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Article Open Access

Decreased biochemical progression in patients with castration‑resistant prostate cancer using a novel mefenamic acid anti‑inflammatory therapy: A randomized controlled trial

  • Authors:
    • José Guzman‑Esquivel
    • Martha A. Mendoza‑Hernandez
    • Daniel Tiburcio‑Jimenez
    • Oscar N. Avila‑Zamora
    • Josuel Delgado‑Enciso
    • Luis De‑Leon‑Zaragoza
    • Juan C. Casarez‑Price
    • Iram P. Rodriguez‑Sanchez
    • Margarita L. Martinez‑Fierro
    • Carmen Meza‑Robles
    • Alejandro Barocio‑Acosta
    • Luz M. Baltazar‑Rodriguez
    • Sergio A. Zaizar‑Fregoso
    • Jorge E. Plata‑Florenzano
    • Iván Delgado‑Enciso
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Medicine, School of Medicine, University of Colima, Colima 28040, Mexico, Department of Research, Cancerology State Institute, Colima State Health Services, Colima 28085, Mexico, Department of Research, Foundation for Cancer Ethics, Education and Research of The Cancerology State Institute, Colima 28085, Mexico, Department of Research, General Hospital of Zone No. 1 IMSS, Villa de Alvarez, Colima 28983, Mexico, Molecular and Structural Physiology Laboratory, School of Biological Sciences, Autonomous University of Nuevo León, Monterrey, Nuevo León 64460, Mexico, Molecular Medicine Laboratory, Academic Unit of Human Medicine and Health Sciences, Autonomous University of Zacatecas, Zacatecas, Zacatecas 98160, Mexico
    Copyright: © Guzman‑Esquivel et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4151-4160
    |
    Published online on: April 3, 2020
       https://doi.org/10.3892/ol.2020.11509
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Abstract

Prostate cancer (PCa) is the second most common non‑dermatological cancer in men and is a growing public health problem. Castration‑resistant disease (CRD) is the most advanced stage of the disease and is difficult to control. Patients with CRD may no longer accept conventional therapies as they are not in appropriate clinical conditions or they refuse to receive it. Given that inflammation is an essential component of CRD origin and progression, anti‑inflammatory agents could be a therapeutic option with fenamates as one of the proposed choices. A prospective, randomized, double‑blinded, 2‑arm, parallel group, phase II‑III clinical trial was performed involving 20 patients with CRD‑PCa (with a prostate specific antigen level <100 ng/ml) that were undergoing androgen deprivation therapy (ADT) and did not accept any established treatment for that disease stage. In addition to ADT, 10 patients received placebo and 10 received mefenamic acid (500 mg orally every 12 h) for 6 months. The primary endpoint was the change in serum prostate‑specific antigen (PSA) at 6 months. The PSA levels decreased significantly with mefenamic acid (an average 42% decrease), whereas there was an average 55% increase in the placebo group (P=0.024). In the patients treated with the placebo, 70% had biochemical disease progression (an increase of ≥25% in PSA levels), which did not occur in any of the patients treated with mefenamic acid (relative risk=0.12; 95% confidence interval, 0.01‑0.85; P=0.033). There was a significant increase in quality of life (EQ‑5D‑5L score) and body mass index (BMI) with the experimental treatment. In conclusion, mefenamic acid administration decreased biochemical progression in patients with castration resistant PCa, improved their quality of life and increased their BMI. Future studies are required in order to strengthen the findings of the present clinical trial. Trial registration, Cuban Public Registry of Clinical Trials Database RPCEC00000248, August 2017.
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Copy and paste a formatted citation
Spandidos Publications style
Guzman‑Esquivel J, Mendoza‑Hernandez MA, Tiburcio‑Jimenez D, Avila‑Zamora ON, Delgado‑Enciso J, De‑Leon‑Zaragoza L, Casarez‑Price JC, Rodriguez‑Sanchez IP, Martinez‑Fierro ML, Meza‑Robles C, Meza‑Robles C, et al: Decreased biochemical progression in patients with castration‑resistant prostate cancer using a novel mefenamic acid anti‑inflammatory therapy: A randomized controlled trial. Oncol Lett 19: 4151-4160, 2020.
APA
Guzman‑Esquivel, J., Mendoza‑Hernandez, M.A., Tiburcio‑Jimenez, D., Avila‑Zamora, O.N., Delgado‑Enciso, J., De‑Leon‑Zaragoza, L. ... Delgado‑Enciso, I. (2020). Decreased biochemical progression in patients with castration‑resistant prostate cancer using a novel mefenamic acid anti‑inflammatory therapy: A randomized controlled trial. Oncology Letters, 19, 4151-4160. https://doi.org/10.3892/ol.2020.11509
MLA
Guzman‑Esquivel, J., Mendoza‑Hernandez, M. A., Tiburcio‑Jimenez, D., Avila‑Zamora, O. N., Delgado‑Enciso, J., De‑Leon‑Zaragoza, L., Casarez‑Price, J. C., Rodriguez‑Sanchez, I. P., Martinez‑Fierro, M. L., Meza‑Robles, C., Barocio‑Acosta, A., Baltazar‑Rodriguez, L. M., Zaizar‑Fregoso, S. A., Plata‑Florenzano, J. E., Delgado‑Enciso, I."Decreased biochemical progression in patients with castration‑resistant prostate cancer using a novel mefenamic acid anti‑inflammatory therapy: A randomized controlled trial". Oncology Letters 19.6 (2020): 4151-4160.
Chicago
Guzman‑Esquivel, J., Mendoza‑Hernandez, M. A., Tiburcio‑Jimenez, D., Avila‑Zamora, O. N., Delgado‑Enciso, J., De‑Leon‑Zaragoza, L., Casarez‑Price, J. C., Rodriguez‑Sanchez, I. P., Martinez‑Fierro, M. L., Meza‑Robles, C., Barocio‑Acosta, A., Baltazar‑Rodriguez, L. M., Zaizar‑Fregoso, S. A., Plata‑Florenzano, J. E., Delgado‑Enciso, I."Decreased biochemical progression in patients with castration‑resistant prostate cancer using a novel mefenamic acid anti‑inflammatory therapy: A randomized controlled trial". Oncology Letters 19, no. 6 (2020): 4151-4160. https://doi.org/10.3892/ol.2020.11509
Copy and paste a formatted citation
x
Spandidos Publications style
Guzman‑Esquivel J, Mendoza‑Hernandez MA, Tiburcio‑Jimenez D, Avila‑Zamora ON, Delgado‑Enciso J, De‑Leon‑Zaragoza L, Casarez‑Price JC, Rodriguez‑Sanchez IP, Martinez‑Fierro ML, Meza‑Robles C, Meza‑Robles C, et al: Decreased biochemical progression in patients with castration‑resistant prostate cancer using a novel mefenamic acid anti‑inflammatory therapy: A randomized controlled trial. Oncol Lett 19: 4151-4160, 2020.
APA
Guzman‑Esquivel, J., Mendoza‑Hernandez, M.A., Tiburcio‑Jimenez, D., Avila‑Zamora, O.N., Delgado‑Enciso, J., De‑Leon‑Zaragoza, L. ... Delgado‑Enciso, I. (2020). Decreased biochemical progression in patients with castration‑resistant prostate cancer using a novel mefenamic acid anti‑inflammatory therapy: A randomized controlled trial. Oncology Letters, 19, 4151-4160. https://doi.org/10.3892/ol.2020.11509
MLA
Guzman‑Esquivel, J., Mendoza‑Hernandez, M. A., Tiburcio‑Jimenez, D., Avila‑Zamora, O. N., Delgado‑Enciso, J., De‑Leon‑Zaragoza, L., Casarez‑Price, J. C., Rodriguez‑Sanchez, I. P., Martinez‑Fierro, M. L., Meza‑Robles, C., Barocio‑Acosta, A., Baltazar‑Rodriguez, L. M., Zaizar‑Fregoso, S. A., Plata‑Florenzano, J. E., Delgado‑Enciso, I."Decreased biochemical progression in patients with castration‑resistant prostate cancer using a novel mefenamic acid anti‑inflammatory therapy: A randomized controlled trial". Oncology Letters 19.6 (2020): 4151-4160.
Chicago
Guzman‑Esquivel, J., Mendoza‑Hernandez, M. A., Tiburcio‑Jimenez, D., Avila‑Zamora, O. N., Delgado‑Enciso, J., De‑Leon‑Zaragoza, L., Casarez‑Price, J. C., Rodriguez‑Sanchez, I. P., Martinez‑Fierro, M. L., Meza‑Robles, C., Barocio‑Acosta, A., Baltazar‑Rodriguez, L. M., Zaizar‑Fregoso, S. A., Plata‑Florenzano, J. E., Delgado‑Enciso, I."Decreased biochemical progression in patients with castration‑resistant prostate cancer using a novel mefenamic acid anti‑inflammatory therapy: A randomized controlled trial". Oncology Letters 19, no. 6 (2020): 4151-4160. https://doi.org/10.3892/ol.2020.11509
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