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Clinical and prognostic significance of MYH11 in lung cancer

  • Authors:
    • Meng‑Jun Nie
    • Xiao‑Ting Pan
    • He‑Yun Tao
    • Meng‑Jun Xu
    • Shen‑Lin Liu
    • Wei Sun
    • Jian Wu
    • Xi Zou
  • View Affiliations / Copyright

    Affiliations: Oncology Department, The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China
    Copyright: © Nie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3899-3906
    |
    Published online on: March 27, 2020
       https://doi.org/10.3892/ol.2020.11478
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Abstract

Myosin heavy chain 11 (MYH11), encoded by the MYH11 gene, is a protein that participates in muscle contraction through the hydrolysis of adenosine triphosphate. Although previous studies have demonstrated that MYH11 gene expression levels are downregulated in several types of cancer, its expression levels have rarely been investigated in lung cancer. The present study aimed to explore the clinical significance and prognostic value of MYH11 expression levels in lung cancer and to further study the underlying molecular mechanisms of the function of this gene. The Oncomine database showed that the MYH11 expression levels were decreased in lung cancer compared with those noted in the normal lung tissue (P<0.05). Kaplan‑Meier plotter results revealed that the decreased MYH11 expression levels were correlated with poor prognosis in lung cancer patients. Among the lung cancer cases with gene alteration of MYH11, mutation was the most common of all alteration types. Coexpedia and Metascape analyses revealed that the target genes were primarily enriched in ‘muscle contraction’, ‘contractile fiber part’, ‘actin cytoskeleton’ and the ‘adherens junction’. These results indicated that MYH11 is a potential novel drug target and prognostic indicator of lung cancer.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Matsuoka R, Yoshida MC, Furutani Y, Imamura S, Kanda N, Yanagisawa M, Masaki T and Takao A: Human smooth muscle myosin heavy chain gene mapped to chromosomal region 16q12. Am J Med Genet. 46:61–67. 1993. View Article : Google Scholar : PubMed/NCBI

4 

Huxley AF and Niedergerke R: Structural changes in muscle during contraction: Interference microscopy of living muscle fibres. Nature. 173:971–973. 1954. View Article : Google Scholar : PubMed/NCBI

5 

Huxley H and Hanson J: Changes in the cross-striations of muscle during contraction and stretch and their structural interpretation. Nature. 173:973–976. 1954. View Article : Google Scholar : PubMed/NCBI

6 

Zhu L, Vranckx R, Khau Van Kien P, Lalande A, Boisset N, Mathieu F, Wegman M, Glancy L, Gasc JM, Brunotte F, et al: Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus. Nat Genet. 38:343–349. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Pannu H, Tran-Fadulu V, Papke CL, Scherer S, Liu Y, Presley C, Guo D, Estrera AL, Safi HJ, Brasier AR, et al: MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II. Hum Mol Genet. 16:2453–2462. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Xi WD, Liu YJ, Sun XB, Shan J, Yi L and Zhang TT: Bioinformatics analysis of RNA-seq data revealed critical genes in colon adenocarcinoma. Eur Rev Med Pharmacol Sci. 21:3012–3020. 2017.PubMed/NCBI

9 

Wang RJ, Wu P, Cai GX, Wang ZM, Xu Y, Peng JJ, Sheng WQ, Lu HF and Cai SJ: Down-regulated MYH11 expression correlates with poor prognosis in stage II and III colorectal cancer. Asian Pac J Cancer Prev. 15:7223–7228. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Hu J, Zhou L, Song Z, Xiong M, Zhang Y, Yang Y, Chen K and Chen Z: The identification of new biomarkers for bladder cancer: A study based on TCGA and GEO datasets. J Cell Physiol. Feb 18–2019.(Epub ahead of print). View Article : Google Scholar

11 

Su J, Zhang Y, Su H, Zhang C and Li W: A recurrence model for laryngeal cancer based on SVM and gene function clustering. Acta Otolaryngol. 137:557–562. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Islam T, Rahman R, Gov E, Turanli B, Gulfidan G, Haque A, Arga KY and Haque Mollah N: Drug targeting and biomarkers in head and neck cancers: Insights from systems biology analyses. OMICS. 22:422–436. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Krendel M and Mooseker MS: Myosins: Tails (and Heads) of functional diversity. Physiology (Bethesda). 20:239–251. 2005.PubMed/NCBI

14 

Pollard TD and Weihing RR: Actin and myosin and cell movemen. CRC Crit Rev Biochem. 2:1–65. 2008. View Article : Google Scholar

15 

Ma Q, Xu Y, Liao H, Cai Y, Xu L, Xiao D, Liu C, Pu W, Zhong X and Guo X: Identification and validation of key genes associated with non-small-cell lung cancer. J Cell Physiol. 234:22742–22752. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Findeisen P, Röckel M, Nees M, Röder C, Kienle P, Von Knebel Doeberitz M, Kalthoff H and Neumaier M: Systematic identification and validation of candidate genes for detection of circulating tumor cells in peripheral blood specimens of colorectal cancer patients. Int J Oncol. 33:1001–1010. 2008.PubMed/NCBI

17 

Rhodes DR, Kalyana-Sundaram S, Mahavisno V, Varambally R, Yu J, Briggs BB, Barrette TR, Anstet MJ, Kincead-Beal C, et al: Oncomine 3. 0: Genes, pathways, and networks in a collection of 18, 000 cancer gene expression profiles. Neoplasia. 9:166–180. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Nagy A, Lánczky A, Menyhárt O and Győrffy B: Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets. Sci Rep. 8:92272018. View Article : Google Scholar : PubMed/NCBI

19 

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI

20 

Yang S, Kim CY, Hwang S, Kim E, Kim H, Shim H and Lee I: COEXPEDIA: Exploring biomedical hypotheses via co-expressions associated with medical subject headings (MeSH). Nucleic Acids Res. 45:D389–D936. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Bhattacharjee A, Richards WG, Staunton J, Li C, Monti S, Vasa P, Ladd C, Beheshti J, Bueno R, Gillette M, et al: Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc Natl Acad Sci USA. 98:13790–13795. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Beer DG, Kardia SL, Huang CC, Giordano TJ, Levin AM, Misek DE, Lin L, Chen G, Gharib TG, Thomas DG, et al: Gene-expression profiles predict survival of patients with lung adenocarcinoma. Nat Med. 8:816–824. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Landi MT, Dracheva T, Rotunno M, Figueroa JD, Liu H, Dasgupta A, Mann FE, Fukuoka J, Hames M, Bergen AW, et al: Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival. PLoS One. 3:e16512008. View Article : Google Scholar : PubMed/NCBI

25 

Stearman RS, Dwyer-Nield L, Zerbe L, Blaine SA, Chan Z, Bunn PA Jr, Johnson GL, Hirsch FR, Merrick DT, Franklin WA, et al: Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model. Am J Pathol. 167:1763–1775. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Talbot SG, Estilo C, Maghami E, Sarkaria IS, Pham DK, O-charoenrat P, Socci ND, Ngai I, Carlson D, Ghossein R, et al: Gene expression profiling allows distinction between primary and metastatic squamous cell carcinomas in the lung. Cancer Res. 65:3063–3071. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Hou J, Aerts J, den Hamer B, van Ijcken W, den Bakker M, Riegman P, van der Leest C, van der Spek P, Foekens JA, Hoogsteden HC, et al: Gene expression-based classification of non-small cell lung carcinomas and survival prediction. PLoS One. 5:e103122010. View Article : Google Scholar : PubMed/NCBI

28 

Su LJ, Chang CW, Wu YC, Chen KC, Lin CJ, Liang SC, Lin CH, Whang-Peng J, Hsu SL, Chen CH and Huang CY: Selection of DDX5 as a novel internal control for Q-RT- PCR from microarray data using a block bootstrap re-sampling scheme. BMC Genomics. 8:1402007. View Article : Google Scholar : PubMed/NCBI

29 

Selamat SA, Chung BS, Girard L, Zhang W, Zhang Y, Campan M, Siegmund KD, Koss MN, Hagen JA, Lam WL, et al: Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression. Genome Res. 22:1197–1211. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Okayama H, Kohno T, Ishii Y, Shimada Y, Shiraishi K, Iwakawa R, Furuta K, Tsuta K, Shibata T, Yamamoto S, et al: Identification of genes upregulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas. Cancer Res. 72:100–111. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Alhopuro P, Karhu A, Winqvist R, Waltering K, Visakorpi T and Aaltonen LA: Somatic mutation analysis of MYH11 in breast and prostate cancer. BMC Cancer. 8:2632008. View Article : Google Scholar : PubMed/NCBI

32 

Deng Z, Liu P, Marlton P, Claxton DF, Lane S, Callen DF, Collins FS and Siciliano MJ: Smooth muscle myosin heavy chain locus (MYH11) maps to 16p13.13-p13.12 and establishes a new region of conserved synteny between human 16p and mouse 16. Genomics. 18:156–159. 1993. View Article : Google Scholar : PubMed/NCBI

33 

Trybus KM: Regulation of smooth muscle myosin. Cell Motil Cytoskeleton. 18:81–85. 1991. View Article : Google Scholar : PubMed/NCBI

34 

Issouf M, Vargas A, Boivin R and Lavoie JP: SRSF6 is upregulated in asthmatic horses and involved in the MYH11 SMB expression. Physiol Rep. 6:e138962018. View Article : Google Scholar : PubMed/NCBI

35 

Goyama S and Mulloy JC: Molecular pathogenesis of core binding factor leukemia: Current knowledge and future prospects. Int J Hematol. 94:126–133. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Liu P, Tarlé SA, Hajra A, Claxton DF, Marlton P, Freedman M, Siciliano MJ and Collins FS: Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia. Science. 261:1041–1044. 1993. View Article : Google Scholar : PubMed/NCBI

37 

Ning X and Deng Y: Identification of key pathways and genes influencing prognosis in bladder urothelial carcinoma. Onco Targets Ther. 10:1673–1686. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Seitz S, Korsching E, Weimer J, Jacobsen A, Arnold N, Meindl A, Arnold W, Gustavus D, Klebig C, Petersen I and Scherneck S: Genetic background of different cancer cell lines influences the gene set involved in chromosome 8 mediated breast tumor suppression. Genes Chromosomes Cancer. 45:612–627. 2010. View Article : Google Scholar

39 

Alhopuro P, Phichith D, Tuupanen S, Sammalkorpi H, Nybondas M, Saharinen J, Robinson JP, Yang Z, Chen LQ, Orntoft T, et al: Unregulated smooth-muscle myosin in human intestinal neoplasia. Proc Natl Acad Sci USA. 105:5513–5518. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Nie MJ, Pan XT, Tao HY, Xu MJ, Liu SL, Sun W, Wu J and Zou X: Clinical and prognostic significance of MYH11 in lung cancer. Oncol Lett 19: 3899-3906, 2020.
APA
Nie, M., Pan, X., Tao, H., Xu, M., Liu, S., Sun, W. ... Zou, X. (2020). Clinical and prognostic significance of MYH11 in lung cancer. Oncology Letters, 19, 3899-3906. https://doi.org/10.3892/ol.2020.11478
MLA
Nie, M., Pan, X., Tao, H., Xu, M., Liu, S., Sun, W., Wu, J., Zou, X."Clinical and prognostic significance of MYH11 in lung cancer". Oncology Letters 19.6 (2020): 3899-3906.
Chicago
Nie, M., Pan, X., Tao, H., Xu, M., Liu, S., Sun, W., Wu, J., Zou, X."Clinical and prognostic significance of MYH11 in lung cancer". Oncology Letters 19, no. 6 (2020): 3899-3906. https://doi.org/10.3892/ol.2020.11478
Copy and paste a formatted citation
x
Spandidos Publications style
Nie MJ, Pan XT, Tao HY, Xu MJ, Liu SL, Sun W, Wu J and Zou X: Clinical and prognostic significance of MYH11 in lung cancer. Oncol Lett 19: 3899-3906, 2020.
APA
Nie, M., Pan, X., Tao, H., Xu, M., Liu, S., Sun, W. ... Zou, X. (2020). Clinical and prognostic significance of MYH11 in lung cancer. Oncology Letters, 19, 3899-3906. https://doi.org/10.3892/ol.2020.11478
MLA
Nie, M., Pan, X., Tao, H., Xu, M., Liu, S., Sun, W., Wu, J., Zou, X."Clinical and prognostic significance of MYH11 in lung cancer". Oncology Letters 19.6 (2020): 3899-3906.
Chicago
Nie, M., Pan, X., Tao, H., Xu, M., Liu, S., Sun, W., Wu, J., Zou, X."Clinical and prognostic significance of MYH11 in lung cancer". Oncology Letters 19, no. 6 (2020): 3899-3906. https://doi.org/10.3892/ol.2020.11478
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