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Influence of combined epidural anesthesia on cognitive function, inflammation and stress response in elderly liver cancer patients undergoing surgery

  • Authors:
    • Yang Su
    • Yanan Pu
    • Zhengnan Zhao
    • Xianglong Yang
  • View Affiliations / Copyright

    Affiliations: Department of Emergency Anesthesia, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R. China, Department of Orthopedics, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R. China
    Copyright: © Su et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2733-2738
    |
    Published online on: February 14, 2020
       https://doi.org/10.3892/ol.2020.11395
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Abstract

Effects of combined epidural anesthesia on the cognitive function, inflammation and stress response in the elderly liver cancer patients undergoing surgery were explored. Elderly liver cancer patients (n=100) undergoing surgery in the Second Affiliated Hospital of Dalian Medical University from January 2015 to December 2018 were enrolled and randomly divided into observation group (n=50) and control group (n=50). In control group only conventional anesthesia was performed using 2 µg/kg fentanyl, 1.5 mg/kg propofol and 0.2 mg/kg atracurium, in addition to the procedures in the control group, combined epidural anesthesia was administered using 0.5% bupivacaine for 15 sec and maintained via 0.25% bupivacaine in the observation group. The anesthetic effect was observed and the arterial oxygen saturation (SaO2), heart rate (HR), mean arterial pressure (MAP) and mini‑mental state examination (MMSE) and cognitive function scores by cognitive abilities screening instrument (CASI) were evaluated in the patients, and their blood was drawn to detect the inflammatory factors interleukin (IL)‑6, IL‑1 and tumor necrosis factor‑α (TNF‑α), superoxide dismutase (SOD), malondialdehyde (MDA), catalase (CAT), norepinephrine and epinephrine. The observation group exhibited a better anesthetic effect and obviously smaller decreases in the SaO2 and MAP and increase in HR than the control group (P<0.05). The MMSE and CASI scores, and the content of IL‑1, IL‑6, TNF‑α, MDA, CAT, norepinephrine and epinephrine in the observation group was obviously lower than that in the control group (P<0.05), while the content of SOD was evidently higher than that in the control group (P<0.05). Overall postoperative conditions in the observation group was superior to the control group (P<0.05), with the incidence rate of cognitive disorder lower than that in the control group (P<0.05). Combined epidural anesthesia dramatically improves the postoperative conditions and cognitive function and relieve inflammatory and stress responses in the patients with a better anesthetic effect, thus holding promise for application.
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1 

Quaglia A, Tavilla A, Shack L, Brenner H, Janssen-Heijnen M, Allemani C, Colonna M, Grande E, Grosclaude P and Vercelli M; EUROCARE Working Group, : The cancer survival gap between elderly and middle-aged patients in Europe is widening. Eur J Cancer. 45:1006–1016. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Aapro MS, Köhne CH, Cohen HJ and Extermann M: Never too old? Age should not be a barrier to enrollment in cancer clinical trials. Oncologist. 10:198–204. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Yamamoto K, Takenaka K, Matsumata T, Shimada M, Itasaka H, Shirabe K and Sugimachi K: Right hepatic lobectomy in elderly patients with hepatocellular carcinoma. Hepatogastroenterology. 44:514–518. 1997.PubMed/NCBI

4 

Pawlik TM, Schulick RD and Choti MA: Expanding criteria for resectability of colorectal liver metastases. Oncologist. 13:51–64. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Zacharias T, Jaeck D, Oussoultzoglou E, Bachellier P and Weber JC: First and repeat resection of colorectal liver metastases in elderly patients. Ann Surg. 240:858–865. 2004. View Article : Google Scholar : PubMed/NCBI

6 

de Liguori Carino N, van Leeuwen BL, Ghaneh P, Wu A, Audisio RA and Poston GJ: Liver resection for colorectal liver metastases in older patients. Crit Rev Oncol Hematol. 67:273–278. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Simmonds PC, Primrose JN, Colquitt JL, Garden OJ, Poston GJ and Rees M: Surgical resection of hepatic metastases from colorectal cancer: A systematic review of published studies. Br J Cancer. 94:982–999. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Hanazaki K, Kajikawa S, Shimozawa N, Shimada K, Hiraguri M, Koide N, Adachi W and Amano J: Hepatic resection for hepatocellular carcinoma in the elderly. J Am Coll Surg. 192:38–46. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Xu XS, Chen W, Miao RC, Zhou YY, Wang ZX, Zhang LQ, Qu K, Pang Q, Wang RT and Liu C: Survival analysis of hepatocellular carcinoma: A comparison between young patients and aged patients. Chin Med J (Engl). 128:1793–1800. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Kondo K, Chijiiwa K, Funagayama M, Kai M, Otani K and Ohuchida J: Hepatic resection is justified for elderly patients with hepatocellular carcinoma. World J Surg. 32:2223–2229. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Monk TG, Weldon BC, Garvan CW, Dede DE, van der Aa MT, Heilman KM and Gravenstein JS: Predictors of cognitive dysfunction after major noncardiac surgery. Anesthesiology. 108:18–30. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Cibelli M, Fidalgo AR, Terrando N, Ma D, Monaco C, Feldmann M, Takata M, Lever IJ, Nanchahal J, Fanselow MS, et al: Role of interleukin-1beta in postoperative cognitive dysfunction. Ann Neurol. 68:360–368. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Rasmussen LS: Postoperative cognitive dysfunction: Incidence and prevention. Best Pract Res Clin Anaesthesiol. 20:315–330. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Fidalgo AR, Cibelli M, White JP, Nagy I, Maze M and Ma D: Systemic inflammation enhances surgery-induced cognitive dysfunction in mice. Neurosci Lett. 498:63–66. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Peng L, Xu L and Ouyang W: Role of peripheral inflammatory markers in postoperative cognitive dysfunction (POCD): A meta-analysis. PLoS One. 8:e796242013. View Article : Google Scholar : PubMed/NCBI

16 

Tsukamoto T, Chanthaphavong RS and Pape HC: Current theories on the pathophysiology of multiple organ failure after trauma. Injury. 41:21–26. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Sato H, Tanaka T, Kita T and Tanaka N: A quantitative study of lung dysfunction following haemorrhagic shock in rats. Int J Exp Pathol. 91:267–275. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Song J, Park J, Kim JY, Kim JD, Kang WS, Muhammad HB, Kwon MY, Kim SH, Yoon TG, Kim TY, et al: Effect of ulinastatin on perioperative organ function and systemic inflammatory reaction during cardiac surgery: A randomized double-blinded study. Korean J Anesthesiol. 64:334–340. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Portolani N, Baiocchi GL, Coniglio A, Tiberio GA, Prestini K, Gheza F, Benetti A and Maria Giulini S: Limited liver resection: A good indication for the treatment of hepatocellular carcinoma in elderly patients. Jpn J Clin Oncol. 41:1358–1365. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Di Benedetto F, Berretta M, D'Amico G, Montalti R, De Ruvo N, Cautero N, Guerrini GP, Ballarin R, Spaggiari M, Tarantino G, et al: Liver resection for colorectal metastases in older adults: A paired matched analysis. J Am Geriatr Soc. 59:2282–2290. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Mizuguchi T, Kawamoto M, Meguro M, Nakamura Y, Ota S, Hui TT and Hirata K: Prognosis and predictors of surgical complications in hepatocellular carcinoma patients with or without cirrhosis after hepatectomy. World J Surg. 37:1379–1387. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Mizuguchi T, Kawamoto M, Meguro M, Hui TT and Hirata K: Preoperative liver function assessments to estimate the prognosis and safety of liver resections. Surg Today. 44:1–10. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Nardo B, Serafini S, Ruggiero M, Grande R, Fugetto F, Zullo A, Novello M, Rizzuto A, Bonaiuto E, Vaccarisi S, et al: Liver resection for metastases from colorectal cancer in very elderly patients: New surgical horizons. Int J Surg. 33 (Suppl 1):S135–S141. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Hiraoka M, Miyagawa T, Kobayashi H, Takahashi T, Kishi H, Kobayashi H and Lee I: Successful introduction of modified dorsolumbar epidural anesthesia in a bovine referral center. J Vet Sci. 8:181–184. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Bedford PD: Adverse cerebral effects of anaesthesia on old people. Lancet. 269:259–263. 1955. View Article : Google Scholar : PubMed/NCBI

26 

Steinmetz J, Christensen KB, Lund T, Lohse N and Rasmussen LS; ISPOCD Group, : Long-term consequences of postoperative cognitive dysfunction. Anesthesiology. 110:548–555. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Chen J, Yan J and Han X: Dexmedetomidine may benefit cognitive function after laparoscopic cholecystectomy in elderly patients. Exp Ther Med. 5:489–494. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Soop M, Nygren J, Thorell A and Ljungqvist O: Stress-induced insulin resistance: Recent developments. Curr Opin Clin Nutr Metab Care. 10:181–186. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Desborough JP: The stress response to trauma and surgery. Br J Anaesth. 85:109–117. 2000. View Article : Google Scholar : PubMed/NCBI

30 

Brøchner AC and Toft P: Pathophysiology of the systemic inflammatory response after major accidental trauma. Scand J Trauma Resusc Emerg Med. 17:432009. View Article : Google Scholar : PubMed/NCBI

31 

Hadimioglu N, Ulugol H, Akbas H, Coskunfirat N, Ertug Z and Dinckan A: Combination of epidural anesthesia and general anesthesia attenuates stress response to renal transplantation surgery. Transplant Proc. 44:2949–2954. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Li Y, He R, Chen S and Qu Y: Effect of dexmedetomidine on early postoperative cognitive dysfunction and peri-operative inflammation in elderly patients undergoing laparoscopic cholecystectomy. Exp Ther Med. 10:1635–1642. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Su Y, Pu Y, Zhao Z and Yang X: Influence of combined epidural anesthesia on cognitive function, inflammation and stress response in elderly liver cancer patients undergoing surgery. Oncol Lett 19: 2733-2738, 2020.
APA
Su, Y., Pu, Y., Zhao, Z., & Yang, X. (2020). Influence of combined epidural anesthesia on cognitive function, inflammation and stress response in elderly liver cancer patients undergoing surgery. Oncology Letters, 19, 2733-2738. https://doi.org/10.3892/ol.2020.11395
MLA
Su, Y., Pu, Y., Zhao, Z., Yang, X."Influence of combined epidural anesthesia on cognitive function, inflammation and stress response in elderly liver cancer patients undergoing surgery". Oncology Letters 19.4 (2020): 2733-2738.
Chicago
Su, Y., Pu, Y., Zhao, Z., Yang, X."Influence of combined epidural anesthesia on cognitive function, inflammation and stress response in elderly liver cancer patients undergoing surgery". Oncology Letters 19, no. 4 (2020): 2733-2738. https://doi.org/10.3892/ol.2020.11395
Copy and paste a formatted citation
x
Spandidos Publications style
Su Y, Pu Y, Zhao Z and Yang X: Influence of combined epidural anesthesia on cognitive function, inflammation and stress response in elderly liver cancer patients undergoing surgery. Oncol Lett 19: 2733-2738, 2020.
APA
Su, Y., Pu, Y., Zhao, Z., & Yang, X. (2020). Influence of combined epidural anesthesia on cognitive function, inflammation and stress response in elderly liver cancer patients undergoing surgery. Oncology Letters, 19, 2733-2738. https://doi.org/10.3892/ol.2020.11395
MLA
Su, Y., Pu, Y., Zhao, Z., Yang, X."Influence of combined epidural anesthesia on cognitive function, inflammation and stress response in elderly liver cancer patients undergoing surgery". Oncology Letters 19.4 (2020): 2733-2738.
Chicago
Su, Y., Pu, Y., Zhao, Z., Yang, X."Influence of combined epidural anesthesia on cognitive function, inflammation and stress response in elderly liver cancer patients undergoing surgery". Oncology Letters 19, no. 4 (2020): 2733-2738. https://doi.org/10.3892/ol.2020.11395
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