Open Access

Autophagy suppresses resveratrol‑induced apoptosis in renal cell carcinoma 786‑O cells

  • Authors:
    • Hongwei Yao
    • Min Fan
    • Xiaozhou He
  • View Affiliations

  • Published online on: March 3, 2020     https://doi.org/10.3892/ol.2020.11442
  • Pages: 3269-3277
  • Copyright: © Yao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

As a polyphenolic compound, resveratrol (Res) is widely distributed in a variety of plants. Previous studies have demonstrated that Res can inhibit various different types of tumor growth. However, its role in renal cell carcinoma (RCC) remains largely unknown. The present study first demonstrated that Res inhibited cell viability and induced apoptosis in RCC 786‑O cells. Further experiments revealed that Res damaged the mitochondria and activated caspase 3. In contrast, Z‑VAD‑FMK, a pan‑caspase inhibitor, suppressed Res‑induced apoptosis. Reactive oxygen species (ROS) were involved in the process of Res‑induced apoptosis, and antioxidant N‑acetyl cysteine could significantly attenuate this. Furthermore, Res activated c‑Jun N‑terminal kinase via ROS to induce autophagy, whereas inhibition of autophagy with chloroquine or Beclin 1 small interfering RNA aggravated Res‑induced apoptosis, indicating that autophagy served as a pro‑survival mechanism to protect 786‑O cells from Res‑induced apoptosis. Therefore, a combination of Res and autophagy inhibitors could enhance the inhibitory effect of Res on RCC.
View Figures
View References

Related Articles

Journal Cover

April-2020
Volume 19 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Yao H, Fan M and He X: Autophagy suppresses resveratrol‑induced apoptosis in renal cell carcinoma 786‑O cells. Oncol Lett 19: 3269-3277, 2020
APA
Yao, H., Fan, M., & He, X. (2020). Autophagy suppresses resveratrol‑induced apoptosis in renal cell carcinoma 786‑O cells. Oncology Letters, 19, 3269-3277. https://doi.org/10.3892/ol.2020.11442
MLA
Yao, H., Fan, M., He, X."Autophagy suppresses resveratrol‑induced apoptosis in renal cell carcinoma 786‑O cells". Oncology Letters 19.4 (2020): 3269-3277.
Chicago
Yao, H., Fan, M., He, X."Autophagy suppresses resveratrol‑induced apoptosis in renal cell carcinoma 786‑O cells". Oncology Letters 19, no. 4 (2020): 3269-3277. https://doi.org/10.3892/ol.2020.11442