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Review Open Access

Association of oral dysbiosis with oral cancer development (Review)

  • Authors:
    • Giusy Rita Maria La Rosa
    • Giuseppe Gattuso
    • Eugenio Pedullà
    • Ernesto Rapisarda
    • Daria Nicolosi
    • Mario Salmeri
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery and Surgical-Medical Specialties, University of Catania, I-95125 Catania, Italy, Department of Biomedical and Biotechnological Sciences, International PhD Program in Basic and Applied Biomedical Sciences, University of Catania, I-95123 Catania, Italy, Department of Biomedical and Biotechnological Sciences, University of Catania, I-95123 Catania, Italy
    Copyright: © La Rosa et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Pages: 3045-3058
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    Published online on: March 3, 2020
       https://doi.org/10.3892/ol.2020.11441
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Abstract

Oral squamous cell carcinoma (OSCC) is the leading cause of mortality for oral cancer. Numerous risk factors mainly related to unhealthy habits and responsible for chronic inflammation and infections have been recognized as predisposing factors for oral carcinogenesis. Recently, even microbiota alterations have been associated with the development of human cancers. In particular, some specific bacterial strains have been recognized and strongly associated with oral cancer development (Capnocytophaga gingivalis, Fusobacterium spp., Streptococcus spp., Peptostreptococcus spp., Porphyromonas gingivalis and Prevotella spp.). Several hypotheses have been proposed to explain how the oral microbiota could be involved in cancer pathogenesis by mainly paying attention to chronic inflammation, microbial synthesis of cancerogenic substances, and alteration of epithelial barrier integrity. Based on knowledge of the carcinogenic effects of dysbiosis, it was recently suggested that probiotics may have anti-tumoral activity. Nevertheless, few data exist with regard to probiotic effects on oral cancer. On this basis, the association between the development of oral cancer and oral dysbiosis is discussed focusing attention on the potential benefits of probiotics administration in cancer prevention.
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Copy and paste a formatted citation
Spandidos Publications style
La Rosa GR, Gattuso G, Pedullà E, Rapisarda E, Nicolosi D and Salmeri M: Association of oral dysbiosis with oral cancer development (Review). Oncol Lett 19: 3045-3058, 2020.
APA
La Rosa, G.R., Gattuso, G., Pedullà, E., Rapisarda, E., Nicolosi, D., & Salmeri, M. (2020). Association of oral dysbiosis with oral cancer development (Review). Oncology Letters, 19, 3045-3058. https://doi.org/10.3892/ol.2020.11441
MLA
La Rosa, G. R., Gattuso, G., Pedullà, E., Rapisarda, E., Nicolosi, D., Salmeri, M."Association of oral dysbiosis with oral cancer development (Review)". Oncology Letters 19.4 (2020): 3045-3058.
Chicago
La Rosa, G. R., Gattuso, G., Pedullà, E., Rapisarda, E., Nicolosi, D., Salmeri, M."Association of oral dysbiosis with oral cancer development (Review)". Oncology Letters 19, no. 4 (2020): 3045-3058. https://doi.org/10.3892/ol.2020.11441
Copy and paste a formatted citation
x
Spandidos Publications style
La Rosa GR, Gattuso G, Pedullà E, Rapisarda E, Nicolosi D and Salmeri M: Association of oral dysbiosis with oral cancer development (Review). Oncol Lett 19: 3045-3058, 2020.
APA
La Rosa, G.R., Gattuso, G., Pedullà, E., Rapisarda, E., Nicolosi, D., & Salmeri, M. (2020). Association of oral dysbiosis with oral cancer development (Review). Oncology Letters, 19, 3045-3058. https://doi.org/10.3892/ol.2020.11441
MLA
La Rosa, G. R., Gattuso, G., Pedullà, E., Rapisarda, E., Nicolosi, D., Salmeri, M."Association of oral dysbiosis with oral cancer development (Review)". Oncology Letters 19.4 (2020): 3045-3058.
Chicago
La Rosa, G. R., Gattuso, G., Pedullà, E., Rapisarda, E., Nicolosi, D., Salmeri, M."Association of oral dysbiosis with oral cancer development (Review)". Oncology Letters 19, no. 4 (2020): 3045-3058. https://doi.org/10.3892/ol.2020.11441
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