Open Access

Ototoxicity after platinum‑based chemotherapy in the treatment of melanotic neuroectodermal tumour of infancy

  • Authors:
    • Dorota Hojan‑Jezierska
    • Anna Chomiak
    • Agata Czopor
    • Maja Matthews‑Kozanecka
    • Anna Majewska
    • Marta Urbaniak‑Olejnik
    • Teresa Matthews‑Brzozowska
  • View Affiliations

  • Published online on: March 5, 2020     https://doi.org/10.3892/ol.2020.11447
  • Pages: 3411-3416
  • Copyright: © Hojan‑Jezierska et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Melanotic neuroectodermal tumor of infancy (MNTI) is a rare infantile tumor that originates from mesenchymal‑neuroectodermal cells, the treatment of which uses platinum derivatives that can affect hearing loss. The present study evaluated the long‑term effects of ototoxicity following chemotherapy with cisplatin, vincristine, cyclophosphamide, teniposide and adriamycin in a 10‑year‑old patient after surgical removal of a MNTI tumor at the age of 8 months. Audiometric tests (high‑frequency tonal audiometry, speech audiometry, speech acoustics, tympanometry and absorbance measurements) were performed during a 10‑year follow‑up after receiving chemotherapy. Hearing disorders in the high‑frequency range (6,000 to 16,000 Hz range) were demonstrated for both ears, indicating that these may be the long‑term effects of chemotherapy with use of platinum compounds during the treatment of infants.

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May 2020
Volume 19 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Hojan‑Jezierska, D., Chomiak, A., Czopor, A., Matthews‑Kozanecka, M., Majewska, A., Urbaniak‑Olejnik, M., & Matthews‑Brzozowska, T. (2020). Ototoxicity after platinum‑based chemotherapy in the treatment of melanotic neuroectodermal tumour of infancy. Oncology Letters, 19, 3411-3416. https://doi.org/10.3892/ol.2020.11447
MLA
Hojan‑Jezierska, D., Chomiak, A., Czopor, A., Matthews‑Kozanecka, M., Majewska, A., Urbaniak‑Olejnik, M., Matthews‑Brzozowska, T."Ototoxicity after platinum‑based chemotherapy in the treatment of melanotic neuroectodermal tumour of infancy". Oncology Letters 19.5 (2020): 3411-3416.
Chicago
Hojan‑Jezierska, D., Chomiak, A., Czopor, A., Matthews‑Kozanecka, M., Majewska, A., Urbaniak‑Olejnik, M., Matthews‑Brzozowska, T."Ototoxicity after platinum‑based chemotherapy in the treatment of melanotic neuroectodermal tumour of infancy". Oncology Letters 19, no. 5 (2020): 3411-3416. https://doi.org/10.3892/ol.2020.11447