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Article Open Access

lncRNA SNHG7 promotes tumorigenesis of nasopharyngeal carcinoma via epithelial‑to‑mesenchymal transition

Retraction in: /10.3892/ol.2020.11949
  • Authors:
    • Wenrui Xu
    • Xiaohan Sun
    • Chuanshan Zang
    • Yan Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology-Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2721-2726
    |
    Published online on: February 14, 2020
       https://doi.org/10.3892/ol.2020.11397
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Abstract

Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors. Studies have indicated that long noncoding RNAs (lncRNAs) function as important regulators in progression of tumorigenesis. In this study, lncRNA small nucleolar RNA host gene 7 (SNHG7) was selected to identify how it functioned in the development of NPC. Real‑time quantitative polymerase chain reaction (RT‑qPCR) was performed to detect SNHG7 expression in paired NPC patient tissue samples and cell lines. The role of SNHG7 in the metastasis of NPC was detected through scratch wound assay and Transwell assay. RT‑qPCR and western blot assay were used to discover the function of SNHG7 in epithelial‑to‑mesenchymal transition (EMT) process. Tumor metastasis assay was also performed in vivo. In this study, RT‑qPCR results showed that SNHG7 expression in NPC samples was remarkably higher when compared with that in adjacent ones. Cell invasion and cell migration of NPC were inhibited due to silence of SNHG7 and were promoted due to overexpression of SNHG7. Moreover, results of further experiments revealed that the EMT‑related proteins were regulated via knockdown or overexpression of SNHG7 in NPC. Furthermore, tumor metastasis of NPC was inhibited via knockdown of SNHG7 and was enhanced via overexpression of SNHG7 in nude mice. These results indicate that SNHG7 enhances NPC cell invasion and cell migration by eliciting the EMT process.
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Copy and paste a formatted citation
Spandidos Publications style
Xu W, Sun X, Zang C and Jiang Y: lncRNA SNHG7 promotes tumorigenesis of nasopharyngeal carcinoma via epithelial‑to‑mesenchymal transition Retraction in /10.3892/ol.2020.11949. Oncol Lett 19: 2721-2726, 2020.
APA
Xu, W., Sun, X., Zang, C., & Jiang, Y. (2020). lncRNA SNHG7 promotes tumorigenesis of nasopharyngeal carcinoma via epithelial‑to‑mesenchymal transition Retraction in /10.3892/ol.2020.11949. Oncology Letters, 19, 2721-2726. https://doi.org/10.3892/ol.2020.11397
MLA
Xu, W., Sun, X., Zang, C., Jiang, Y."lncRNA SNHG7 promotes tumorigenesis of nasopharyngeal carcinoma via epithelial‑to‑mesenchymal transition Retraction in /10.3892/ol.2020.11949". Oncology Letters 19.4 (2020): 2721-2726.
Chicago
Xu, W., Sun, X., Zang, C., Jiang, Y."lncRNA SNHG7 promotes tumorigenesis of nasopharyngeal carcinoma via epithelial‑to‑mesenchymal transition Retraction in /10.3892/ol.2020.11949". Oncology Letters 19, no. 4 (2020): 2721-2726. https://doi.org/10.3892/ol.2020.11397
Copy and paste a formatted citation
x
Spandidos Publications style
Xu W, Sun X, Zang C and Jiang Y: lncRNA SNHG7 promotes tumorigenesis of nasopharyngeal carcinoma via epithelial‑to‑mesenchymal transition Retraction in /10.3892/ol.2020.11949. Oncol Lett 19: 2721-2726, 2020.
APA
Xu, W., Sun, X., Zang, C., & Jiang, Y. (2020). lncRNA SNHG7 promotes tumorigenesis of nasopharyngeal carcinoma via epithelial‑to‑mesenchymal transition Retraction in /10.3892/ol.2020.11949. Oncology Letters, 19, 2721-2726. https://doi.org/10.3892/ol.2020.11397
MLA
Xu, W., Sun, X., Zang, C., Jiang, Y."lncRNA SNHG7 promotes tumorigenesis of nasopharyngeal carcinoma via epithelial‑to‑mesenchymal transition Retraction in /10.3892/ol.2020.11949". Oncology Letters 19.4 (2020): 2721-2726.
Chicago
Xu, W., Sun, X., Zang, C., Jiang, Y."lncRNA SNHG7 promotes tumorigenesis of nasopharyngeal carcinoma via epithelial‑to‑mesenchymal transition Retraction in /10.3892/ol.2020.11949". Oncology Letters 19, no. 4 (2020): 2721-2726. https://doi.org/10.3892/ol.2020.11397
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