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Identification of differentially expressed genes and biological pathways in para‑carcinoma tissues of HCC with different metastatic potentials

  • Authors:
    • Yan Liu
    • Mingming Deng
    • Yimeng Wang
    • Huiqin Wang
    • Changping Li
    • Hao Wu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The Chengdu Fifth People's Hospital, Chengdu, Sichuan 611130, P.R. China, Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China, Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3799-3814
    |
    Published online on: March 29, 2020
       https://doi.org/10.3892/ol.2020.11493
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Abstract

Hepatocellular carcinoma (HCC) is a malignant tumor with extensive metastasis. Changes in the tumor microenvironment provide favorable conditions for tumor metastasis. However, the role of changes to the tumor microenvironment in HCC metastasis is yet to be elucidated. The Gene Expression Omnibus expression profile GSE5093 consists of 20 noncancerous tissues surrounding HCC tissues, including 9 metastasis‑inclined microenvironment samples with detectable metastases and 11 metastasis‑averse microenvironment samples without detectable metastases. The present study assessed 35 HCC samples to verify the results of chip analysis. In total, 712 upregulated and 459 downregulated genes were identified, with 1,033 nodes, 7,589 edges and 10 hub genes. Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis revealed that the differentially expressed genes were significantly enriched in ‘cell‑cell adhesion’, ‘cell proliferation’ and ‘protein binding’. The top 10 hub genes were identified via a protein‑protein interaction analysis. The 3 most significant modules were identified from the protein‑protein network. Moreover, an association between hub genes and patient prognosis was identified. In conclusion, these candidate genes and pathways may help elucidate the mechanisms underlying HCC metastasis and identify more options for targeted therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Deng M, Wang Y, Wang H, Li C and Wu H: Identification of differentially expressed genes and biological pathways in para‑carcinoma tissues of HCC with different metastatic potentials. Oncol Lett 19: 3799-3814, 2020.
APA
Liu, Y., Deng, M., Wang, Y., Wang, H., Li, C., & Wu, H. (2020). Identification of differentially expressed genes and biological pathways in para‑carcinoma tissues of HCC with different metastatic potentials. Oncology Letters, 19, 3799-3814. https://doi.org/10.3892/ol.2020.11493
MLA
Liu, Y., Deng, M., Wang, Y., Wang, H., Li, C., Wu, H."Identification of differentially expressed genes and biological pathways in para‑carcinoma tissues of HCC with different metastatic potentials". Oncology Letters 19.6 (2020): 3799-3814.
Chicago
Liu, Y., Deng, M., Wang, Y., Wang, H., Li, C., Wu, H."Identification of differentially expressed genes and biological pathways in para‑carcinoma tissues of HCC with different metastatic potentials". Oncology Letters 19, no. 6 (2020): 3799-3814. https://doi.org/10.3892/ol.2020.11493
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Deng M, Wang Y, Wang H, Li C and Wu H: Identification of differentially expressed genes and biological pathways in para‑carcinoma tissues of HCC with different metastatic potentials. Oncol Lett 19: 3799-3814, 2020.
APA
Liu, Y., Deng, M., Wang, Y., Wang, H., Li, C., & Wu, H. (2020). Identification of differentially expressed genes and biological pathways in para‑carcinoma tissues of HCC with different metastatic potentials. Oncology Letters, 19, 3799-3814. https://doi.org/10.3892/ol.2020.11493
MLA
Liu, Y., Deng, M., Wang, Y., Wang, H., Li, C., Wu, H."Identification of differentially expressed genes and biological pathways in para‑carcinoma tissues of HCC with different metastatic potentials". Oncology Letters 19.6 (2020): 3799-3814.
Chicago
Liu, Y., Deng, M., Wang, Y., Wang, H., Li, C., Wu, H."Identification of differentially expressed genes and biological pathways in para‑carcinoma tissues of HCC with different metastatic potentials". Oncology Letters 19, no. 6 (2020): 3799-3814. https://doi.org/10.3892/ol.2020.11493
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