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Article Open Access

Heavy metals interfere with plasma metabolites, including lipids and amino acids, in patients with breast cancer

  • Authors:
    • Ling Li
    • Meihua Zhang
    • Yuhao Men
    • Wei Wang
    • Weidong Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Affiliated Tengzhou Central People's Hospital of Jining Medical University, Tengzhou, Shandong 277599, P.R. China, Medical Image Center, Affiliated Tengzhou Central People's Hospital of Jining Medical University, Tengzhou, Shandong 277599, P.R. China, College of Animal Sciences and Technology, Qingdao Agricultural University, Qingdao, Shandong 266109, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2925-2933
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    Published online on: February 17, 2020
       https://doi.org/10.3892/ol.2020.11402
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Abstract

The aim of the present study was to examine the association between plasma heavy metals and the metabolome in patients with breast cancer (BC), and the association with cancer development. Nuclear magnetic resonance was used to determine the metabolites involved and an inductively coupled plasma mass spectrometry system was used to quantify the heavy metals in the plasma samples. It was indicated that cadmium was significantly higher in the plasma of patients with BC compared with that in the control population (~15‑fold increase). Chromium, arsenic and lead were also elevated in the plasma of patients with BC by ~3.24, 2.14 and 1.52 fold, respectively. A number of small molecules, including amino acids and salts, were altered in the plasma of patients with BC compared with the control population. Another notable finding in this investigation was that plasma lipid levels were elevated in patients with BC compared with those in the control population. The findings of the present study suggest that exposure to heavy metals, including cadmium, arsenic, chromium and lead, may influence blood lipid levels and other small molecule metabolites, which in turn may be involved in BC development. Further studies surrounding urinary heavy metals and the metabolome are required to further determine the impact of metals on metabolism and on BC development.
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1 

Lécuyer L, Victor Bala A, Deschasaux M, Bouchemal N, Nawfal Triba M, Vasson MP, Rossary A, Demidem A, Galan P, Hercberg S, et al: NMR metabolomics signatures reveal predictive plasma metabolites associated with long-term risk of developing breast cancer. Int J Epidemiol. 47:484–494. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Ferlay J, Soerjomataram I and Ervik M: GLOBOCAN 2012 v1.0, cancer incidence and mortality worldwide: IARC CancerBase No. 11. Lyon, France: International Agency for Research on Cancer; 2013

3 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2012. CA Cancer J Clin. 62:10–29. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Rzymski P, Tomczyk K, Rzymski P, Poniedziałek B, Opala T and Wilczak M: Impact of heavy metals on the female reproductive system. Ann Agric Environ Med. 22:259–264. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Prüss-Üstün A and Corvalán C: Preventing disease through healthy environments. Towards an estimate of the environmental burden of disease. World Health Organization; France: 2006

6 

Howell A, Anderson AS, Clarke RB, Duffy SW, Evans DG, Garcia-Closas M, Gescher AJ, Key TJ, Saxton JM and Harvie MN: Risk determination and prevention of breast cancer. Breast Cancer Res. 16:4462014. View Article : Google Scholar : PubMed/NCBI

7 

Claudino WM, Quattronem A, Biganzoli L, Pestrin M, Bertini I and Di Leo A: Metabolomics: Available results, current research projects in breast cancer, and future applications. J Clin Oncol. 25:2840–2846. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Griffin JL: The Cinderella story of metabolic profiling: Does metabolomics get to go to the functional genomics ball? Philos Trans R Soc London B Biol Sci. 361:147–161. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Kruk J, Doskocz M, Jodłowska E, Zacharzewska A, Łakomiec J, Czaja K and Kujawski J: NMR techniques in metabolomic studies: A quick overview on examples of utilization. Appl Magn Reson. 48:1–21. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Denkert C, Budczies J, Kind T, Weichert W, Tablack P, Sehouli J, Niesporek S, Könsgen D, Dietel M and Fiehn O: Mass spectrometry-based metabolic profiling reveals different metabolite patterns in invasive ovarian carcinomas and ovarian borderline tumors. Cancer Res. 66:10795–10804. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Bathen TF, Sitter B, Sjøbakk TE, Tessem MB and Gribbestad IS: Magnetic resonance metabolomics of intact tissue: A biotechnological tool in cancer diagnostics and treatment evaluation. Cancer Res. 70:6692–6696. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Brennan L: NMR-based metabolomics: From sample preparation to applications in nutrition research. Prog Nucl Magn Reson Spectrosc. 83:42–49. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Dunn WB, Goodacre R, Neyses L and Mamas M: Integration of metabolomics in heart disease and diabetes research: Current achievements and future outlook. Bioanalysis. 3:2205–2222. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Suhre K, Shin SY, Petersen AK, Mohney RP, Meredith D, Wägele B, Altmaier E; CARDIoGRAM, ; Deloukas P, Erdmann J, et al: Human metabolic individuality in biomedical and pharmaceutical research. Nature. 477:54–60. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Bictash M, Ebbels TM, Chan Q, Loo RL, Yap IK, Brown IJ, de Iorio M, Daviglus ML, Holmes E, Stamler J, et al: Opening up the ‘Black Box’: Metabolic phenotyping and metabolome-wide association studies in epidemiology. J Clin Epidemiol. 63:970–979. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Holmes E, Loo RL, Stamler J, Bictash M, Yap IK, Chan Q, Ebbels T, De Iorio M, Brown IJ, Veselkov KA, et al: Human metabolic phenotype diversity and its association with diet and blood pressure. Nature. 453:396–400. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Norvig P, Relman DA, Goldstein DB, et al: 2020 visions. Nature. 463:26–32. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Byrne C, Divekar SD, Storchan GB, Parodi DA and Martin MB: Metals and breast cancer. J Mammary Gland Biol Neoplasia. 18:63–73. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Krizek M, Senft V and Motan J: Copper and the human body. Cas Lek Cesk. 136:698–701. 1997.(In Czech). PubMed/NCBI

20 

Chan S, Gerson B and Subramaniam S: The role of copper, molybdenum, selenium, and zinc in nutrition and health. Clin Lab Med. 18:673–685. 1998. View Article : Google Scholar : PubMed/NCBI

21 

Christianson DW and Cox JD: Catalysis by metal-activated hydroxide in zinc and manganese metalloenzymes. Annu Rev Biochem. 68:33–57. 1999. View Article : Google Scholar : PubMed/NCBI

22 

Waalkes MP, Fox DA, States JC, Patierno SR and McCabe MJ Jr: Metals and disorders of cell accumulation: Modulation of apoptosis and cell proliferation. Toxicol Sci. 56:255–261. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Järup L: Hazards of heavy metals contamination. Br Med Bull. 68:167–182. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Rzymski P, Niedzielski P, Poniedziałek B and Klimaszyk P: Bioaccumulation of selected metals in bivalves (Unionidae) and Phragmites australis inhabiting a municipal water reservoir. Environ Monit Assess. 186:3199–3212. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Hayes RB: The carcinogenicity of metals in humans. Cancer Causes Control. 8:371–385. 1997. View Article : Google Scholar : PubMed/NCBI

26 

Some metals and metallic compounds. IARC Monogr Eval Carcinog Risk Chem Hum. 23:1–420. 1980.PubMed/NCBI

27 

Gartell MJ, Craun JC, Podrebarae DS and Gunderson EL: Pesticides, selected elements and other chemicals in infant and toddler total diet samples. October 1980-March 1982. J Assoc Off Anal Chem. 69:123–145. 1986.PubMed/NCBI

28 

Gartell MJ, Craun JC, Podrebarae DS and Gunderson EL: Pesticides, selected elements and other chemicals in adult total diet samples, October 1980-March 1982. J Assoc Off Anal Chem. 69:146–159. 1986.PubMed/NCBI

29 

Szyczewski P, Siepak P, Niedzielski P and Sobczyński T: Research on heavy metals in Poland. Pol J Environ Stud. 8:755–768. 2009.

30 

Antila E, Mussalo-Rauhamaa H, Kantola M, Atroshi F and Westermarck T: Association of cadmium with human breast cancer. Sci Total Environ. 186:251–256. 1996. View Article : Google Scholar : PubMed/NCBI

31 

Romaniuk A, Lyndin M, Moskalenko R, Kuzenko Y, Gladchenko O and Lyndina Y: Pathogenetic mechanisms of heavy metals effect on proapoptotic and proliferative potential of breast cancer. Interv Med Appl Sci. 7:63–67. 2015.PubMed/NCBI

32 

Zhang W, Zhao Y, Li F, Li L, Feng Y, Min L, Ma D, Yu S, Liu J, Zhang H, et al: Zinc oxide nanoparticle caused plasma metabolomic perturbations correlate with hepatic steatosis. Front Pharmacol. 9:572018. View Article : Google Scholar : PubMed/NCBI

33 

Soininen P, Kangas AJ, Würtz P, Tukiainen T, Tynkkynen T, Laatikainen R, Järvelin MR, Kähönen M, Lehtimäki T, Viikari J, et al: High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism. Analyst. 134:1781–1785. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Mäkinen VP, Soininen P, Forsblom C, Parkkonen M, Ingman P, Kaski K, Groop PH; FinnDiane Study Group, ; Ala-Korpela M: 1H NMR metabonomics approach to the disease continuum of diabetic complications and premature death. Mol Syst Biol. 4:1672008. View Article : Google Scholar : PubMed/NCBI

35 

Yan G, Huang Y, Bu Q, Lv L, Deng P, Zhou J, Wang Y, Yang Y, Liu Q, Cen X and Zhao Y: Zinc oxide nanoparticles cause nephrotoxicity and kidney metabolism alterations in rats. J Environ Sci Health A Tox Hazard Subst Environ Eng. 47:577–588. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Wan Q, He Q, Deng X, Hao F, Tang H and Wang Y: Systemic metabolic responses of broiler chickens and piglets to acute T-2 toxin intravenous exposure. J Agric Food Chem. 64:714–723. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Zhao Y, Feng YN, Li L, Zhang HF, Zhang YN, Zhang PF, Liu XQ, Zhang WD, Huang TT, Zhao L, et al: Tissue-specific regulation of the contents and correlations of mineral elements in hens by zinc oxide nanoparticles. Biol Trace Elem Res. 177:353–366. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Men Y, Li L, Zhang F, Kong X, Zhang W, Hao C and Wang G: Evaluation of heavy metals and metabolites in the urine of patients with breast cancer. Oncol Lett. 19:1331–1337. 2020.PubMed/NCBI

39 

Zimeri AM, Robb SW, Hassan SM, Hire RR and Davis MB: Assessing heavy metal and PCB exposure from tap water by measuring levels in plasma from sporadic breast cancer patients, a pilot study. Int J Environ Res Public Health. 12:15683–15691. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Wood RY and Della-Monica NR: Psychosocial factors influencing breast cancer risk appraisal among older women. Qual Health Res. 21:783–795. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Salhab M, Bismohun S and Mokbel K: Risk-reducing strategies for women carrying BRCA1/2 mutations with a focus on prophylactic surgery. BMC Womens Health. 10:282010. View Article : Google Scholar : PubMed/NCBI

42 

Jevtic M, Velicki R, Popovic M, Cemerlic-Adjic N, Babovic SS and Velicki L: Dietary influence on breast cancer. J BUON. 15:455–461. 2010.PubMed/NCBI

43 

Ebrahim AM, Eltayeb MA, Shaat MK, Mohmed NM, Eltayeb EA and Ahmed AY: Study of selected trace elements in cancerous and non-cancerous human breast tissues from Sudanese subjects using instrumental neutron activation analysis. Sci Total Environ. 383:52–58. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Florea AM and Büsselberg D: Metals and breast cancer: Risk factors or healing agents? J Toxicol. 2011:1596192011. View Article : Google Scholar : PubMed/NCBI

45 

Ilychova SA and Zaridze DG: Cancer mortality among female and male workers occupationally exposed to inorganic lead in the printing industry. Occup Environ Med. 69:87–92. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Qu W, Tokar EJ, Kim AJ, Bell MW and Waalkes MP: Chronic cadmium exposure in vitro causes acquisition of multiple tumor cell characteristics in human pancreatic epithelial cells. Environ Health Perspect. 120:1265–1271. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Cheung MR: Blood lead concentration correlates with all cause, all cancer and lung cancer mortality in adults: A population based study. Asian Pac J Cancer Prev. 14:3105–3108. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Person RJ, Tokar EJ, Xu Y, Orihuela R, Ngalame NN and Waalkes MP: Chronic cadmium exposure in vitro induces cancer cell characteristics in human lung cells. Toxicol Appl Pharmacol. 273:281–288. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Wadhwa SK, Kazi TG, Afridi HI, Talpur FN and Naeemullah: Interaction between carcinogenic and anti-carcinogenic trace elements in the scalp hair samples of different types of Pakistani female cancer patients. Clin Chim Acta. 439:178–184. 2015. View Article : Google Scholar : PubMed/NCBI

50 

Núñez O, Fernández-Navarro P, Martín-Méndez I, Bel-Lan A, Locutura JF and López-Abente G: Arsenic and chromium topsoil levels and cancer mortality in Spain. Environ Sci Pollut Res Int. 23:17664–17675. 2016. View Article : Google Scholar : PubMed/NCBI

51 

Welling R, Beaumont JJ, Petersen SJ, Alexeeff GV and Steinmaus C: Chromium VI and stomach cancer: A meta-analysis of the current epidemiological evidence. Occup Environ Med. 72:151–159. 2015. View Article : Google Scholar : PubMed/NCBI

52 

Peralta-Videa JR, Lopez ML, Narayan M, Saupe G and Gardea-Torresdey J: The biochemistry of environmental heavy metal uptake by plants: Implications for the food chain. Int J Biochem Cell Biol. 41:1665–1677. 2009. View Article : Google Scholar : PubMed/NCBI

53 

ATSDR: Toxicological profile for arsenic. Agency for Toxic Substances and Disease Registry (ATSDR). U.S. Department of Health and Human Services; Atlanta: 2007

54 

IARC Arsenic, metals, fibres and dusts. IARC monographs on the evaluation of carcinogenic risks to humans. 100c. International Agency for Research on Cancer; Lyon: 2012

55 

Hasija K and Bagga HK: Alterations of serum cholesterol and serum lipoprotein in breast cancer of women. Indian J Clin Biochem. 20:61–66. 2005. View Article : Google Scholar : PubMed/NCBI

56 

Raza U, Asif MR, Rehman AB and Sheikh A: Hyperlipidemia and hyper glycaemia in breast cancer patients is related to disease stage. Pak J Med Sci. 34:209–214. 2018. View Article : Google Scholar : PubMed/NCBI

57 

Laisupasain P, Thompat W, Sukarayodhin S, Somprom A and Sudjaroen Y: Comparison of Serum lipid profiles between normal control and breast cancer patients. J Lab Physician. 5:38–41. 2013. View Article : Google Scholar

58 

Alexopoulos CG, Blatsios B and Avgerinos A: Serum lipids and lipoprotein disorders in cancer patients. Cancer. 60:3065–3070. 1987. View Article : Google Scholar : PubMed/NCBI

59 

Santos-Gallego CG and Jialal I: Cadmium and atherosclerosis: Heavy metal or singing the blues? Atherosclerosis. 249:230–232. 2016. View Article : Google Scholar : PubMed/NCBI

60 

Zhou Z, Lu YH, Pi HF, Gao P, Li M, Zhang L, Pei LP, Mei X, Liu L, Zhao Q, et al: Cadmium exposure is associated with the prevalence of dyslipidemia. Cell Physiol Biochem. 40:633–643. 2016. View Article : Google Scholar : PubMed/NCBI

61 

Ledda C, Iavicoli I, Bracci M, Avola R, Senia P, Santarelli L, Pomara C and Rapisarda V: Serum lipid, lipoprotein and apolipoprotein profiles in workers exposed to low arsenic levels: Lipid profiles and occupational arsenic exposure. Toxicol Lett. 282:49–56. 2018. View Article : Google Scholar : PubMed/NCBI

62 

Waghe P, Sarkar SN, Sarath TS, Kandasamy K, Choudhury S, Gupta P, Harikumar S and Mishra SK: Subchronic arsenic exposure through drinking water alters lipid profile and electrolyte status in rats. Biol Trace Elem Res. 176:350–354. 2017. View Article : Google Scholar : PubMed/NCBI

63 

Cha YJ, Kim ES and Koo JS: Amino acid transporters and glutamine metabolism in breast cancer. Int J Mol Sci. 19:E9072018. View Article : Google Scholar : PubMed/NCBI

64 

His M, Viallon V, Dossus L, Gicquiau A, Achaintre D, Scalbert A, Ferrari P, Romieu I, Onland-Moret NC, Weiderpass E, et al: Prospective analysis of circulating metabolites and breast cancer in EPIC. BMC Med. 17:1782019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li L, Zhang M, Men Y, Wang W and Zhang W: Heavy metals interfere with plasma metabolites, including lipids and amino acids, in patients with breast cancer. Oncol Lett 19: 2925-2933, 2020.
APA
Li, L., Zhang, M., Men, Y., Wang, W., & Zhang, W. (2020). Heavy metals interfere with plasma metabolites, including lipids and amino acids, in patients with breast cancer. Oncology Letters, 19, 2925-2933. https://doi.org/10.3892/ol.2020.11402
MLA
Li, L., Zhang, M., Men, Y., Wang, W., Zhang, W."Heavy metals interfere with plasma metabolites, including lipids and amino acids, in patients with breast cancer". Oncology Letters 19.4 (2020): 2925-2933.
Chicago
Li, L., Zhang, M., Men, Y., Wang, W., Zhang, W."Heavy metals interfere with plasma metabolites, including lipids and amino acids, in patients with breast cancer". Oncology Letters 19, no. 4 (2020): 2925-2933. https://doi.org/10.3892/ol.2020.11402
Copy and paste a formatted citation
x
Spandidos Publications style
Li L, Zhang M, Men Y, Wang W and Zhang W: Heavy metals interfere with plasma metabolites, including lipids and amino acids, in patients with breast cancer. Oncol Lett 19: 2925-2933, 2020.
APA
Li, L., Zhang, M., Men, Y., Wang, W., & Zhang, W. (2020). Heavy metals interfere with plasma metabolites, including lipids and amino acids, in patients with breast cancer. Oncology Letters, 19, 2925-2933. https://doi.org/10.3892/ol.2020.11402
MLA
Li, L., Zhang, M., Men, Y., Wang, W., Zhang, W."Heavy metals interfere with plasma metabolites, including lipids and amino acids, in patients with breast cancer". Oncology Letters 19.4 (2020): 2925-2933.
Chicago
Li, L., Zhang, M., Men, Y., Wang, W., Zhang, W."Heavy metals interfere with plasma metabolites, including lipids and amino acids, in patients with breast cancer". Oncology Letters 19, no. 4 (2020): 2925-2933. https://doi.org/10.3892/ol.2020.11402
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