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Bioinformatics analyses and biological function of lncRNA ZFPM2‑AS1 and ZFPM2 gene in hepatocellular carcinoma

  • Authors:
    • Yi Luo
    • Xiaojun Wang
    • Ling Ma
    • Zhihua Ma
    • Shen Li
    • Xiaoyu Fang
    • Xiangyu Ma
  • View Affiliations / Copyright

    Affiliations: Department of Epidemiology, College of Preventive Medicine, Army Military Medical University, Chongqing 400038, P.R. China, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Army Military Medical University, Chongqing 400038, P.R. China, Department of Pediatrics, Banan People's Hospital of Chongqing, Chongqing 401320, P.R. China, Department of Anesthesia, The First Affiliated Hospital of Army Military Medical University, Chongqing 400038, P.R. China, The Second Clinical College, Chongqing Medical University, Chongqing 400010, P.R. China, College of Preventive Medicine, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China
    Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3677-3686
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    Published online on: March 27, 2020
       https://doi.org/10.3892/ol.2020.11485
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Abstract

Hepatocellular carcinoma (HCC) remains one of the most lethal malignant tumors worldwide; however, the etiology of HCC still remains poorly understood. In the present study, cancer‑omics databases, including The Cancer Genome Atlas, GTEx and Gene Expression Omnibus, were systematically analyzed in order to investigate the role of the long non‑coding RNA (lncRNA) zinc finger protein, FOG family member 2‑antisense 1 (ZFPM2‑AS1) and the zinc finger protein, FOG family member 2 (ZFPM2) gene in the occurrence and progression of HCC. It was identified that the expression levels of lncRNA ZFPM2‑AS1 were significantly increased in HCC tissues, whereas expression levels of the ZFPM2 gene were significantly decreased in HCC tissues compared with normal liver tissues. Higher expression levels of ZFPM2‑AS1 were significantly associated with a less favorable prognosis of HCC, whereas higher expression levels of the ZFPM2 gene were associated with a more favorable prognosis of HCC. Genetic alterations in the ZFPM2 gene may contribute to a worse prognosis of HCC. Validation of the GSE14520 dataset also demon stared that ZFPM2 gene expression levels were significantly decreased in HCC tissues (P<0.001). The receiver operating characteristic (ROC) analysis of the ZFPM2 gene indicated high accuracy of this gene in distinguishing between HCC tissues and non‑tumor tissues. The areas under the ROC curves were >0.8. Using integrated strategies, the present study demonstrated that lncRNA ZFPM2‑AS1 and the ZFPM2 gene may contribute to the occurrence and prognosis of HCC. These findings may provide a novel understanding of the molecular mechanisms underlying the occurrence and prognosis of HCC.
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Spandidos Publications style
Luo Y, Wang X, Ma L, Ma Z, Li S, Fang X and Ma X: Bioinformatics analyses and biological function of lncRNA ZFPM2‑AS1 and ZFPM2 gene in hepatocellular carcinoma. Oncol Lett 19: 3677-3686, 2020.
APA
Luo, Y., Wang, X., Ma, L., Ma, Z., Li, S., Fang, X., & Ma, X. (2020). Bioinformatics analyses and biological function of lncRNA ZFPM2‑AS1 and ZFPM2 gene in hepatocellular carcinoma. Oncology Letters, 19, 3677-3686. https://doi.org/10.3892/ol.2020.11485
MLA
Luo, Y., Wang, X., Ma, L., Ma, Z., Li, S., Fang, X., Ma, X."Bioinformatics analyses and biological function of lncRNA ZFPM2‑AS1 and ZFPM2 gene in hepatocellular carcinoma". Oncology Letters 19.6 (2020): 3677-3686.
Chicago
Luo, Y., Wang, X., Ma, L., Ma, Z., Li, S., Fang, X., Ma, X."Bioinformatics analyses and biological function of lncRNA ZFPM2‑AS1 and ZFPM2 gene in hepatocellular carcinoma". Oncology Letters 19, no. 6 (2020): 3677-3686. https://doi.org/10.3892/ol.2020.11485
Copy and paste a formatted citation
x
Spandidos Publications style
Luo Y, Wang X, Ma L, Ma Z, Li S, Fang X and Ma X: Bioinformatics analyses and biological function of lncRNA ZFPM2‑AS1 and ZFPM2 gene in hepatocellular carcinoma. Oncol Lett 19: 3677-3686, 2020.
APA
Luo, Y., Wang, X., Ma, L., Ma, Z., Li, S., Fang, X., & Ma, X. (2020). Bioinformatics analyses and biological function of lncRNA ZFPM2‑AS1 and ZFPM2 gene in hepatocellular carcinoma. Oncology Letters, 19, 3677-3686. https://doi.org/10.3892/ol.2020.11485
MLA
Luo, Y., Wang, X., Ma, L., Ma, Z., Li, S., Fang, X., Ma, X."Bioinformatics analyses and biological function of lncRNA ZFPM2‑AS1 and ZFPM2 gene in hepatocellular carcinoma". Oncology Letters 19.6 (2020): 3677-3686.
Chicago
Luo, Y., Wang, X., Ma, L., Ma, Z., Li, S., Fang, X., Ma, X."Bioinformatics analyses and biological function of lncRNA ZFPM2‑AS1 and ZFPM2 gene in hepatocellular carcinoma". Oncology Letters 19, no. 6 (2020): 3677-3686. https://doi.org/10.3892/ol.2020.11485
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