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Article

Validation and proposed modification of the 8th edition American Joint Committee on Cancer staging system for patients with esophageal neuroendocrine neoplasms: Evaluation of a revised lymph node classification

  • Authors:
    • Haihong Wang
    • Yaobing Chen
    • Guoliang Pi
    • Ying Zhu
    • Shengli Yang
    • Hong Mei
    • Zhenyu Lin
    • Tao Zhang
  • View Affiliations / Copyright

    Affiliations: Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China, Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China, Department of Radiation Oncology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430079, P.R. China, Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China
  • Pages: 4122-4132
    |
    Published online on: March 27, 2020
       https://doi.org/10.3892/ol.2020.11480
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Abstract

There is currently no universally accepted staging system for esophageal neuroendocrine neoplasms (ENENs). In the present study, patients with ENENs, identified from the Surveillance, Epidemiology, and End Results registry (SEER) (n=191 patients) and the multicentric series (n=51 patients), were stratified to assess the validity of the 8th American Joint Committee on Cancer (AJCC) staging systems, particularly for esophageal squamous cell carcinoma and esophageal adenocarcinoma. The Kaplan‑Meier method was used to assess disease‑specific survival (DSS), according to the Tumor‑Node‑Metastasis (TNM) status, and the Cox model was applied to evaluate differences in prognosis after adjustment for potential confounders. For the 8th AJCC staging classifications, only the pathological stage groups (pTNM) conferred increased hazard ratios from stage I to stage IV, with overlaps between adjacent stages. According to the current findings, the regional lymph nodes involvement status other than the current N classification was a significant predictor of DSS. Consequently, a revised N(Nr) classification was proposed and therefore a new TNrM staging system was adopted, for which progressively poorer DSS associated with increasing stage was observed. Moreover, the concordance index with the modified staging system was slightly higher in patients with ENENs from the SEER registry compared with that of the 8th pTNM system. In conclusion, lymph node status, rather than the number of positive lymph nodes, was a marker of poorer DSS and the modified staging system provided an easier and more accurate staging tool. The present results indicate that revisions to the current staging classifications may be improve the assessment of patient prognosis.
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1 

Modlin IM and Sandor A: An analysis of 8305 cases of carcinoid tumors. Cancer. 79:813–829. 1997. View Article : Google Scholar : PubMed/NCBI

2 

Gastrointestinal Pathology Study Group of Korean Society of Pathologists, ; Cho MY, Kim JM, Sohn JH, Kim MJ, Kim KM, Kim WH, Kim H, Kook MC, Park DY, et al: Current trends of the incidence and pathological diagnosis of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in Korea 2000–2009: Multicenter study. Cancer Res Treat. 44:157–165. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Lee CG, Lim YJ, Park SJ, Jang BI, Choi SR, Kim JK, Kim YT, Cho JY, Yang CH, Chun HJ, et al: The clinical features and treatment modality of esophageal neuroendocrine tumors: A multicenter study in Korea. BMC Cancer. 14:5692014. View Article : Google Scholar : PubMed/NCBI

4 

Wang KL, Yang Q, Cleary KR, Swisher SG, Correa AM, Komaki R, Ajani JA, Rashid A, Hamilton SR and Wu TT: The significance of neuroendocrine differentiation in adenocarcinoma of the esophagus and esophagogastric junction after preoperative chemoradiation. Cancer. 107:1467–1474. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Huang Q, Wu H, Nie L, Shi J, Lebenthal A, Chen J, Sun Q, Yang J, Huang L and Ye Q: Primary high-grade neuroendocrine carcinoma of the esophagus: A clinicopathologic and immunohistochemical study of 42 resection cases. Am J Surg Pathol. 37:467–483. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Deng HY, Ni PZ, Wang YC, Wang WP and Chen LQ: Neuroendocrine carcinoma of the esophagus: Clinical characteristics and prognostic evaluation of 49 cases with surgical resection. J Thorac Dis. 8:1250–1256. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Maru DM, Khurana H, Rashid A, Correa AM, Anandasabapathy S, Krishnan S, Komaki R, Ajani JA, Swisher SG and Hofstetter WL: Retrospective study of clinicopathologic features and prognosis of high-grade neuroendocrine carcinoma of the esophagus. Am J Surg Pathol. 32:1404–1411. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Deng HY, Li G, Luo J, Li XR, Alai G and Lin YD: The role of surgery in treating resectable limited disease of esophageal neuroendocrine carcinoma. World J Surg. 42:2428–2436. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Okuma HS, Iwasa S, Shoji H, Takashima A, Okita N, Honma Y, Kato K, Hamaguchi T, Yamada Y and Shimada Y: Irinotecan plus cisplatin in patients with extensive-disease poorly differentiated neuroendocrine carcinoma of the esophagus. Anticancer Res. 34:5037–5041. 2014.PubMed/NCBI

10 

Rice TW, Ishwaran H, Ferguson MK, Blackstone EH and Goldstraw P: Cancer of the esophagus and esophagogastric junction: An eighth edition staging primer. J Thorac Oncol. 12:36–42. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Rindi G, Falconi M, Klersy C, Albarello L, Boninsegna L, Buchler MW, Capella C, Caplin M, Couvelard A, Doglioni C, et al: TNM staging of neoplasms of the endocrine pancreas: Results from a large international cohort study. J Natl Cancer Inst. 104:764–777. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Rice TW, Ishwaran H, Hofstetter WL, Kelsen DP, Apperson-Hansen C and Blackstone EH; Worldwide Esophageal Cancer Collaboration Investigators, : Recommendations for pathologic staging (pTNM) of cancer of the esophagus and esophagogastric junction for the 8th edition AJCC/UICC staging manuals. Dis Esophagus. 29:897–905. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Rice TW, Ishwaran H, Kelsen DP, Hofstetter WL, Apperson-Hansen C and Blackstone EH; Worldwide Esophageal Cancer Collaboration Investigators, : Recommendations for neoadjuvant pathologic staging (ypTNM) of cancer of the esophagus and esophagogastric junction for the 8th edition AJCC/UICC staging manuals. Dis Esophagus. 29:906–912. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Rice TW, Ishwaran H, Blackstone EH, Hofstetter WL, Kelsen DP and Apperson-Hansen C; Worldwide Esophageal Cancer Collaboration Investigators, : Recommendations for clinical staging (cTNM) of cancer of the esophagus and esophagogastric junction for the 8th edition AJCC/UICC staging manuals. Dis Esophagus. 29:913–919. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Luo G, Javed A, Strosberg JR, Jin K, Zhang Y, Liu C, Xu J, Soares K, Weiss MJ, Zheng L, et al: Modified staging classification for pancreatic neuroendocrine tumors on the basis of the American joint committee on cancer and European neuroendocrine tumor society systems. J Clin Oncol. 35:274–280. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Kim MK, Warner RR, Roayaie S, Harpaz N, Ward SC, Itzkowitz S and Wisnivesky JP: Revised staging classification improves outcome prediction for small intestinal neuroendocrine tumors. J Clin Oncol. 31:3776–3781. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Martin JA, Warner RR, Wisnivesky JP and Kim MK: Improving survival prognostication of gastroenteropancreatic neuroendocrine neoplasms: Revised staging criteria. Eur J Cancer. 76:197–204. 2017. View Article : Google Scholar : PubMed/NCBI

18 

RStudio Team, . RStudio: Integrated Development for R. RStudio, Inc., Boston, MA, 2015. http://www.rstudio.com/

19 

R Core Team, . R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, 2012. http://www.R-project.org/

20 

Cuccurullo V and Mansi L: AJCC cancer staging handbook: From the AJCC cancer staging manual (7th edition). Eur J Nuclear Med Mol Imaging. 38:408. 2011. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Chen Y, Pi G, Zhu Y, Yang S, Mei H, Lin Z and Zhang T: Validation and proposed modification of the 8th edition American Joint Committee on Cancer staging system for patients with esophageal neuroendocrine neoplasms: Evaluation of a revised lymph node classification. Oncol Lett 19: 4122-4132, 2020.
APA
Wang, H., Chen, Y., Pi, G., Zhu, Y., Yang, S., Mei, H. ... Zhang, T. (2020). Validation and proposed modification of the 8th edition American Joint Committee on Cancer staging system for patients with esophageal neuroendocrine neoplasms: Evaluation of a revised lymph node classification. Oncology Letters, 19, 4122-4132. https://doi.org/10.3892/ol.2020.11480
MLA
Wang, H., Chen, Y., Pi, G., Zhu, Y., Yang, S., Mei, H., Lin, Z., Zhang, T."Validation and proposed modification of the 8th edition American Joint Committee on Cancer staging system for patients with esophageal neuroendocrine neoplasms: Evaluation of a revised lymph node classification". Oncology Letters 19.6 (2020): 4122-4132.
Chicago
Wang, H., Chen, Y., Pi, G., Zhu, Y., Yang, S., Mei, H., Lin, Z., Zhang, T."Validation and proposed modification of the 8th edition American Joint Committee on Cancer staging system for patients with esophageal neuroendocrine neoplasms: Evaluation of a revised lymph node classification". Oncology Letters 19, no. 6 (2020): 4122-4132. https://doi.org/10.3892/ol.2020.11480
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Chen Y, Pi G, Zhu Y, Yang S, Mei H, Lin Z and Zhang T: Validation and proposed modification of the 8th edition American Joint Committee on Cancer staging system for patients with esophageal neuroendocrine neoplasms: Evaluation of a revised lymph node classification. Oncol Lett 19: 4122-4132, 2020.
APA
Wang, H., Chen, Y., Pi, G., Zhu, Y., Yang, S., Mei, H. ... Zhang, T. (2020). Validation and proposed modification of the 8th edition American Joint Committee on Cancer staging system for patients with esophageal neuroendocrine neoplasms: Evaluation of a revised lymph node classification. Oncology Letters, 19, 4122-4132. https://doi.org/10.3892/ol.2020.11480
MLA
Wang, H., Chen, Y., Pi, G., Zhu, Y., Yang, S., Mei, H., Lin, Z., Zhang, T."Validation and proposed modification of the 8th edition American Joint Committee on Cancer staging system for patients with esophageal neuroendocrine neoplasms: Evaluation of a revised lymph node classification". Oncology Letters 19.6 (2020): 4122-4132.
Chicago
Wang, H., Chen, Y., Pi, G., Zhu, Y., Yang, S., Mei, H., Lin, Z., Zhang, T."Validation and proposed modification of the 8th edition American Joint Committee on Cancer staging system for patients with esophageal neuroendocrine neoplasms: Evaluation of a revised lymph node classification". Oncology Letters 19, no. 6 (2020): 4122-4132. https://doi.org/10.3892/ol.2020.11480
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