Open Access

Exosomal circular RNA sorting mechanisms and their function in promoting or inhibiting cancer (Review)

  • Authors:
    • Xiuchao Geng
    • Xiaomeng Lin
    • Yuhao Zhang
    • Qiang Li
    • Yajing Guo
    • Chuan Fang
    • Hong Wang
  • View Affiliations

  • Published online on: March 6, 2020     https://doi.org/10.3892/ol.2020.11449
  • Pages: 3369-3380
  • Copyright: © Geng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Exosomes are nanoscale phospholipid bilayer vesicles that can be artificially engineered into vectors for the treatment of cancer. Circular RNA (circRNA), a type of non‑coding RNA, has crucial regulatory functions in various aspects of cancer, such as tumorigenesis, apoptosis, proliferation, invasion, metastasis and chemo‑ and radiotherapeutic resistance, as well as in cancer prognosis. Notably, the exosomal transfer of circRNAs may function to both promote and inhibit cancer. Numerous studies have addressed the importance of circRNAs in cancer and non‑coding RNAs (such as microRNAs and long non‑coding RNAs) in exosomes. However, little research has focussed on a class of RNAs called exosomal circRNAs. The present review discusses current studies regarding exosomal circRNAs, including their biogenesis and biological functions, their abundance in exosomes and possible sorting mechanisms and their potential roles in both promoting and inhibiting cancer. It is predicted that in the next five years there will be increasing research exploring the functional mechanisms of exosomal circRNA in various diseases, in particular their roles in cancer genesis and progression.

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May 2020
Volume 19 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Geng, X., Lin, X., Zhang, Y., Li, Q., Guo, Y., Fang, C., & Wang, H. (2020). Exosomal circular RNA sorting mechanisms and their function in promoting or inhibiting cancer (Review). Oncology Letters, 19, 3369-3380. https://doi.org/10.3892/ol.2020.11449
MLA
Geng, X., Lin, X., Zhang, Y., Li, Q., Guo, Y., Fang, C., Wang, H."Exosomal circular RNA sorting mechanisms and their function in promoting or inhibiting cancer (Review)". Oncology Letters 19.5 (2020): 3369-3380.
Chicago
Geng, X., Lin, X., Zhang, Y., Li, Q., Guo, Y., Fang, C., Wang, H."Exosomal circular RNA sorting mechanisms and their function in promoting or inhibiting cancer (Review)". Oncology Letters 19, no. 5 (2020): 3369-3380. https://doi.org/10.3892/ol.2020.11449