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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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Case Report

Imatinib therapy in acute myeloid leukemia with DEK‑NUP214 and FIP1L1‑PDGFRA rearrangement: A case report

  • Authors:
    • Yanping Yang
    • Hai Lin
    • Zhonghua Du
    • Ruiping Hu
    • Yang Tang
    • Xinyue Liang
    • Jingnan Sun
    • Yehui Tan
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, First Bethune Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
  • Pages: 3587-3592
    |
    Published online on: March 10, 2020
       https://doi.org/10.3892/ol.2020.11455
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Abstract

The fusion product of FIP1‑like‑1 (FIP1L1) and platelet‑derived growth factor receptor α (PDGFRA) gene rearrangement is a tyrosine kinase oncoprotein sensitive to imatinib. This gene rearrangement characterizes a novel clinico‑biological class of myeloid and lymphoid neoplasms with eosinophilia and PDGFRA abnormalities. The DEK proto‑oncogene (DEK) and nucleoporin 214 (NUP214) rearrangement is rare in patients with acute myeloid leukemia (AML); therefore, the coexistence of DEK‑NUP214 and FIP1L1‑PDGFRA rearrangements in patients with AML is extremely rare. The present study presents a rare relapse case of a patient with AML with DEK‑NUP214 and FIP1L1‑PDGFRA rearrangements, without marked eosinophilia in the peripheral blood or bone marrow. Low‑dose imatinib monotherapy without intensive chemotherapy was used to achieve complete hematological remission.
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Copy and paste a formatted citation
Spandidos Publications style
Yang Y, Lin H, Du Z, Hu R, Tang Y, Liang X, Sun J and Tan Y: Imatinib therapy in acute myeloid leukemia with DEK‑NUP214 and FIP1L1‑PDGFRA rearrangement: A case report. Oncol Lett 19: 3587-3592, 2020.
APA
Yang, Y., Lin, H., Du, Z., Hu, R., Tang, Y., Liang, X. ... Tan, Y. (2020). Imatinib therapy in acute myeloid leukemia with DEK‑NUP214 and FIP1L1‑PDGFRA rearrangement: A case report. Oncology Letters, 19, 3587-3592. https://doi.org/10.3892/ol.2020.11455
MLA
Yang, Y., Lin, H., Du, Z., Hu, R., Tang, Y., Liang, X., Sun, J., Tan, Y."Imatinib therapy in acute myeloid leukemia with DEK‑NUP214 and FIP1L1‑PDGFRA rearrangement: A case report". Oncology Letters 19.5 (2020): 3587-3592.
Chicago
Yang, Y., Lin, H., Du, Z., Hu, R., Tang, Y., Liang, X., Sun, J., Tan, Y."Imatinib therapy in acute myeloid leukemia with DEK‑NUP214 and FIP1L1‑PDGFRA rearrangement: A case report". Oncology Letters 19, no. 5 (2020): 3587-3592. https://doi.org/10.3892/ol.2020.11455
Copy and paste a formatted citation
x
Spandidos Publications style
Yang Y, Lin H, Du Z, Hu R, Tang Y, Liang X, Sun J and Tan Y: Imatinib therapy in acute myeloid leukemia with DEK‑NUP214 and FIP1L1‑PDGFRA rearrangement: A case report. Oncol Lett 19: 3587-3592, 2020.
APA
Yang, Y., Lin, H., Du, Z., Hu, R., Tang, Y., Liang, X. ... Tan, Y. (2020). Imatinib therapy in acute myeloid leukemia with DEK‑NUP214 and FIP1L1‑PDGFRA rearrangement: A case report. Oncology Letters, 19, 3587-3592. https://doi.org/10.3892/ol.2020.11455
MLA
Yang, Y., Lin, H., Du, Z., Hu, R., Tang, Y., Liang, X., Sun, J., Tan, Y."Imatinib therapy in acute myeloid leukemia with DEK‑NUP214 and FIP1L1‑PDGFRA rearrangement: A case report". Oncology Letters 19.5 (2020): 3587-3592.
Chicago
Yang, Y., Lin, H., Du, Z., Hu, R., Tang, Y., Liang, X., Sun, J., Tan, Y."Imatinib therapy in acute myeloid leukemia with DEK‑NUP214 and FIP1L1‑PDGFRA rearrangement: A case report". Oncology Letters 19, no. 5 (2020): 3587-3592. https://doi.org/10.3892/ol.2020.11455
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