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Article Open Access

Methylated PTGER4 is better than CA125, CEA, Cyfra211 and NSE as a therapeutic response assessment marker in stage IV lung cancer

  • Authors:
    • Yunxia Zhang
    • Jianfeng Huang
    • Qinzhou Zou
    • Jun Che
    • Kaihua Yang
    • Qiang Fan
    • Danqi Qian
    • Jia Wu
    • Erwen Bao
    • Lele Song
    • Fuzheng Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Radiotherapy, The Affiliated Hospital of Jiangnan University, Binhu, Wuxi, Jiangsu 214062, P.R. China, Department of Radiotherapy, The Eighth Medical Center of The Chinese People's Liberation Army General Hospital, Haidian, Beijing 100091, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3229-3238
    |
    Published online on: March 3, 2020
       https://doi.org/10.3892/ol.2020.11434
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Abstract

Real‑time assessment of therapeutic response in patients with advanced lung cancer presents a major challenge throughout the treatment process. Currently, computed tomography imaging is often used; however, it is radiation‑based and hysteretic and is not suitable for repeated use as a real‑time assessment. Blood biomarkers represent a novel solution for assessing therapeutic response in patients with advanced lung cancer. In the present study, the efficacy of a methylation marker [methylated prostaglandin E receptor 4 (mPTGER4)] and four protein markers [carcinoma antigen 125 (CA125), carcinoembryonic antigen (CEA), cytokeratin 19‑fragments (cyfra21‑1) and neuron‑specific enolase (NSE)] were simultaneously evaluated to determine their potential in facilitating therapeutic response monitoring as well as their prognostic values in patients with stage IV lung cancer. The results indicated that, following treatment, the blood levels of methylated PTGER4 and NSE had significantly decreased, and mPRGER4, CA125, CEA and NSE exhibited a significant decrease in percentage level. Since mPTGER4 exhibited a higher rate of positive detection prior to therapy, and a greater response of sensitivity to therapy compared to the protein markers, it may represent an improved marker for the monitoring of therapeutic response. The efficacy of the markers in predicting the overall survival (OS) rate of patients with stage IV lung cancer was also assessed. Results from the follow‑up of patients (up to 891 days) revealed that the blood levels of mPTGER4, CA125 and NSE before treatment were able to predict overall survival (OS) rate. Additionally, the percentage change in expression levels of CA125, CEA and NSE was also able to predict the OS rate. In conclusion, the present results indicate that mPTGER4 represents an improved biomarker for monitoring therapeutic efficacy compared with CA125, CEA, Cyfra21‑1 and NSE. In predicting the long‑term survival of patients with stage IV lung cancer; however, the pre‑treatment levels of mPTGER4, CA125 and NSE and the percentage changes of CA125, CEA and NSE may be used as the markers.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Huang J, Zou Q, Che J, Yang K, Fan Q, Qian D, Wu J, Bao E, Song L, Song L, et al: Methylated PTGER4 is better than CA125, CEA, Cyfra211 and NSE as a therapeutic response assessment marker in stage IV lung cancer. Oncol Lett 19: 3229-3238, 2020.
APA
Zhang, Y., Huang, J., Zou, Q., Che, J., Yang, K., Fan, Q. ... Zhang, F. (2020). Methylated PTGER4 is better than CA125, CEA, Cyfra211 and NSE as a therapeutic response assessment marker in stage IV lung cancer. Oncology Letters, 19, 3229-3238. https://doi.org/10.3892/ol.2020.11434
MLA
Zhang, Y., Huang, J., Zou, Q., Che, J., Yang, K., Fan, Q., Qian, D., Wu, J., Bao, E., Song, L., Zhang, F."Methylated PTGER4 is better than CA125, CEA, Cyfra211 and NSE as a therapeutic response assessment marker in stage IV lung cancer". Oncology Letters 19.4 (2020): 3229-3238.
Chicago
Zhang, Y., Huang, J., Zou, Q., Che, J., Yang, K., Fan, Q., Qian, D., Wu, J., Bao, E., Song, L., Zhang, F."Methylated PTGER4 is better than CA125, CEA, Cyfra211 and NSE as a therapeutic response assessment marker in stage IV lung cancer". Oncology Letters 19, no. 4 (2020): 3229-3238. https://doi.org/10.3892/ol.2020.11434
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Huang J, Zou Q, Che J, Yang K, Fan Q, Qian D, Wu J, Bao E, Song L, Song L, et al: Methylated PTGER4 is better than CA125, CEA, Cyfra211 and NSE as a therapeutic response assessment marker in stage IV lung cancer. Oncol Lett 19: 3229-3238, 2020.
APA
Zhang, Y., Huang, J., Zou, Q., Che, J., Yang, K., Fan, Q. ... Zhang, F. (2020). Methylated PTGER4 is better than CA125, CEA, Cyfra211 and NSE as a therapeutic response assessment marker in stage IV lung cancer. Oncology Letters, 19, 3229-3238. https://doi.org/10.3892/ol.2020.11434
MLA
Zhang, Y., Huang, J., Zou, Q., Che, J., Yang, K., Fan, Q., Qian, D., Wu, J., Bao, E., Song, L., Zhang, F."Methylated PTGER4 is better than CA125, CEA, Cyfra211 and NSE as a therapeutic response assessment marker in stage IV lung cancer". Oncology Letters 19.4 (2020): 3229-3238.
Chicago
Zhang, Y., Huang, J., Zou, Q., Che, J., Yang, K., Fan, Q., Qian, D., Wu, J., Bao, E., Song, L., Zhang, F."Methylated PTGER4 is better than CA125, CEA, Cyfra211 and NSE as a therapeutic response assessment marker in stage IV lung cancer". Oncology Letters 19, no. 4 (2020): 3229-3238. https://doi.org/10.3892/ol.2020.11434
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