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Article Open Access

Comprehensive genomic profile of cholangiocarcinomas in China

  • Authors:
    • Weijun Tian
    • Weiyu Hu
    • Xiaoling Shi
    • Peng Liu
    • Xiang Ma
    • Wei Zhao
    • Linlin Qu
    • Shuirong Zhang
    • Weiwei Shi
    • Angen Liu
    • Jingyu Cao
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China, Department of Hepatobiliary Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China, Origimed Co. Ltd, Shanghai 201114, P.R. China
    Copyright: © Tian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3101-3110
    |
    Published online on: March 3, 2020
       https://doi.org/10.3892/ol.2020.11429
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Abstract

Cholangiocarcinoma (CCA) is a primary malignancy, which is often diagnosed as locally advanced or metastatic. Previous studies have revealed genomic characteristics of CCA in Western patients, however comprehensive genomic features of CCA in Chinese patients have not been well understood. To explore the specific genomic characteristics of Chinese patients with CCA, a total of 66 patients with CCA, including 44 intrahepatic CCA (iCCA) and 22 extrahepatic CCA (exCCA) cases, were studied. The most commonly altered genes in CCAs were TP53 (62.12%, 41/66), KRAS (36.36%, 24/66), SMAD4 (24.24%, 16/66), TERT (21.21%, 14/66), ARID1A (19.70%, 13/66), CDKN2A (19.70%, 13/66), KMT2C (9.09%, 6/66) and RBM10 (9.09%, 6/66), ERBB2 (7.58%, 5/66) and BRAF (7.58%, 5/66). Many gene mutations, including STK11, CCND1 and FGF19, were only found in iCCA. RBM10 mutations were found to be significantly higher in exCCA. The gene mutations of neurofibromin 1, STK11, CCND1 and FBXW7 specifically occurred in males, whereas gene mutations of ERBB2, AXIN2 and CREBBP specifically occurred in females. ERBB2 mutations were significantly associated with the sex of patients with CCA. Mutations in PIK3CA, FGFR2 and ZNF750 were significantly associated with the age of patients with CCA and TERT mutations were significantly associated with tumor differentiation. Alterations in KMT2C, PBRM1, AXIN2, MAGI2, BRCA2 and SPTA1 were associated with tumor mutational burden. The findings of the present study suggest that targeted sequencing, using next‑generation sequencing technology, provides comprehensive and accurate information on genomic alterations, which will provide novel potential biomarkers for the diagnosis of CCA and may guide precise therapeutic strategies for Chinese patients with CCA.
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Copy and paste a formatted citation
Spandidos Publications style
Tian W, Hu W, Shi X, Liu P, Ma X, Zhao W, Qu L, Zhang S, Shi W, Liu A, Liu A, et al: Comprehensive genomic profile of cholangiocarcinomas in China. Oncol Lett 19: 3101-3110, 2020.
APA
Tian, W., Hu, W., Shi, X., Liu, P., Ma, X., Zhao, W. ... Cao, J. (2020). Comprehensive genomic profile of cholangiocarcinomas in China. Oncology Letters, 19, 3101-3110. https://doi.org/10.3892/ol.2020.11429
MLA
Tian, W., Hu, W., Shi, X., Liu, P., Ma, X., Zhao, W., Qu, L., Zhang, S., Shi, W., Liu, A., Cao, J."Comprehensive genomic profile of cholangiocarcinomas in China". Oncology Letters 19.4 (2020): 3101-3110.
Chicago
Tian, W., Hu, W., Shi, X., Liu, P., Ma, X., Zhao, W., Qu, L., Zhang, S., Shi, W., Liu, A., Cao, J."Comprehensive genomic profile of cholangiocarcinomas in China". Oncology Letters 19, no. 4 (2020): 3101-3110. https://doi.org/10.3892/ol.2020.11429
Copy and paste a formatted citation
x
Spandidos Publications style
Tian W, Hu W, Shi X, Liu P, Ma X, Zhao W, Qu L, Zhang S, Shi W, Liu A, Liu A, et al: Comprehensive genomic profile of cholangiocarcinomas in China. Oncol Lett 19: 3101-3110, 2020.
APA
Tian, W., Hu, W., Shi, X., Liu, P., Ma, X., Zhao, W. ... Cao, J. (2020). Comprehensive genomic profile of cholangiocarcinomas in China. Oncology Letters, 19, 3101-3110. https://doi.org/10.3892/ol.2020.11429
MLA
Tian, W., Hu, W., Shi, X., Liu, P., Ma, X., Zhao, W., Qu, L., Zhang, S., Shi, W., Liu, A., Cao, J."Comprehensive genomic profile of cholangiocarcinomas in China". Oncology Letters 19.4 (2020): 3101-3110.
Chicago
Tian, W., Hu, W., Shi, X., Liu, P., Ma, X., Zhao, W., Qu, L., Zhang, S., Shi, W., Liu, A., Cao, J."Comprehensive genomic profile of cholangiocarcinomas in China". Oncology Letters 19, no. 4 (2020): 3101-3110. https://doi.org/10.3892/ol.2020.11429
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