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Survivin expression as an independent predictor of overall survival in malignant peritoneal mesothelioma

  • Authors:
    • Guozun Zhang
    • Dong‑Liang Yang
    • Guoqi Zheng
    • Yufei Liang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, P.R. China, Department of Medical Statistics, Cangzhou Medical College, Cangzhou, Hebei 061001, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3871-3880
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    Published online on: April 2, 2020
       https://doi.org/10.3892/ol.2020.11505
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Abstract

Malignant peritoneal mesothelioma (MPeM) is an incurable cancer strongly associated with asbestos exposure and characterised by poor prognosis. The aim of the present study was to elucidate the prognostic and predictive value of CD146 and survivin expression in MPeM. Diagnostic biopsies from 60 patients with MPeM were collected and analysed for CD146, survivin and Ki‑67 expression using immunohistochemistry. Complete clinical and follow‑up information was obtained from patients' records. CD146 was expressed in 31/60 MPeM specimens and survivin in 34/60 specimens, with both expression levels being significantly associated with the Ki‑67 labelling index (Ki‑67LI). Kaplan‑Meier and univariate Cox regression analyses revealed that a lower peritoneal cancer index (PCI), tumour‑directed treatment, stage I, lower Ki‑67LI and lower CD146 and survivin expression had a statistically positive effect on overall survival (OS). Cox regression analysis revealed that PCI [hazard ratio (HR)=1.99; 95% CI, 1.04‑3.83; P=0.038], survivin (HR=1.47; 95% CI, 1.03‑2.10; P=0.034) and treatment protocol including intraperitoneal chemotherapy (HR=0.28; 95% CI, 0.14‑0.57; P=0.013) and systemic chemotherapy (HR=0.13; 95% CI, 0.04‑0.42; P=0.013) retained independent prognostic significance for OS. All of these were included in the nomogram. Calibration curves showed good agreement between nomogram‑predicted and observed survival. The C‑index of the nomogram for predicting OS was 0.77. A lower PCI, intraperitoneal chemotherapy, systemic chemotherapy and a lower level of survivin were powerful prognostic markers in patients with MPeM. The proposed nomogram provides individual survival prediction for patients with MPeM.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang G, Yang DL, Zheng G and Liang Y: Survivin expression as an independent predictor of overall survival in malignant peritoneal mesothelioma. Oncol Lett 19: 3871-3880, 2020.
APA
Zhang, G., Yang, D., Zheng, G., & Liang, Y. (2020). Survivin expression as an independent predictor of overall survival in malignant peritoneal mesothelioma. Oncology Letters, 19, 3871-3880. https://doi.org/10.3892/ol.2020.11505
MLA
Zhang, G., Yang, D., Zheng, G., Liang, Y."Survivin expression as an independent predictor of overall survival in malignant peritoneal mesothelioma". Oncology Letters 19.6 (2020): 3871-3880.
Chicago
Zhang, G., Yang, D., Zheng, G., Liang, Y."Survivin expression as an independent predictor of overall survival in malignant peritoneal mesothelioma". Oncology Letters 19, no. 6 (2020): 3871-3880. https://doi.org/10.3892/ol.2020.11505
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang G, Yang DL, Zheng G and Liang Y: Survivin expression as an independent predictor of overall survival in malignant peritoneal mesothelioma. Oncol Lett 19: 3871-3880, 2020.
APA
Zhang, G., Yang, D., Zheng, G., & Liang, Y. (2020). Survivin expression as an independent predictor of overall survival in malignant peritoneal mesothelioma. Oncology Letters, 19, 3871-3880. https://doi.org/10.3892/ol.2020.11505
MLA
Zhang, G., Yang, D., Zheng, G., Liang, Y."Survivin expression as an independent predictor of overall survival in malignant peritoneal mesothelioma". Oncology Letters 19.6 (2020): 3871-3880.
Chicago
Zhang, G., Yang, D., Zheng, G., Liang, Y."Survivin expression as an independent predictor of overall survival in malignant peritoneal mesothelioma". Oncology Letters 19, no. 6 (2020): 3871-3880. https://doi.org/10.3892/ol.2020.11505
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