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Differential behavior of NF‑κB, IκBα and EGFR during the renal carcinogenic process in an experimental model in vivo

  • Authors:
    • Telma Pariente‑Pérez
    • Francisco Aguilar‑Alonso
    • José Dolores Solano
    • Chabetty Vargas‑Olvera
    • Patricia Curiel‑Muñiz
    • Carmen Adriana Mendoza‑Rodríguez
    • Daniela Tenorio‑Hernández
    • María Elena Ibarra‑Rubio
  • View Affiliations / Copyright

    Affiliations: Biology Department, Faculty of Chemistry, Laboratories 1F‑225, National Autonomous University of Mexico, CDMX 04510, Mexico, Biology Department, Faculty of Chemistry, Laboratories 2F‑323, National Autonomous University of Mexico, CDMX 04510, Mexico
    Copyright: © Pariente‑Pérez et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3153-3164
    |
    Published online on: March 3, 2020
       https://doi.org/10.3892/ol.2020.11436
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Abstract

Renal cell carcinoma (RCC) is the most common type of cancer of the adult kidney. It is generally asymptomatic even at advanced stages, so opportune diagnosis is rare, making it almost impossible to study this cancer at its early stages. RCC tumors induced by ferric nitrilotriacetate (FeNTA) in rats histologically correspond to the human clear cell RCC subtype (ccRCC) and the exposure to this carcinogen during either one or two months leads to different early stages of neoplastic development. High levels of nuclear factor kappa B (NF‑κB) and epidermal growth factor receptor (EGFR) as well as low levels of NF‑κB inhibitor alpha (IκBα) are frequent in human RCC, but their status in FeNTA‑induced tumors and their evolution along renal carcinogenesis is unclear. On this basis, in the present study NF‑κB, IκBα and EGFR behavior was analyzed at different stages of the experimental renal carcinogenesis model. Similar to patients with RCC, neoplastic tissue showed high levels of p65, one of the predominant subunits of NF‑κB in ccRCC and of EGFR (protein and mRNA), as well as a decrease in the levels of NF‑κB's main inhibitor, IκBα, resulting in a classic oncogenic combination. Conversely, different responses were observed at early stages of carcinogenesis. After one month of FeNTA‑exposure, NF‑κB activity and EGFR levels augmented; but unexpectedly, IκBα also did. While after two months, NF‑κB activity diminished, but EGFR and IκBα levels remained elevated. In conclusion, FeNTA‑induced tumors and RCC human neoplasms are analogues regarding to the classic NF‑κB, IκBα and EGFR behavior, and distinctive non‑conventional combination of changes is developed at each early stage studied. The results obtained suggest that the dysregulation of the analyzed molecules could be related to different signaling pathways and therefore, to particular effects depending on the phase of the carcinogenic process.
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1 

Makhov P, Joshi S, Ghatalia P, Kutikov A, Uzzo RG and Kolenko VM: Resistance to systemic therapies in clear cell renal cell carcinoma: Mechanisms and management strategies. Mol Cancer Ther. 17:1355–1364. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Peri S, Devarajan K, Yang DH, Knudson AG and Balachandran S: Meta-analysis identifies NF-κB as a therapeutic target in renal cancer. PLoS One. 8:e767462013. View Article : Google Scholar : PubMed/NCBI

3 

Morais C, Gobe G, Johnson DW and Healy H: The emerging role of nuclear factor kappa B in renal cell carcinoma. Int J Biochem Cell Biol. 43:1537–1549. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Muglia VF and Prando A: Renal cell carcinoma: Histological classification and correlation with imaging findings. Radiol Bras. 48:166–174. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Aguilar-Alonso FA, Solano JD, Vargas-Olvera CY, Pacheco-Bernal I, Pariente-Pérez TO and Ibarra-Rubio ME: MAPKs' status at early stages of renal carcinogenesis and tumors induced by ferric nitrilotriacetate. Mol Cell Biochem. 404:161–170. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Vargas-Olvera CY, Sánchez-González DJ, Solano JD, Aguilar-Alonso FA, Montalvo-Muñoz F, Martínez-Martínez CM, Medina-Campos ON and Ibarra-Rubio ME: Characterization of N-diethylnitrosamine-initiated and ferric nitrilotriacetate-promoted renal cell carcinoma experimental model and effect of a tamarind seed extract against acute nephrotoxicity and carcinogenesis. Mol Cell Biochem. 369:105–117. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Mitchell S, Vargas J and Hoffmann A: Signaling via the NFκB system. Wiley Interdiscip Rev Syst Biol Med. 8:227–241. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Hayden MS and Ghosh S: Regulation of NF-κB by TNF family cytokines. Semin Immunol. 26:253–266. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Desterro JM, Rodriguez MS and Hay RT: SUMO-1 modification of IκBα inhibits NF-kappaB activation. Mol Cell. 2:233–239. 1998. View Article : Google Scholar : PubMed/NCBI

10 

Renard P, Percherancier Y, Kroll M, Thomas D, Virelizier JL, Arenzana F and Bachelerie F: Inducible NF-kappaB activation is permitted by simultaneous degradation of nuclear IkappaBalpha. J Biol Chem. 275:15193–15199. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Lua J, Qayyum T, Edwards J and Roseweir AK: The prognostic role of the non-canonical nuclear factor-kappa B pathway in renal cell carcinoma patients. Urol Int. 101:190–196. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Meteoglu I, Erdogdu IH, Meydan N, Erkus M and Barutca S: NF-kappaB expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissues. J Exp Clin Cancer Res. 27:532008. View Article : Google Scholar : PubMed/NCBI

13 

Morais C, Pat B, Gobe G, Johnson DW and Healy H: Pyrrolidine dithiocarbamate exerts anti-proliferative and pro-apoptotic effects in renal cell carcinoma cell lines. Nephrol Dial Transplant. 21:3377–3388. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Oya M, Takayanagi A, Horiguchi A, Mizuno R, Ohtsubo M, Marumo K, Shimizu N and Murai M: Increased nuclear factor-κB activation is related to the tumor development of renal cell carcinoma. Carcinogenesis. 24:377–384. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Sourbier C, Danilin S, Lindner V, Steger J, Rothhut S, Meyer N, Jacqmin D, Helwig JJ, Lang H and Massfelder T: Targeting the nuclear factor-κB rescue pathway has promising future in human renal cell carcinoma therapy. Cancer Res. 67:11668–11676. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Đorđević G, Matušan-Ilijaš K, Sinožić E, Damante G, Fabbro D, Grahovac B, Lučin K and Jonjić N: Relationship between vascular endothelial growth factor and nuclear factor-κB in renal cell tumors. Croat Med J. 49:608–617. 2008. View Article : Google Scholar : PubMed/NCBI

17 

An J and Rettig MB: Epidermal growth factor receptor inhibition sensitizes renal cell carcinoma cells to the cytotoxic effects of bortezomib. Mol Cancer Ther. 6:61–69. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Oka D, Nishimura K, Shiba M, Nakai Y, Arai Y, Nakayama M, Takayama H, Inoue H, Okuyama A and Nonomura N: Sesquiterpene lactone parthenolide suppresses tumor growth in a xenograft model of renal cell carcinoma by inhibiting the activation of NF-kappaB. Int J Cancer. 120:2576–2581. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Ng KL, Yap NY, Rajandram R, Small D, Pailoor J, Ong TA, Razack AH, Wood ST, Morais C and Gobe GC: Nuclear factor-kappa B subunits and their prognostic cancer-specific survival value in renal cell carcinoma patients. Pathology. 50:511–518. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Thornburg NJ and Raab-Traub N: Induction of epidermal growth factor receptor expression by Epstein-barr virus latent membrane protein 1 C-terminal-activating region 1 is mediated by NF-κB p50 Homodimer/Bcl-3 complexes. J Virol. 81:12954–12961. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Staruschenko A, Palygin O, Ilatovskaya DV and Pavlov TS: Epidermal growth factors in the kidney and relationship to hypertension. Am J Physiol Renal Physiol. 305:F12–F20. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Zeng F, Singh AB and Harris RC: The role of the EGF family of ligands and receptors in renal development, physiology and pathophysiology. Exp Cell Res. 315:602–610. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Cohen D, Lane B, Jin T, Magi-Galluzzi C, Finke J, Rini BI, Bukowski RM and Zhou M: The prognostic significance of epidermal growth factor receptor expressionin Clear-cell renal cell carcinoma: A call for standardized methods for immunohistochemical evaluation. Clin Genitourinary Cancer. 5:264–270. 2007. View Article : Google Scholar

24 

Kallio JP, Hirvikoski P, Helin H, Kellokumpu-Lehtinen P, Luukkaala T, Tammela TL and Martikainen PM: Membranous location of EGFR immunostaining is associated with good prognosis in renal cell carcinoma. Br J Cancer. 89:1266–1269. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Kankaya D, Kiremitci S, Tulunay O and Baltaci S: Prognostic impact of epidermal growth factor receptor on clear cell renal cell carcinoma: Does it change with different expression patterns? Indian J Pathol Microbiol. 59:35–40. 2016.PubMed/NCBI

26 

Merseburger AS, Hennenlotter J, Simon P, Kruck S, Koch E, Horstmann M, Kuehs U, Küfer R, Stenzl A and Kuczyk MA: Membranous expression and prognostic implications of epidermal growth factor receptor protein in human renal cell cancer. Anticancer Res. 25:1901–1907. 2005.PubMed/NCBI

27 

Mock H, Sauter G, Buchholz N, Gasser TC, Bubendorf L, Waldman FM and Mihatsch MJ: Epidermal growth factor receptor expression is associated with rapid tumor cell proliferation in renal cell carcinoma. Hum Pathol. 28:1255–1259. 1997. View Article : Google Scholar : PubMed/NCBI

28 

Pu YS, Huang CY, Kuo YZ, Kang WY, Liu GY, Huang AM, Yu HJ, Lai MK, Huang SP, Wu WJ, et al: Characterization of membranous and cytoplasmic EGFR expression in human normal renal cortex and renal cell carcinoma. J Biomed Sci. 16:82. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Athar M and Iqbal M: Ferric nitrilotriacetate promotes N-diethylnitrosamine-induced renal tumorigenesis in the rat: Implications for the involvement of oxidative stress. Carcinogenesis. 19:1133–1139. 1998. View Article : Google Scholar : PubMed/NCBI

30 

Ebina Y, Okada S, Hamazaki S, Ogino F, Li JL and Midorikawa O: Nephrotoxicity and renal cell carcinoma after use of Iron- and aluminum-nitrilotriacetate complexes in Rats2. J Natl Cancer Inst. 76:107–113. 1986.PubMed/NCBI

31 

Jahangir T and Sultana S: Modulatory effects of shape pluchea lanceolata against chemically induced oxidative damage, hyperproliferation and Two-stage renal carcinogenesis in wistar rats. Mol Cell Biochem. 291:175–185. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Mendoza-Rodrıguez CA, Monroy-Mendoza MG, Morimoto S and Cerbón MA: Pro-apoptotic signals of the bcl-2 gene family in the rat uterus occurs in the night before the day of estrus and precedes ovulation. Mol Cell Endocrinol. 208:31–39. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Schneider CA, Rasband WS and Eliceiri KW: NIH image to ImageJ: 25 years of image analysis. Nat Methods. 9:671–675. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Ledeganck KJ, Boulet GA, Horvath CA, Vinckx M, Bogers JJ, Van Den Bossche R, Verpooten GA and De Winter BY: Expression of renal distal tubule transporters TRPM6 and NCC in a rat model of cyclosporine nephrotoxicity and effect of EGF treatment. Am J Physiol Renal Physiol. 301:F486–F493. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Cai FG, Xiao JS and Ye QF: Effects of ischemic preconditioning on cyclinD1 expression during early ischemic reperfusion in rats. World J Gastroenterol. 12:2936–2940. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Rehman MU, Tahir M, Khan AQ, Khan R, Lateef A, Oday OH, Qamar W, Ali F and Sultana S: Chrysin suppresses renal carcinogenesis via amelioration of hyperproliferation, oxidative stress and inflammation: Plausible role of NF-κB. Toxicol Lett. 216:146–158. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Siddiqi A, Hasan SK, Nafees S, Rashid S, Saidullah B and Sultana S: Chemopreventive efficacy of hesperidin against chemically induced nephrotoxicity and renal carcinogenesis via amelioration of oxidative stress and modulation of multiple molecular pathways. Exp Mol Pathol. 99:641–653. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Christian F, Smith EL and Carmody RJ: The regulation of NF-κB subunits by phosphorylation. Cells. 5(pii): E122016. View Article : Google Scholar : PubMed/NCBI

39 

Perkins ND: Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway. Oncogene. 25:6717–6730. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Espinosa L, Bigas A and Mulero MC: Novel functions of chromatin-bound IκBα in oncogenic transformation. Br J Cancer. 111:1688–1692. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Cantile M, Schiavo G, Franco R, Cindolo L, Procino A, D'Armiento M, Facchini G, Terracciano L, Botti G and Cillo C: Expression of lumbosacral HOX genes, crucial in kidney organogenesis, is systematically deregulated in clear cell kidney cancers. Anticancer Drugs. 22:392–401. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Mulero MC, Ferres-Marco D, Islam A, Margalef P, Pecoraro M, Toll A, Drechsel N, Charneco C, Davis S, Bellora N, et al: Chromatin-bound IκBα regulates a subset of polycomb target genes in differentiation and cancer. Cancer Cell. 24:151–166. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Morotti A, Crivellaro S, Panuzzo C, Carrà G, Guerrasio A and Saglio G: IκB-α: At the crossroad between oncogenic and tumor-suppressive signals. Oncol Lett. 13:531–534. 2017. View Article : Google Scholar : PubMed/NCBI

44 

Okada K, Wangpoengtrakul C, Osawa T, Toyokuni S, Tanaka K and Uchida K: 4-Hydroxy-2-nonenal-mediated impairment of intracellular proteolysis during Oxidative Stress: Identification of proteasomes as target molecules. J Biol Chem. 274:23787–23793. 1999. View Article : Google Scholar : PubMed/NCBI

45 

Zhou L and Yang H: The von Hippel-lindau tumor suppressor protein promotes c-Cbl-independent poly-ubiquitylation and degradation of the activated EGFR. PLoS One. 6:e239362011. View Article : Google Scholar : PubMed/NCBI

46 

Johnson AC, Murphy BA, Matelis CM, Rubinstein Y, Piebenga EC, Akers LM, Neta G, Vinson C and Birrer M: Activator protein-1 mediates induced but not basal epidermal growth factor receptor gene expression. Mol Med. 6:17–27. 2000. View Article : Google Scholar : PubMed/NCBI

47 

Brand TM, Iida M, Luthar N, Starr MM, Huppert EJ and Wheeler DL: Nuclear EGFR as a molecular target in cancer. Radiother Oncol. 108:370–377. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Sharmila R and Sindhu G: Evaluate the antigenotoxicity and anticancer role of β-sitosterol by determining oxidative DNA damage and the expression of phosphorylated Mitogen-activated Protein Kinases', C-fos, C-jun, and endothelial growth factor receptor. Pharmacogn Mag. 13:95–101. 2017.PubMed/NCBI

49 

Bandyopadhyay D, Mandal M, Adam L, Mendelsohn J and Kumar R: Physical Interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells. J Biol Chem. 273:1568–1573. 1998. View Article : Google Scholar : PubMed/NCBI

50 

Goodwin JF and Knudsen KE: Beyond DNA repair: DNA-PK function in cancer. Cancer Discov. 4:1126–1139. 2014. View Article : Google Scholar : PubMed/NCBI

51 

Liccardi G, Hartley JA and Hochhauser D: EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatment. Cancer Res. 71:1103–1114. 2011. View Article : Google Scholar : PubMed/NCBI

52 

Toyokuni S, Mori T and Dizdaroglu M: DNA base modifications in renal chromatin of wistar rats treated with a renal carcinogen, ferric nitrilotriacetate. Int J Cancer. 57:123–128. 1994. View Article : Google Scholar : PubMed/NCBI

53 

Ansar S, Iqbal M and Athar M: Nordihydroguairetic acid is a potent inhibitor of ferric-nitrilotriacetate-mediated hepatic and renal toxicity, and renal tumour promotion, in mice. Carcinogenesis. 20:599–606. 1999. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Pariente‑Pérez T, Aguilar‑Alonso F, Solano JD, Vargas‑Olvera C, Curiel‑Muñiz P, Mendoza‑Rodríguez CA, Tenorio‑Hernández D and Ibarra‑Rubio ME: Differential behavior of NF‑κB, IκBα and EGFR during the renal carcinogenic process in an experimental model in vivo. Oncol Lett 19: 3153-3164, 2020.
APA
Pariente‑Pérez, T., Aguilar‑Alonso, F., Solano, J.D., Vargas‑Olvera, C., Curiel‑Muñiz, P., Mendoza‑Rodríguez, C.A. ... Ibarra‑Rubio, M.E. (2020). Differential behavior of NF‑κB, IκBα and EGFR during the renal carcinogenic process in an experimental model in vivo. Oncology Letters, 19, 3153-3164. https://doi.org/10.3892/ol.2020.11436
MLA
Pariente‑Pérez, T., Aguilar‑Alonso, F., Solano, J. D., Vargas‑Olvera, C., Curiel‑Muñiz, P., Mendoza‑Rodríguez, C. A., Tenorio‑Hernández, D., Ibarra‑Rubio, M. E."Differential behavior of NF‑κB, IκBα and EGFR during the renal carcinogenic process in an experimental model in vivo". Oncology Letters 19.4 (2020): 3153-3164.
Chicago
Pariente‑Pérez, T., Aguilar‑Alonso, F., Solano, J. D., Vargas‑Olvera, C., Curiel‑Muñiz, P., Mendoza‑Rodríguez, C. A., Tenorio‑Hernández, D., Ibarra‑Rubio, M. E."Differential behavior of NF‑κB, IκBα and EGFR during the renal carcinogenic process in an experimental model in vivo". Oncology Letters 19, no. 4 (2020): 3153-3164. https://doi.org/10.3892/ol.2020.11436
Copy and paste a formatted citation
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Spandidos Publications style
Pariente‑Pérez T, Aguilar‑Alonso F, Solano JD, Vargas‑Olvera C, Curiel‑Muñiz P, Mendoza‑Rodríguez CA, Tenorio‑Hernández D and Ibarra‑Rubio ME: Differential behavior of NF‑κB, IκBα and EGFR during the renal carcinogenic process in an experimental model in vivo. Oncol Lett 19: 3153-3164, 2020.
APA
Pariente‑Pérez, T., Aguilar‑Alonso, F., Solano, J.D., Vargas‑Olvera, C., Curiel‑Muñiz, P., Mendoza‑Rodríguez, C.A. ... Ibarra‑Rubio, M.E. (2020). Differential behavior of NF‑κB, IκBα and EGFR during the renal carcinogenic process in an experimental model in vivo. Oncology Letters, 19, 3153-3164. https://doi.org/10.3892/ol.2020.11436
MLA
Pariente‑Pérez, T., Aguilar‑Alonso, F., Solano, J. D., Vargas‑Olvera, C., Curiel‑Muñiz, P., Mendoza‑Rodríguez, C. A., Tenorio‑Hernández, D., Ibarra‑Rubio, M. E."Differential behavior of NF‑κB, IκBα and EGFR during the renal carcinogenic process in an experimental model in vivo". Oncology Letters 19.4 (2020): 3153-3164.
Chicago
Pariente‑Pérez, T., Aguilar‑Alonso, F., Solano, J. D., Vargas‑Olvera, C., Curiel‑Muñiz, P., Mendoza‑Rodríguez, C. A., Tenorio‑Hernández, D., Ibarra‑Rubio, M. E."Differential behavior of NF‑κB, IκBα and EGFR during the renal carcinogenic process in an experimental model in vivo". Oncology Letters 19, no. 4 (2020): 3153-3164. https://doi.org/10.3892/ol.2020.11436
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