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Article Open Access

Salvage stereotactic body radiotherapy for post‑operative oligo‑recurrence of non‑small cell lung cancer: A single‑institution analysis of 59 patients

  • Authors:
    • Shuri Aoki
    • Hideomi Yamashita
    • Wataru Takahashi
    • Kanabu Nawa
    • Takeshi Ota
    • Toshikazu Imae
    • Sho Ozaki
    • Yuki Nozawa
    • Jun Nakajima
    • Masaaki Sato
    • Masaki Anraku
    • Junichi Nitadori
    • Takahiro Karasaki
    • Osamu Abe
    • Keiichi Nakagawa
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, University of Tokyo Hospital, Tokyo 113‑8655, Japan, Department of Thoracic Surgery, University of Tokyo Hospital, Tokyo 113‑8655, Japan
    Copyright: © Aoki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2695-2704
    |
    Published online on: February 17, 2020
       https://doi.org/10.3892/ol.2020.11407
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Abstract

A standard treatment for patients with early‑stage non‑small cell lung cancer (NSCLC) who undergo surgery, and subsequently develop local failure or intrathoracic oligo‑­recurrence, has not yet been established. The present study aimed to assess the feasibility of stereotactic body radiotherapy (SBRT) for this subgroup of patients. Consequently, a retrospective analysis was conducted of patients with NSCLC recurrence who were treated with SBRT, and previously underwent curative surgical resection between October 2011 and October 2016. Post‑SBRT survival [overall survival (OS); progression‑free survival (PFS); and local control (LC)] and toxicity were analyzed. Prognostic factors for OS were identified using univariate and multivariate analysis. A total of 52 patients and 59 tumors were analyzed. The median follow‑up time was 25 months (35 months for surviving patients), and median OS following salvage SBRT was 32 months. The 1‑ and 3‑year OS rates were 84.4 and 67.8%, respectively. 1‑ and 3‑year PFS rates were 80.8 and 58.7%, respectively. Only 4 patients (7.7%) developed local failure. Median LC was 71 months and 1‑ and 3‑year LC rate were 97.9 and 94.9%, respectively. A total of 4 patients experienced grade 3 or higher adverse events (AEs) and two experienced grade 5 AEs (pneumonitis and hemoptysis). Central tumor location and the possibility of re‑operation were independent prognostic factors for OS. The present study indicated that post‑operative salvage SBRT is a promising therapeutic option for patients with NSCLC with locoregional or intrathoracic oligo‑recurrence. We regard toxicity was also acceptable. However, further research is required on the appropriate selection of subjects, and stratification of the analysis by certain risk factors would increase the accuracy of the conclusions.
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1 

Asamura H, Goya T, Koshiishi Y, Sohara Y, Eguchi K, Mori M, Nakanishi Y, Tsuchiya R, Shimokata K, Inoue H, et al: A Japanese lung cancer registry study: Prognosis of 13,010 resected lung cancers. J Thorac Oncol. 3:46–52. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Goya T, Asamura H, Yoshimura H, Kato H, Shimokata K, Tsuchiya R, Sohara Y, Miya T and Miyaoka E; Japanese Joint Committee of Lung Cancer Registry, : Prognosis of 6644 resected non-small cell lung cancers in Japan: A Japanese lung cancer registry study. Lung Cancer. 50:227–234. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Sawabata N, Miyaoka E, Asamura H, Nakanishi Y, Eguchi K, Mori M, Nomori H, Fujii Y, Okumura M and Yokoi K; Japanese Joint Committee for Lung Cancer Registration, : Japanese lung cancer registry study of 11,663 surgical cases in 2004: Demographic and prognosis changes over decade. J Thorac Oncol. 6:1229–1235. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Kim E, Song C, Kim MY and Kim JS: Long-term outcomes after salvage radiotherapy for postoperative locoregionally recurrent non-small-cell lung cancer. Radiat Oncol J. 35:55–64. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Sugimura H, Nichols FC, Yang P, Allen MS, Cassivi SD, Deschamps C, Williams BA and Pairolero PC: Survival after recurrent nonsmall-cell lung cancer after complete pulmonary resection. Ann Thorac Surg. 83:409–418. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Hung JJ, Hsu WH, Hsieh CC, Huang BS, Huang MH, Liu JS and Wu YC: Post-recurrence survival in completely resected stage I non-small cell lung cancer with local recurrence. Thorax. 64:192–196. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Endo C, Sakurada A, Notsuda H, Noda M, Hoshikawa Y, Okada Y and Kondo T: Results of long-term follow-up of patients with completely resected non-small cell lung cancer. Ann Thorac Surg. 93:1061–1068. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Socinski MA, Evans T, Gettinger S, Hensing TA, VanDam Sequist L, Ireland B and Stinchcombe TE: Treatment of stage IV non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American college of chest physicians evidence-based clinical practice guidelines. Chest. 143 (Suppl 5):e341S–e368S. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Mok TS, Lee K and Leung L: Targeting epidermal growth factor receptor in the management of lung cancer. Semin Oncol. 41:101–109. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Niibe Y and Hayakawa K: Oligometastases and oligo-recurrence: The new era of cancer therapy. Jpn J Clin Oncol. 40:107–111. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Niibe Y and Chang JY: Novel insights of oligometastases and oligo-recurrence and review of the literature. Pulm Med. 2012:2610962012. View Article : Google Scholar : PubMed/NCBI

12 

Niibe Y, Chang JY, Onishi H, Salama J, Hiraki T and Yamashita H: Oligometastases/Oligo-recurrence of lung cancer. Pulm Med. 2013:4382362013. View Article : Google Scholar : PubMed/NCBI

13 

Niibe Y, Jingu K and Onishi H: Oligo-recurrence and Sync-oligometastases. J Thorac Oncol. 13:e59–e60. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Hishida T, Yoshida J, Aokage K, Nagai K and Tsuboi M: Postoperative oligo-recurrence of non-small-cell lung cancer: Clinical features and survival†. Eur J Cardiothorac Surg. 49:847–853. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Ashworth A, Rodrigues G, Boldt G and Palma D: Is there an oligometastatic state in non-small cell lung cancer? A systematic review of the literature. Lung Cancer. 82:197–203. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Niibe Y, Jingu K and Onishi H: Long-term outcome of surgery or stereotactic radiotherapy for lung oligo-recurrence. J Thorac Oncol. 12:e1912017. View Article : Google Scholar : PubMed/NCBI

17 

Yamashita H, Niibe Y, Yamamoto T, Katsui K, Jingu K, Kanazawa S, Terahara A and Nakagawa K: Lung stereotactic radiotherapy for oligometastases: Comparison of oligo-recurrence and sync-oligometastases. Jpn J Clin Oncol. 46:687–691. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Sekihara K, Hishida T, Yoshida J, Oki T, Omori T, Katsumata S, Ueda T, Miyoshi T, Goto M, Nakasone S, et al: Long-term survival outcome after postoperative recurrence of non-small-cell lung cancer: Who is ‘cured’ from postoperative recurrence? Eur J Cardiothorac Surg. 52:522–528. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Brooks ED, Verma V, Senan S, De Baere T, Lu S, Brunelli A and Chang JY; International Association for the Study of Lung Cancer Advanced Radiation Technology Committee, : Salvage therapy for locoregional recurrence after stereotactic ablative radiotherapy for early-stage NSCLC. J Thorac Onco. Nov 9–2019.(Epub ahead of print).

20 

Taylor MD, Nagji AS, Bhamidipati CM, Theodosakis N, Kozower BD, Lau CL and Jones DR: Tumor recurrence after complete resection for non-small cell lung cancer. Ann Thorac Surg. 93:1813–1821. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Voltolini L, Paladini P, Luzzi L, Ghiribelli C, Di Bisceglie M and Gotti G: Iterative surgical resections for local recurrent and second primary bronchogenic carcinoma. Eur J Cardiothorac Surg. 18:529–534. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Battafarano RJ, Force SD, Meyers BF, Bell J, Guthrie TJ, Cooper JD and Patterson GA: Benefits of resection for metachronous lung cancer. J Thorac Cardiovasc Surg. 127:836–842. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Sun B, Brooks ED, Komaki R, Liao Z, Jeter M, McAleer M, Balter PA, Welsh JD, O'Reilly M, Gomez D, et al: Long-term outcomes of salvage stereotactic ablative radiotherapy for isolated lung recurrence of non-small cell lung cancer: A phase II clinical trial. J Thorac Oncol. 12:983–992. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Saisho S, Yasuda K, Maeda A, Yukawa T, Okita R, Hirami Y, Shimizu K and Nakata M: Post-recurrence survival of patients with non-small-cell lung cancer after curative resection with or without induction/adjuvant chemotherapy. Interact Cardiovasc Thorac Surg. 16:166–172. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Lee K, Kim HR, Kim DK, Kim YH, Park SI, Choi SH and Han J: Post-recurrence survival analysis of stage I non-small-cell lung cancer. Asian Cardiovasc Thorac Ann. 25:623–629. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Ricardi U, Badellino S and Filippi AR: Stereotactic radiotherapy for early stage non-small cell lung cancer. Radiat Oncol J. 33:57–65. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Crabtree TD, Denlinger CE, Meyers BF, El Naqa I, Zoole J, Krupnick AS, Kreisel D, Patterson GA and Bradley JD: Stereotactic body radiation therapy versus surgical resection for stage I non-small cell lung cancer. J Thorac Cardiovasc Surg. 140:377–386. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Kimura T, Nagata Y, Eba J, Ozawa S, Ishikura S, Shibata T, Ito Y, Hiraoka M and Nishimura Y; Radiation Oncology Study Group of the Japan Clinical Oncology Group, : A randomized phase III trial of comparing two dose-fractionations stereotactic body radiotherapy (SBRT) for medically inoperable stage IA non-small cell lung cancer or small lung lesions clinically diagnosed as primary lung cancer: Japan clinical oncology group study JCOG1408 (J-SBRT trial). Jpn J Clin Oncol. 47:277–281. 2017.PubMed/NCBI

29 

Rosen JE, Salazar MC, Wang Z, Yu JB, Decker RH, Kim AW, Detterbeck FC and Boffa DJ: Lobectomy versus stereotactic body radiotherapy in healthy patients with stage I lung cancer. J Thorac Cardiovasc Surg. 152:44–54.e9. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Chang JY, Liu YH, Zhu Z, Welsh JW, Gomez DR, Komaki R, Roth JA and Swisher SG: Stereotactic ablative radiotherapy: A potentially curable approach to early stage multiple primary lung cancer. Cancer. 119:3402–3410. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Chang JY, Senan S, Paul MA, Mehran RJ, Louie AV, Balter P, Groen HJ, McRae SE, Widder J, Feng L, et al: Stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small-cell lung cancer: A pooled analysis of two randomised trials. Lancet Oncol. 16:630–637. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Onimaru R, Shirato H, Shibata T, Hiraoka M, Ishikura S, Karasawa K, Matsuo Y, Kokubo M, Shioyama Y, Matsushita H, et al: Phase I study of stereotactic body radiation therapy for peripheral T2N0M0 non-small cell lung cancer with PTV<100 cc using a continual reassessment method (JCOG0702). Radiother Oncol. 116:276–280. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Verma V, Shostrom VK, Zhen W, Zhang M, Braunstein SE, Holland J, Hallemeier CL, Harkenrider MM, Iskhanian A, Jabbour SK, et al: Influence of fractionation scheme and tumor location on toxicities after stereotactic body radiation therapy for large (≥5 cm) non-small cell lung cancer: A multi-institutional analysis. Int J Radiat Oncol Biol Phys. 97:778–785. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Iyengar P, Wardak Z, Gerber DE, Tumati V, Ahn C, Hughes RS, Dowell JE, Cheedella N, Nedzi L, Westover KD, et al: Consolidative radiotherapy for limited metastatic non-small-cell lung cancer: A phase 2 randomized clinical trial. JAMA Oncol. 4:e1735012018. View Article : Google Scholar : PubMed/NCBI

35 

Wang HH, Zaorsky NG, Meng MB, Zeng XL, Deng L, Song YC, Zhuang HQ, Li FT, Zhao LJ, Yuan ZY, et al: Stereotactic radiation therapy for oligometastases or oligorecurrence within mediastinal lymph nodes. Oncotarget. 7:18135–18145. 2016.PubMed/NCBI

36 

Sobin LH, Gospodarowicz MK and Wittekind C: International Union Against Cancer (UICC): TNM classification of malignant tumours. 7th. Wiley-Blackwell; Oxford: 2009

37 

Yamashita H, Takahashi W, Haga A, Kida S, Saotome N and Nakagawa K: Stereotactic body radiotherapy for small lung tumors in the University of Tokyo hospital. Biomed Res Int. 2014:1365132014. View Article : Google Scholar : PubMed/NCBI

38 

Nakagawa K, Haga A, Kida S, Masutani Y, Yamashita H, Takahashi W, Sakumi A, Saotome N, Shiraki T, Ohtomo K, et al: 4D registration and 4D verification of lung tumor position for stereotactic volumetric modulated arc therapy using respiratory-correlated cone-beam CT. J Radiat Res. 54:152–156. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Nakagawa K, Haga A, Sakumi A, Yamashita H, Igaki H, Shiraki T, Ohtomo K, Iwai Y and Yoda K: Impact of flattening-filter-free techniques on delivery time for lung stereotactic volumetric modulated arc therapy and image quality of concurrent kilovoltage cone-beam computed tomography: A preliminary phantom study. J Radiat Res. 55:200–202. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Timmerman R, Paulus R, Galvin J, Michalski J, Straube W, Bradley J, Fakiris A, Bezjak A, Videtic G, Johnstone D, et al: Stereotactic body radiation therapy for medically inoperable early stage lung cancer. JAMA. 303:1070–1076. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Aoki S, Yamashita H, Haga A, Nawa K, Imae T, Takahashi W, Abe O and Nakagawa K: Flattening filter-free technique in volumetric modulated arc therapy for lung stereotactic body radiotherapy: A clinical comparison with the flattening filter technique. Oncol Lett. 15:3928–3936. 2018.PubMed/NCBI

42 

Aoki S, Yamashita H, Haga A, Ota T, Takahashi W, Ozaki S, Nawa K, Imae T, Abe O and Nakagawa K: Stereotactic body radiotherapy for centrally-located lung tumors with 56 Gy in seven fractions: A retrospective study. Oncol Lett. 16:4498–4506. 2018.PubMed/NCBI

43 

Ahnesjö A: Collapsed cone convolution of radiant energy for photon dose calculation in heterogeneous media. Med Phys. 16:577–592. 1989. View Article : Google Scholar : PubMed/NCBI

44 

Roesch J, Panje C, Sterzing F, Mantel F, Nestle U, Andratschke N and Guckenberger M: SBRT for centrally localized NSCLC-What is too central? Radiat Oncol. 11:1572016. View Article : Google Scholar : PubMed/NCBI

45 

Meng MB, Wang HH, Zaorsky NG, Sun BS, Zhu L, Song YC, Li FT, Dong Y, Wang JS, Chen HM, et al: Risk-adapted stereotactic body radiation therapy for central and ultra-central early-stage inoperable non-small cell lung cancer. Cancer Sci. 110:3553–3564. 2019. View Article : Google Scholar : PubMed/NCBI

46 

Chang JH, Poon I, Erler D, Zhang L and Cheung P: The safety and effectiveness of stereotactic body radiotherapy for central versus ultracentral lung tumors. Radiother Oncol. 129:277–283. 2018. View Article : Google Scholar : PubMed/NCBI

47 

Chaudhuri AA, Tang C, Binkley MS, Jin M, Wynne JF, von Eyben R, Hara WY, Trakul N, Loo BW Jr and Diehn M: Stereotactic ablative radiotherapy (SABR) for treatment of central and ultra-central lung tumors. Lung Cancer. 89:50–56. 2015. View Article : Google Scholar : PubMed/NCBI

48 

Nagata Y, Hiraoka M, Shibata T, Onishi H, Kokubo M, Karasawa K, Shioyama Y, Onimaru R, Kozuka T, Kunieda E, et al: Prospective trial of stereotactic body radiation therapy for both operable and inoperable T1N0M0 non-small cell lung cancer: Japan clinical oncology group study JCOG0403. Int J Radiat Oncol Biol Phys. 93:989–996. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Sapkaroski D, Osborne C and Knight KA: A review of stereotactic body radiotherapy-is volumetric modulated arc therapy the answer? J Med Radiat Sci. 62:142–151. 2015. View Article : Google Scholar : PubMed/NCBI

50 

Jiang X, Li T, Liu Y, Zhou L, Xu Y, Zhou X and Gong Y: Planning analysis for locally advanced lung cancer: Dosimetric and efficiency comparisons between intensity-modulated radiotherapy (IMRT), single-arc/partial-arc volumetric modulated arc therapy (SA/PA-VMAT). Radiat Oncol. 6:1402011. View Article : Google Scholar : PubMed/NCBI

51 

Yamashita H, Haga A, Takahashi W, Takenaka R, Imae T, Takenaka S and Nakagawa K: Volumetric modulated arc therapy for lung stereotactic radiation therapy can achieve high local control rates. Radiat Oncol. 9:2432014. View Article : Google Scholar : PubMed/NCBI

52 

Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0 Published, (v4.03, June 14, 2010). 2009.

53 

Kanda Y: Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 48:452–458. 2013. View Article : Google Scholar : PubMed/NCBI

54 

Dale RG: The application of the linear-quadratic dose-effect equation to fractionated and protracted radiotherapy. Br J Radiol. 58:515–528. 1985. View Article : Google Scholar : PubMed/NCBI

55 

Puri V, Crabtree TD, Bell JM, Kreisel D, Krupnick AS, Broderick S, Patterson GA and Meyers BF: National cooperative group trials of ‘high-risk’ patients with lung cancer: Are they truly ‘high-risk’? Ann Thorac Surg. 97:1678–1685. 2014. View Article : Google Scholar : PubMed/NCBI

56 

Ferguson MK, Watson S, Johnson E and Vigneswaran WT: Predicted postoperative lung function is associated with all-cause long-term mortality after major lung resection for cancer. Eur J Cardiothorac Surg. 45:660–664. 2014. View Article : Google Scholar : PubMed/NCBI

57 

Kim GJ, Koshy M, Hanlon AL, Horiba MN, Edelman MJ, Burrows WM, Battafarano RJ and Suntharalingam M: The benefit of chemotherapy in esophageal cancer patients with residual disease after trimodality therapy. Am J Clin Oncol. 39:136–141. 2016. View Article : Google Scholar : PubMed/NCBI

58 

Yukiue H, Tanahashi M, Haneda H, Suzuki E, Yoshii N and Niwa H: Surgical treatment for recurrent and second primary lung cancer. Kyobu Geka. 63:944–949. 2010.(In Japanese). PubMed/NCBI

59 

Subotic D, Molins L, Soldatovic I, Moskovljevic D, Collado L and Hernández J: Completion pneumonectomy: A valuable option for lung cancer recurrence or new primaries. World J Surg Oncol. 16:982018. View Article : Google Scholar : PubMed/NCBI

60 

Takeda A, Sanuki N, Eriguchi T, Enomoto T, Yokosuka T, Kaneko T, Handa H, Aoki Y, Oku Y and Kunieda E: Salvage stereotactic ablative irradiation for isolated postsurgical local recurrence of lung cancer. Ann Thorac Surg. 96:1776–1782. 2013. View Article : Google Scholar : PubMed/NCBI

61 

Nishiyama K, Kodama K, Teshima T and Tada H: Stereotactic body radiotherapy for second pulmonary nodules after operation for an initial lung cancer. Jpn J Clin Oncol. 45:947–952. 2015. View Article : Google Scholar : PubMed/NCBI

62 

Kelsey CR, Clough RW and Marks LB: Local recurrence following initial resection of NSCLC: Salvage is possible with radiation therapy. Cancer J. 12:283–288. 2006. View Article : Google Scholar : PubMed/NCBI

63 

Gagliasso M, Migliaretti G and Ardissone F: Assessing the prognostic impact of the international association for the study of lung cancer proposed definitions of complete, uncertain, and incomplete resection in non-small cell lung cancer surgery. Lung Cancer. 111:124–130. 2017. View Article : Google Scholar : PubMed/NCBI

64 

Yoshino I, Yohena T, Kitajima M, Ushijima C, Nishioka K, Ichinose Y and Sugimachi K: Survival of non-small cell lung cancer patients with postoperative recurrence at distant organs. Ann Thorac Cardiovasc Surg. 7:204–209. 2001.PubMed/NCBI

65 

Sasaki H, Suzuki A, Tatematsu T, Shitara M, Hikosaka Y, Okuda K, Moriyama S, Yano M and Fujii Y: Prognosis of recurrent non-small cell lung cancer following complete resection. Oncol Lett. 7:1300–1304. 2014. View Article : Google Scholar : PubMed/NCBI

66 

Walsh GL, O'Connor M, Willis KM, Milas M, Wong RS, Nesbitt JC, Putnam JB Jr, Lee JJ and Roth JA: Is follow-up of lung cancer patients after resection medically indicated and cost-effective? Ann Thorac Surg. 60:1563–1570. 1995. View Article : Google Scholar : PubMed/NCBI

67 

Ichinose Y, Kato H, Koike T, Tsuchiya R, Fujisawa T, Shimizu N, Watanabe Y, Mitsudomi T and Yoshimura M; Japan Clinical Oncology Group, : Overall survival and local recurrence of 406 completely resected stage IIIa-N2 non-small cell lung cancer patients: Questionnaire survey of the Japan clinical oncology group to plan for clinical trials. Lung Cancer. 34:29–36. 2001. View Article : Google Scholar : PubMed/NCBI

68 

Kagami Y, Nishio M, Narimatsu N, Mjoujin M, Sakurai T, Hareyama M and Saito A: Radiotherapy for locoregional recurrent tumors after resection of non-small cell lung cancer. Lung Cancer. 20:31–35. 1998. View Article : Google Scholar : PubMed/NCBI

69 

Jeremic B and Bamberg M: External beam radiation therapy for bronchial stump recurrence of non-small-cell lung cancer after complete resection. Radiother Oncol. 64:251–257. 2002. View Article : Google Scholar : PubMed/NCBI

70 

Timmerman R, McGarry R, Yiannoutsos C, Papiez L, Tudor K, DeLuca J, Ewing M, Abdulrahman R, DesRosiers C, Williams M and Fletcher J: Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer. J Clin Oncol. 24:4833–4839. 2006. View Article : Google Scholar : PubMed/NCBI

71 

Oskan F: The quality of toxicity reporting and the story of the lung SBRT ‘No-Fly Zone’. Int J Radiat Oncol Biol Phys. 92:514–515. 2015. View Article : Google Scholar : PubMed/NCBI

72 

Timmerman RD: The quality of toxicity reporting and the story of the lung SBRT ‘No-Fly Zone’. In Regard to Oskan. Int J Radiat Oncol Biol Phys. 93:726–727. 2015. View Article : Google Scholar : PubMed/NCBI

73 

Song KJ and Flores RM: Is survival after sublobar resection vs. lobectomy made equivalent by extent of lymphadenectomy? Ann Transl Med. 7 (Suppl 6):S1912019.PubMed/NCBI

74 

Hattori A, Matsunaga T, Takamochi K, Oh S and Suzuki K: Locoregional recurrence after segmentectomy for clinical-T1aN0M0 radiologically solid non-small-cell lung carcinoma. Eur J Cardiothorac Surg. 51:518–525. 2017.PubMed/NCBI

75 

Kim H, Pyo H, Noh JM, Lee W, Park B, Park HY and Yoo H: Preliminary result of definitive radiotherapy in patients with non-small cell lung cancer who have underlying idiopathic pulmonary fibrosis: Comparison between X-ray and proton therapy. Radiat Oncol. 14:192019. View Article : Google Scholar : PubMed/NCBI

76 

Yamaguchi S, Ohguri T, Ide S, Aoki T, Imada H, Yahara K, Narisada H and Korogi Y: Stereotactic body radiotherapy for lung tumors in patients with subclinical interstitial lung disease: The potential risk of extensive radiation pneumonitis. Lung Cancer. 82:260–265. 2013. View Article : Google Scholar : PubMed/NCBI

77 

Glick D, Lyen S, Kandel S, Shapera S, Le LW, Lindsay P, Wong O, Bezjak A, Brade A, Cho BCJ, et al: Impact of pretreatment interstitial lung disease on radiation pneumonitis and survival in patients treated with lung stereotactic body radiation therapy (SBRT). Clin Lung Cancer. 19:e219–e226. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Aoki S, Yamashita H, Takahashi W, Nawa K, Ota T, Imae T, Ozaki S, Nozawa Y, Nakajima J, Sato M, Sato M, et al: Salvage stereotactic body radiotherapy for post‑operative oligo‑recurrence of non‑small cell lung cancer: A single‑institution analysis of 59 patients. Oncol Lett 19: 2695-2704, 2020.
APA
Aoki, S., Yamashita, H., Takahashi, W., Nawa, K., Ota, T., Imae, T. ... Nakagawa, K. (2020). Salvage stereotactic body radiotherapy for post‑operative oligo‑recurrence of non‑small cell lung cancer: A single‑institution analysis of 59 patients. Oncology Letters, 19, 2695-2704. https://doi.org/10.3892/ol.2020.11407
MLA
Aoki, S., Yamashita, H., Takahashi, W., Nawa, K., Ota, T., Imae, T., Ozaki, S., Nozawa, Y., Nakajima, J., Sato, M., Anraku, M., Nitadori, J., Karasaki, T., Abe, O., Nakagawa, K."Salvage stereotactic body radiotherapy for post‑operative oligo‑recurrence of non‑small cell lung cancer: A single‑institution analysis of 59 patients". Oncology Letters 19.4 (2020): 2695-2704.
Chicago
Aoki, S., Yamashita, H., Takahashi, W., Nawa, K., Ota, T., Imae, T., Ozaki, S., Nozawa, Y., Nakajima, J., Sato, M., Anraku, M., Nitadori, J., Karasaki, T., Abe, O., Nakagawa, K."Salvage stereotactic body radiotherapy for post‑operative oligo‑recurrence of non‑small cell lung cancer: A single‑institution analysis of 59 patients". Oncology Letters 19, no. 4 (2020): 2695-2704. https://doi.org/10.3892/ol.2020.11407
Copy and paste a formatted citation
x
Spandidos Publications style
Aoki S, Yamashita H, Takahashi W, Nawa K, Ota T, Imae T, Ozaki S, Nozawa Y, Nakajima J, Sato M, Sato M, et al: Salvage stereotactic body radiotherapy for post‑operative oligo‑recurrence of non‑small cell lung cancer: A single‑institution analysis of 59 patients. Oncol Lett 19: 2695-2704, 2020.
APA
Aoki, S., Yamashita, H., Takahashi, W., Nawa, K., Ota, T., Imae, T. ... Nakagawa, K. (2020). Salvage stereotactic body radiotherapy for post‑operative oligo‑recurrence of non‑small cell lung cancer: A single‑institution analysis of 59 patients. Oncology Letters, 19, 2695-2704. https://doi.org/10.3892/ol.2020.11407
MLA
Aoki, S., Yamashita, H., Takahashi, W., Nawa, K., Ota, T., Imae, T., Ozaki, S., Nozawa, Y., Nakajima, J., Sato, M., Anraku, M., Nitadori, J., Karasaki, T., Abe, O., Nakagawa, K."Salvage stereotactic body radiotherapy for post‑operative oligo‑recurrence of non‑small cell lung cancer: A single‑institution analysis of 59 patients". Oncology Letters 19.4 (2020): 2695-2704.
Chicago
Aoki, S., Yamashita, H., Takahashi, W., Nawa, K., Ota, T., Imae, T., Ozaki, S., Nozawa, Y., Nakajima, J., Sato, M., Anraku, M., Nitadori, J., Karasaki, T., Abe, O., Nakagawa, K."Salvage stereotactic body radiotherapy for post‑operative oligo‑recurrence of non‑small cell lung cancer: A single‑institution analysis of 59 patients". Oncology Letters 19, no. 4 (2020): 2695-2704. https://doi.org/10.3892/ol.2020.11407
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