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Article Open Access

Translation regulatory long non‑coding RNA 1 represents a potential prognostic biomarker for colorectal cancer

  • Authors:
    • Weijia Wang
    • Xiaolong Tang
    • Hui Qu
    • Qingsi He
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4077-4087
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    Published online on: April 10, 2020
       https://doi.org/10.3892/ol.2020.11532
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Abstract

Long non‑coding RNAs (lncRNAs) have attracted a lot of attention for their role in the development, progression and prognosis of colorectal cancer (CRC). However, little is known on the clinical significance of the translation regulatory lncRNA 1 (TRERNA1) in CRC. The present study aimed to explore the clinical value of TRERNA1 in patients with CRC. A total of 89 cancer‑associated lncRNA genes were analyzed using the RT² lncRNA PCR array Human Cancer PathwayFinder. Following the PCR array, reverse transcription‑quantitative (RT‑q)PCR was conducted to identify the differential expression of TRERNA1 between 130 CRC and corresponding non‑tumorous adjacent tissues. Additionally, the association between TRERNA1 expression and clinical characteristics was analyzed. Furthermore, TRERNA1 expression was knocked down via small interfering RNAs. The results of the PCR array and RT‑qPCR revealed that TRERNA1 expression was significantly upregulated in CRC tissues compared with in adjacent normal tissues. TRERNA1 upregulation was positively associated with distant metastasis, perineural invasion, TNM stage, node metastasis stage and tumor diameter. Multivariate analysis revealed that patients with higher TRERNA1 expression had a shorter overall survival (OS) time and a less favorable prognosis compared with those in the low TRERNA1 expression group. Knockdown of TRERNA1 inhibited invasion and metastasis of CRC cells via regulating Snail expression. In conclusion, TRERNA1 expression was upregulated in CRC tissues. High expression levels of TRERNA1 may be associated with poor OS times, a less favorable prognosis and lymph node metastasis in patients with CRC. TRERNA1 may therefore serve as a useful and novel biomarker for CRC lymph node metastasis and prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Wang W, Tang X, Qu H and He Q: Translation regulatory long non‑coding RNA 1 represents a potential prognostic biomarker for colorectal cancer. Oncol Lett 19: 4077-4087, 2020.
APA
Wang, W., Tang, X., Qu, H., & He, Q. (2020). Translation regulatory long non‑coding RNA 1 represents a potential prognostic biomarker for colorectal cancer. Oncology Letters, 19, 4077-4087. https://doi.org/10.3892/ol.2020.11532
MLA
Wang, W., Tang, X., Qu, H., He, Q."Translation regulatory long non‑coding RNA 1 represents a potential prognostic biomarker for colorectal cancer". Oncology Letters 19.6 (2020): 4077-4087.
Chicago
Wang, W., Tang, X., Qu, H., He, Q."Translation regulatory long non‑coding RNA 1 represents a potential prognostic biomarker for colorectal cancer". Oncology Letters 19, no. 6 (2020): 4077-4087. https://doi.org/10.3892/ol.2020.11532
Copy and paste a formatted citation
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Spandidos Publications style
Wang W, Tang X, Qu H and He Q: Translation regulatory long non‑coding RNA 1 represents a potential prognostic biomarker for colorectal cancer. Oncol Lett 19: 4077-4087, 2020.
APA
Wang, W., Tang, X., Qu, H., & He, Q. (2020). Translation regulatory long non‑coding RNA 1 represents a potential prognostic biomarker for colorectal cancer. Oncology Letters, 19, 4077-4087. https://doi.org/10.3892/ol.2020.11532
MLA
Wang, W., Tang, X., Qu, H., He, Q."Translation regulatory long non‑coding RNA 1 represents a potential prognostic biomarker for colorectal cancer". Oncology Letters 19.6 (2020): 4077-4087.
Chicago
Wang, W., Tang, X., Qu, H., He, Q."Translation regulatory long non‑coding RNA 1 represents a potential prognostic biomarker for colorectal cancer". Oncology Letters 19, no. 6 (2020): 4077-4087. https://doi.org/10.3892/ol.2020.11532
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