Y, Bosman F,
Cathomas G, Dawson H, El Zimaity H, Fléjou JF, Hansen TP, Hartmann
A, et al: Recommendations for reporting tumor budding in colorectal
cancer based on the International Tumor Budding Consensus
Conference (ITBCC) 2016. Modern Pathol. 30:1299–1311. 2017.
View Article : Google Scholar
|
|
20
|
Girgis H, Masui O, White NM, Scorilas A,
Rotondo F, Seivwright A, Gabril M, Filter ER, Girgis AH, Bjarnason
GA, et al: Lactate dehydrogenase A is a potential prognostic marker
in clear cell renal cell carcinoma. Mol Cancer. 13:1012014.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Ondruschka C, Buhtz P, Motsch C, Freigang
B, Schneider-Stock R, Roessner A and Boltze C: Prognostic value of
MMP-2, −9 and TIMP-1,-2 immunoreactive protein at the invasive
front in advanced head and neck squamous cell carcinomas. Pathol
Res Pract. 198:509–515. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Chen TR, Drabkowski D, Hay RJ, Macy M and
Peterson W Jr: WiDr is a derivative of another colon adenocarcinoma
cell line, HT-29. Cancer Genet Cytogenet. 27:125–134. 1987.
View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Seltzer MJ, Bennett BD, Joshi AD, Gao P,
Thomas AG, Ferraris DV, Tsukamoto T, Rojas CJ, Slusher BS,
Rabinowitz JD, et al: Inhibition of glutaminase preferentially
slows growth of glioma cells with mutant IDH1. Cancer Res.
70:8981–8987. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Xiang Y, Stine ZE, Xia J, Lu Y, O'Connor
RS, Altman BJ, Hsieh AL, Gouw AM, Thomas AG, Gao P, et al: Targeted
inhibition of tumor-specific glutaminase diminishes cell-autonomous
tumorigenesis. J Clin Invest. 125:2293–2306. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Kawaguchi N, Tashiro K, Taniguchi K, Kawai
M, Tanaka K, Okuda J, Hayashi M and Uchiyama K: Nogo-B
(Reticulon-4B) functions as a negative regulator of the apoptotic
pathway through the interaction with c-FLIP in colorectal cancer
cells. Biochim Biophys Acta Mol Basis Dis. 1864:2600–2609. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Kagota S, Taniguchi K, Lee SW, Ito Y,
Kuranaga Y, Hashiguchi Y, Inomata Y, Imai Y, Tanaka R, Tashiro K,
et al: Analysis of extracellular vesicles in gastric juice from
gastric cancer patients. Int J Mol Sci. 20(pii): E9532019.
View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Cerami E, Gao J, Dogrusoz U, Gross BE,
Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et
al: The cBio cancer genomics portal: An open platform for exploring
multidimensional cancer genomics data. Cancer Discov. 2:401–404.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Gao J, Aksoy BA, Dogrusoz U, Dresdner G,
Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al:
Integrative analysis of complex cancer genomics and clinical
profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Cancer Genome Atlas Network: Comprehensive
molecular characterization of human colon and rectal cancer.
Nature. 487:330–337. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Giannakis M, Mu XJ, Shukla SA, Qian ZR,
Cohen O, Nishihara R, Bahl S, Cao Y, Amin-Mansour A, Yamauchi M, et
al: Genomic correlates of immune-cell infiltrates in colorectal
carcinoma. Cell Rep. 15:857–865. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Seshagiri S, Stawiski EW, Durinck S,
Modrusan Z, Storm EE, Conboy CB, Chaudhuri S, Guan Y, Janakiraman
V, Jaiswal BS, et al: Recurrent R-spondin fusions in colon cancer.
Nature. 488:660–664. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Brannon AR, Vakiani E, Sylvester BE, Scott
SN, McDermott G, Shah RH, Kania K, Viale A, Oschwald DM, Vacic V,
et al: Comparative sequencing analysis reveals high genomic
concordance between matched primary and metastatic colorectal
cancer lesions. Genome Biol. 15:4542014. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Yaeger R, Chatila WK, Lipsyc MD, Hechtman
JF, Cercek A, Sanchez-Vega F, Jayakumaran G, Middha S, Zehir A,
Donoghue MTA, et al: Clinical sequencing defines the genomic
landscape of metastatic colorectal cancer. Cancer Cell.
33:125–133.e3. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Guda K, Veigl ML, Varadan V, Nosrati A,
Ravi L, Lutterbaugh J, Beard L, Willson JK, Sedwick WD, Wang ZJ, et
al: Novel recurrently mutated genes in African American colon
cancers. Proc Natl Acad Sci USA. 112:1149–1154. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Vasaikar S, Huang C, Wang X, Petyuk VA,
Savage SR, Wen B, Dou Y, Zhang Y, Shi Z, Arshad OA, et al:
Proteogenomic analysis of human colon cancer reveals new
therapeutic opportunities. Cell. 177:1035–1049.e19. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Cairns RA, Harris IS and Mak TW:
Regulation of cancer cell metabolism. Nature Rev Cancer. 11:85–95.
2011. View Article : Google Scholar
|
|
37
|
Brabletz T, Hlubek F, Spaderna S,
Schmalhofer O, Hiendlmeyer E, Jung A and Kirchner T: Invasion and
metastasis in colorectal cancer: Epithelial-mesenchymal transition,
mesenchymal-epithelial transition, stem cells and beta-catenin.
Cells Tissues Organs. 179:56–65. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Reitzer LJ, Wice BM and Kennell D:
Evidence that glutamine, not sugar, is the major energy source for
cultured HeLa cells. J Biol Chem. 254:2669–2676. 1979.PubMed/NCBI
|
|
39
|
Owen OE, Kalhan SC and Hanson RW: The key
role of anaplerosis and cataplerosis for citric acid cycle
function. J Biol Chem. 277:30409–30412. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
DeBerardinis RJ, Lum JJ, Hatzivassiliou G
and Thompson CB: The biology of cancer: Metabolic reprogramming
fuels cell growth and proliferation. Cell Metab. 7:11–20. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Duka T, Collins Z, Anderson SM, Raghanti
MA, Ely JJ, Hof PR, Wildman DE, Goodman M, Grossman LI and Sherwood
CC: Divergent lactate dehydrogenase isoenzyme profile in cellular
compartments of primate forebrain structures. Mol Cell Neurosci.
82:137–142. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Langhammer S, Najjar M, Hess-Stumpp H and
Thierauch KH: LDH-A influences hypoxia-inducible factor 1α (HIF-1α)
and is critical for growth of HT29 colon carcinoma cells in vivo.
Targ Oncol. 6:155–162. 2011. View Article : Google Scholar
|
|
43
|
Kremer JC, Prudner BC, Lange SES, Bean GR,
Schultze MB, Brashears CB, Radyk MD, Redlich N, Tzeng SC, Kami K,
et al: Arginine deprivation inhibits the Warburg effect and
Upregulates glutamine anaplerosis and serine biosynthesis in
ASS1-deficient cancers. Cell Rep. 18:991–1004. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Valvona CJ, Fillmore HL, Nunn PB and
Pilkington GJ: The regulation and function of lactate dehydrogenase
A: Therapeutic potential in brain tumor. Brain Pathol. 26:3–17.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Losi L, Baisse B, Bouzourene H and
Benhattar J: Evolution of intratumoral genetic heterogeneity during
colorectal cancer progression. Carcinogenesis. 26:916–922. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Brattain MG, Fine WD, Khaled FM, Thompson
J and Brattain DE: Heterogeneity of malignant cells from a human
colonic carcinoma. Cancer Res. 41:1751–1756. 1981.PubMed/NCBI
|
|
47
|
Hu J, Locasale JW, Bielas JH, O'sullivan
J, Sheahan K, Cantley LC, Vander Heiden MG and Vitkup D:
Heterogeneity of tumor-induced gene expression changes in the human
metabolic network. Nat Biotechnol. 31:522–529. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Nassar A, Radhakrishnan A, Cabrero IA,
Cotsonis GA and Cohen C: Intratumoral heterogeneity of
immunohistochemical marker expression in breast carcinoma: A tissue
microarray-based study. Appl Immunohistochem Mol Morphol.
18:433–441. 2010.PubMed/NCBI
|
|
49
|
Böger C, Behrens HM and Röcken C: Ki67-An
unsuitable marker of gastric cancer prognosis unmasks intratumoral
heterogeneity. J Surg Oncol. 113:46–54. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Allott EH, Geradts J, Sun X, Cohen SM,
Zirpoli GR, Khoury T, Bshara W, Chen M, Sherman ME, Palmer JR, et
al: Intratumoral heterogeneity as a source of discordance in breast
cancer biomarker classification. Breast Cancer Res. 18:682016.
View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Jakobsen JN, Santoni-Rugiu E, Ravn J and
Sørensen JB: Intratumour variation of biomarker expression by
immunohistochemistry in resectable non-small cell lung cancer. Eur
J Cancer. 49:2494–2503. 2013. View Article : Google Scholar : PubMed/NCBI
|
