Open Access

Clinical and prognostic significance of MYH11 in lung cancer

  • Authors:
    • Meng‑Jun Nie
    • Xiao‑Ting Pan
    • He‑Yun Tao
    • Meng‑Jun Xu
    • Shen‑Lin Liu
    • Wei Sun
    • Jian Wu
    • Xi Zou
  • View Affiliations

  • Published online on: March 27, 2020     https://doi.org/10.3892/ol.2020.11478
  • Pages: 3899-3906
  • Copyright: © Nie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Myosin heavy chain 11 (MYH11), encoded by the MYH11 gene, is a protein that participates in muscle contraction through the hydrolysis of adenosine triphosphate. Although previous studies have demonstrated that MYH11 gene expression levels are downregulated in several types of cancer, its expression levels have rarely been investigated in lung cancer. The present study aimed to explore the clinical significance and prognostic value of MYH11 expression levels in lung cancer and to further study the underlying molecular mechanisms of the function of this gene. The Oncomine database showed that the MYH11 expression levels were decreased in lung cancer compared with those noted in the normal lung tissue (P<0.05). Kaplan‑Meier plotter results revealed that the decreased MYH11 expression levels were correlated with poor prognosis in lung cancer patients. Among the lung cancer cases with gene alteration of MYH11, mutation was the most common of all alteration types. Coexpedia and Metascape analyses revealed that the target genes were primarily enriched in ‘muscle contraction’, ‘contractile fiber part’, ‘actin cytoskeleton’ and the ‘adherens junction’. These results indicated that MYH11 is a potential novel drug target and prognostic indicator of lung cancer.
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June-2020
Volume 19 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Nie MJ, Pan XT, Tao HY, Xu MJ, Liu SL, Sun W, Wu J and Zou X: Clinical and prognostic significance of MYH11 in lung cancer. Oncol Lett 19: 3899-3906, 2020.
APA
Nie, M., Pan, X., Tao, H., Xu, M., Liu, S., Sun, W. ... Zou, X. (2020). Clinical and prognostic significance of MYH11 in lung cancer. Oncology Letters, 19, 3899-3906. https://doi.org/10.3892/ol.2020.11478
MLA
Nie, M., Pan, X., Tao, H., Xu, M., Liu, S., Sun, W., Wu, J., Zou, X."Clinical and prognostic significance of MYH11 in lung cancer". Oncology Letters 19.6 (2020): 3899-3906.
Chicago
Nie, M., Pan, X., Tao, H., Xu, M., Liu, S., Sun, W., Wu, J., Zou, X."Clinical and prognostic significance of MYH11 in lung cancer". Oncology Letters 19, no. 6 (2020): 3899-3906. https://doi.org/10.3892/ol.2020.11478