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Article Open Access

Effects of high‑intensity focused ultrasound treatment on peripancreatic arterial and venous blood vessels in pancreatic cancer

  • Authors:
    • Xiaoyin Guo
    • Hui Zhu
    • Kun Zhou
    • Chengbing Jin
    • Yang Yang
    • Jun Zhang
    • Wei Yang
    • Lifeng Ran
    • Dobromir Dimitrov Dimitrov
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Ultrasound Engineering in Medicine Co‑Founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, P.R. China, Clinical Center for Tumor Therapy, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China, Department of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China, Department of Surgery, Medical University Pleven, Pleven 5800, Bulgaria
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3839-3850
    |
    Published online on: April 3, 2020
       https://doi.org/10.3892/ol.2020.11511
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Abstract

The present study aimed to evaluate the safety of high‑intensity focused ultrasound (HIFU) treatment on peripancreatic arterial and venous blood vessels in patients with pancreatic cancer. This trial included 15 patients with pancreatic cancer (9 females and 6 males; age, 39‑81 years; median age, 62 years). All patients underwent preoperative computed tomography (CT) or magnetic resonance imaging (MRI) and color Doppler flow imaging (CDFI) to assess the vascular hemodynamics of peripancreatic arterial and venous blood vessels pre‑treatment. These patients were re‑examined within 1 week post‑HIFU treatment. Then, vascular adverse events were observed and followed up clinically. Prior to HIFU treatment, vessel involvement was recorded in 13 patients, including tumor lesions invading 19 veins and 14 arteries, which refers to the growth of pancreatic tumor lesions surrounding blood vessels, or tumor growth into blood vessels. In addition, 9 veins and 13 arteries were <1 cm from the lesions. The hemodynamic parameters of peripancreatic vessels were measured using CDFI, including mean blood flow velocity, peak systolic blood flow velocity, vascular resistance index, vascular pulsatility index, vascular diameter, vascular blood flow and other indicators, to assess vascular perfusion in CT/MRI. There were no significant differences in preoperative and postoperative hemodynamic data (P>0.05). Overall, HIFU demonstrated no negative effects on peripancreatic arterial and venous blood vessels in patients with pancreatic cancer, even with tumor lesions wrapped in blood vessels. In addition, no complications of vascular stenosis and vascular adverse events were observed in the present study.
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Copy and paste a formatted citation
Spandidos Publications style
Guo X, Zhu H, Zhou K, Jin C, Yang Y, Zhang J, Yang W, Ran L and Dimitrov DD: Effects of high‑intensity focused ultrasound treatment on peripancreatic arterial and venous blood vessels in pancreatic cancer . Oncol Lett 19: 3839-3850, 2020.
APA
Guo, X., Zhu, H., Zhou, K., Jin, C., Yang, Y., Zhang, J. ... Dimitrov, D.D. (2020). Effects of high‑intensity focused ultrasound treatment on peripancreatic arterial and venous blood vessels in pancreatic cancer . Oncology Letters, 19, 3839-3850. https://doi.org/10.3892/ol.2020.11511
MLA
Guo, X., Zhu, H., Zhou, K., Jin, C., Yang, Y., Zhang, J., Yang, W., Ran, L., Dimitrov, D. D."Effects of high‑intensity focused ultrasound treatment on peripancreatic arterial and venous blood vessels in pancreatic cancer ". Oncology Letters 19.6 (2020): 3839-3850.
Chicago
Guo, X., Zhu, H., Zhou, K., Jin, C., Yang, Y., Zhang, J., Yang, W., Ran, L., Dimitrov, D. D."Effects of high‑intensity focused ultrasound treatment on peripancreatic arterial and venous blood vessels in pancreatic cancer ". Oncology Letters 19, no. 6 (2020): 3839-3850. https://doi.org/10.3892/ol.2020.11511
Copy and paste a formatted citation
x
Spandidos Publications style
Guo X, Zhu H, Zhou K, Jin C, Yang Y, Zhang J, Yang W, Ran L and Dimitrov DD: Effects of high‑intensity focused ultrasound treatment on peripancreatic arterial and venous blood vessels in pancreatic cancer . Oncol Lett 19: 3839-3850, 2020.
APA
Guo, X., Zhu, H., Zhou, K., Jin, C., Yang, Y., Zhang, J. ... Dimitrov, D.D. (2020). Effects of high‑intensity focused ultrasound treatment on peripancreatic arterial and venous blood vessels in pancreatic cancer . Oncology Letters, 19, 3839-3850. https://doi.org/10.3892/ol.2020.11511
MLA
Guo, X., Zhu, H., Zhou, K., Jin, C., Yang, Y., Zhang, J., Yang, W., Ran, L., Dimitrov, D. D."Effects of high‑intensity focused ultrasound treatment on peripancreatic arterial and venous blood vessels in pancreatic cancer ". Oncology Letters 19.6 (2020): 3839-3850.
Chicago
Guo, X., Zhu, H., Zhou, K., Jin, C., Yang, Y., Zhang, J., Yang, W., Ran, L., Dimitrov, D. D."Effects of high‑intensity focused ultrasound treatment on peripancreatic arterial and venous blood vessels in pancreatic cancer ". Oncology Letters 19, no. 6 (2020): 3839-3850. https://doi.org/10.3892/ol.2020.11511
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